Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
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4D Inflammation Clinic

Chronic immune-mediated inflammatory diseases (IMIDs) are characterized by high clinical heterogeneity and multi-organ involvement, which can significantly complicate early diagnosis. This is where the 4D Inflammation Clinic comes in: it brings together expertise from rheumatology, dermatology, and gastroenterology to assess symptoms in a holistic and interdisciplinary manner. At the same time, we connect clinical expertise with innovative research. Our approach breaks away from the traditional organ-centric view and aims to understand cross-disease mechanisms. Using modern technologies and data-driven analyses, we identify new biomarkers and develop more precise diagnostic and prognostic models. This creates the foundation for earlier diagnoses and individualized therapies—with the goal of sustainably improving disease courses and preserving quality of life.

 

Core Expertise:

  • Clinical-scientific integration: Deep expertise in inflammatory medicine combined with modern data-driven analysis approaches
  • Unique cohorts: Access to comprehensively characterized patient cohorts as a basis for translational research
  • 4D approach: Interdisciplinary strategies across Data, Diagnostics, Drugs, and Devices to improve diagnosis and therapy
  • Participation: Active inclusion of patient perspectives through the multidisciplinary IMPACT Advisory Board
  • Study competence: Planning and conducting clinical and scientific studies in inflammatory medicine

 

Objectives/Services:

  • Interdisciplinary care: Joint rheumatology, dermatology, and gastroenterology clinic for faster, coordinated diagnosis and treatment of IMIDs
  • Innovative research: Development of diagnostic and prognostic biomarker profiles using longitudinal multi-omics analysis
  • Data-driven medicine: Creation of modern tools for collecting, analyzing, and integrating complex clinical and molecular data
  • Strong network: Close connections to top university centers, such as Charité – Universitätsmedizin Berlin and Universitätsmedizin Frankfurt
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CIMD Real-World Laboratory 4D Clinic

The Real Lab 4D Clinic is developing a digital research and care platform for IMIDs. Clinical data, omics analyses, and AI-based evaluations are integrated to better understand disease mechanisms, support treatment decisions, and enable personalized treatment strategies.

Weiterführende Informationen

PsA-vINGEST

PsA-vINGEST investigates sex-specific differences in the diagnosis and treatment of psoriatic arthritis. The aim is to develop interactive digital technologies that support sex- and gender-sensitive analyses and treatment recommendations, thereby strengthening precision medicine in rheumatology.

Weiterführende Informationen

IMMUVision

ImmUVision is developing a digital platform for the care of patients with complex immune and inflammatory diseases. Using digital twin technology, individual health data are integrated with clinical guidelines and population-based knowledge to improve diagnostics, treatment decisions, and cross-sector care.

Weiterführende Informationen

Gurke R, Bendes A, Bowes J, Koehm M, Twyman RM, Barton A, Elewaut D, Goodyear C, Hahnefeld L, Hillenbrand R, Hunter E, Ibberson M, Ioannidis V, Kugler S, Lories RJ, Resch E, Rüping S, Scholich K, Schwenk JM, Waddington JC, Whitfield P, Geisslinger G, FitzGerald O, Behrens F, Pennington SR; HIPPOCRATES Consortium; Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis.
Biomedicines 2022 Sep 24;10(10):2387
doi: 10.3390/biomedicines10102387

 

Koehm M, Behrens F; Association between biological immunotherapy for psoriasis and time to incident inflammatory arthritis: limitations and opportunities. 
RMD Open. 2023 Sep;9(3):e003166
doi: 10.1136/rmdopen-2023-003166

 

Witte T, Minopoulou I, Drzeniek NM, Torgutalp M, Sabat R, Casteleyn V, Albach F, Fagni F, Schett G, Zabotti A, Krönke G, McGonagle D, Köhm M, Behrens F, Kleyer A, Simon D. Advances in precision medicine in imaging and therapeutic strategies for psoriatic disease.
Autoimmun Rev. 2025 Jul 31;24(8):103839.
doi: 10.1016/j.autrev.2025.103839.

 

Minopoulou I, Kleyer A, Yalcin-Mutlu M, Fagni F, Kemenes S, Schmidkonz C, Atzinger A, Pachowsky M, Engel K, Folle L, Roemer F, Waldner M, D'Agostino MA, Schett G, Simon D. Imaging in inflammatory arthritis: progress towards precision medicine.
Nat Rev Rheumatol. 2023 Oct;19(10):650-665.
doi: 10.1038/s41584-023-01016-1.

 

FitzGerald O, Behrens F, Barton A, Bertheussen H, Boutouyrie-Dumont B, Coates L, Davies O, de Wit M, Fagni F, Goodyear CS, Gurke R, Hahnefeld L, Huppertz C, Ioannidis V, Ibberson M, Katz A, Klippstein M, Koehm M, Korish S, Mackay S, Martin DA, O'Sullivan D, Patel K, Rueping S, Schett G, Scholich K, Schwenk JM, Siebert S, Simon D, Vivekanantham A, Pennington SR. Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis.
Ther Adv Musculoskelet Dis. 2023 Sep 8;15:1759720X231192315.
doi: 10.1177/1759720X231192315.