The research area division Drug Discovery is divided into the departments Drug Discovery and High Resolution and Automated Microscopy at the Göttingen site. The Drug Discovery department at the Frankfurt am Main and Hamburg sites comprises several working groups.
Drug Discovery - Frankfurt am Main and Hamburg
Discovery Research – ScreeningPort
(Head: Dr. Philip Gribbon, Hamburg)
The expertise of the working group lies in high-throughput biology, such as the development of automated biological test systems and high-throughput screening for new pharmacologically active substances, also using automated imaging techniques. Other areas of focus include the repositioning of known compounds for new indications and the development and application of innovative stem cell technologies for testing the efficacy and safety of drug candidates.
(Head: Prof. Dr. Dieter Steinhilber, Frankfurt am Main)
The group focuses on chemical synthesis, structural optimization and pharmacological characterization of lead compounds at the molecular and cellular level, in combination with in silico methods for the identification and design of new drugs (ligand and target protein-based virtual screening, quantitative structure-activity models).
(Head: Prof. Dr. Jennifer Dressman, Frankfurt am Main)
The research group focuses on the development and application of innovative methods for drug formulation and release. Special emphasis is placed on the preformulation and classification of drug candidates with respect to their development potential (refined Development Classification System, rDCS), the development of peroral and parenteral formulations, biorelevant release methods and physiologically-based pharmacokinetic models.
Biomedical Data Science
(Head: Prof. Dr. Carsten Claussen, Gesa Witt, Hamburg)
The working group is concerned with the analysis of large data sets, the integration of data from different types of experiments and studies, and the preparation, processing and storage of data according to the FAIR principles (findable, accessible, interoperable, reusable). In addition, drug discovery programs are supported using chemo- and bioinformatics methods and binding simulations.
High-resolution and automated microscopy – Göttingen
(Head: Prof. Dr. Stefan Jakobs, Göttingen)
The research group uses high- and super-resolution microscopy techniques to visualize sub-cellular structures on the nanoscale. The automation of these techniques and innovative image analysis algorithms allow the investigation of the influence of pharmacologically active substances on the nanostructure of (living) cells with high throughput.