Talk on the topic of "Assays and workflows for molecular degrader discovery"
April 2026
"Targeted Protein Degradation: Drugging the Undruggable" was the title of the Paul Martini Foundation's workshop. In April 2026, numerous renowned scientists gathered at the Berlin-Brandenburg Academy of Sciences to present on this important topic. Dr. Johanna Huchting from the Hamburg site of the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP was also on site and provided insights into her current research in frame of Cluster4Future PROXIDRUGS.
In her talk "Assays and workflows for molecular degrader discovery", she discussed AI-supported drug screening for Targeted Protein Degradation. For Targeted Protein Degradation (TPD), automated high-throughput assays (e.g., FRET), high-content imaging, and cell painting are used to reliably test degradation mechanisms. In addition, iPSC models of the blood-brain barrier and AI-supported data analyses help to make translation into the clinic – for example, in neurodegenerative diseases – safer and more efficient.
The video is now available on the Paul Martini Foundation's website and is accessible to all interested parties. The link below leads directly to the talk: Workshop der Paul-Martini-Stiftung 2026
More information about Fraunhofer ITMP, Hamburg site:
Projects - Fraunhofer ITMP
Drug Screening & Compound Repurposing - Fraunhofer ITMP
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP