Publications Translational Medicine

as institute branch of Fraunhofer IME

A - C

Agueusop, I., Musholt, P.B., Klaus, B., Hightower, K., Kannt, A.
Short-term variability of the human serum metabolome depending on nutritional and metabolic health status (2020) Scientific reports, 10 (1), 16310. https://doi.org/10.1038/s41598-020-72914-7

Aguilar, R.C., Salmanton-García, J., Carney, J., Böll, B., Kochanek, M., Jazmati, N., Cornely, O.A., Vehreschild, M.J.G.T.
Clostridioides difficile infections in the intensive care unit: a monocentric cohort study (2020) Infection, 48 (3), 421–427. https://doi.org/10.1007/s15010-020-01413-8

Allanore, Y., Bozzi, S., Terlinden, A., Huscher, D., Amand, C., Soubrane, C., Siegert, E., Czirják, L., Carreira, P.E., Hachulla, E., Zanatta, E., Li, M., Airò, P., Mendoza, F.A., Rosato, E., Distler, O.
Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database (2020) Arthritis research & therapy, 22 (1), 257. https://doi.org/10.1186/s13075-020-02329-2

Anastasiou, O.E., Thodou, V., Berger, A., Wedemeyer, H., Ciesek, S.
Comprehensive Evaluation of Hepatitis E Serology and Molecular Testing in a Large Cohort (2020) Pathogens (Basel, Switzerland), 9 (2). https://doi.org/10.3390/pathogens9020137

Anders, M., Anders, B., Kreuzer, M., Zinn, S., Walter, C.
Application of Referencing Techniques in EEG-Based Recordings of Contact Heat Evoked Potentials (CHEPS) (2020) Frontiers in human neuroscience, 14, 559969. https://doi.org/10.3389/fnhum.2020.559969

Appelt-Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., Pless, O.
Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development? (2020) Current protocols in stem cell biology, 55 (1), e122. https://doi.org/10.1002/cpsc.122

Assmann, G., Köhm, M., Schuster, V., Behrens, F., Mössner, R., Magnolo, N., Oji, V., Burkhardt, H., Hüffmeier, U.
Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups (2020) BMC medical genetics, 21 (1), 102. https://doi.org/10.1186/s12881-020-01037-7

Bacher, P., Rosati, E., Esser, D., Martini, G.R., Saggau, C., Schiminsky, E., Dargvainiene, J., Schröder, I., Wieters, I., Khodamoradi, Y., Eberhardt, F., Vehreschild, Maria J G T, Neb, H., Sonntagbauer, M., Conrad, C., Tran, F., Rosenstiel, P., Markewitz, R., Wandinger, K.-P., Augustin, M., Rybniker, J., Kochanek, M., Leypoldt, F., Cornely, O.A., Koehler, P., Franke, A., Scheffold, A.
Low-Avidity CD4(+) T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19 (2020) Immunity, 53 (6), 1258-1271.e5. https://doi.org/10.1016/j.immuni.2020.11.016

Ballo, O., Kreisel, E.-M., Eladly, F., Brunnberg, U., Stratmann, J., Hunyady, P., Hogardt, M., Wichelhaus, T.A., Kempf, V.A.J., Steffen, B., Vehreschild, J.J., Vehreschild, M.J.G.T., Finkelmeier, F., Serve, H., Brandts, C.H.
Use of carbapenems and glycopeptides increases risk for Clostridioides difficile infections in acute myeloid leukemia patients undergoing intensive induction chemotherapy (2020) Annals of hematology, 99 (11), 2547–2553. https://doi.org/10.1007/s00277-020-04274-1

Baraliakos, X., Sewerin, P., Miguel, E. de, Pournara, E., Kleinmond, C., Wiedon, A., Behrens, F.
Achilles tendon enthesitis evaluated by MRI assessments in patients with axial spondyloarthritis and psoriatic arthritis: a report of the methodology of the ACHILLES trial (2020) BMC musculoskeletal disorders, 21 (1), 767. https://doi.org/10.1186/s12891-020-03775-4

Basavarajappa, D., Uebbing, S., Kreiss, M., Lukic, A., Suess, B., Steinhilber, D., Samuelsson, B., Rådmark, O.
Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells (2020) Proceedings of the National Academy of Sciences of the United States of America, 117 (15), 8573–8583. https://doi.org/10.1073/pnas.1916249117

Behrens, F., Rech, J., Thaçi, D., Zinke, S., Rothnie, K.J., Oefner Daamen, C., Leipe, J.
High rates of therapeutic changes in patients with psoriatic arthritis receiving treatment with disease-modifying antirheumatic drugs: a cross-sectional study (2020) Modern rheumatology, 1–23. https://doi.org/10.1080/14397595.2020.1816597

Behrens, F., Tony, H.-P., Koehm, M., Schwaneck, E.C., Gnann, H., Greger, G., Burkhardt, H., Schmalzing, M.
Correction to: Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study (2020) Clinical rheumatology, 39 (8), 2491. https://doi.org/10.1007/s10067-020-05168-3

Behrens, F., Tony, H.-P., Koehm, M., Schwaneck, E.C., Gnann, H., Greger, G., Burkhardt, H., Schmalzing, M.
Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study (2020) Clinical rheumatology, 39 (9), 2583–2592. https://doi.org/10.1007/s10067-020-05038-y

Biehl, L.M., Vehreschild, Maria J G T
Contact precautions: no benefits, no indication (2020) The Lancet. Infectious diseases, 20 (5), 516–517. https://doi.org/10.1016/S1473-3099(20)30017-7

Blum, L., Geisslinger, G., Parnham, M.J., Grünweller, A., Schiffmann, S.
Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells (2020) Journal of cellular and molecular medicine, 24 (12), 6988–6999. https://doi.org/10.1111/jcmm.15360

Blum, L., Gul, S., Ulshöfer, T., Henke, M., Krieg, R., Berneburg, I., Thomas, D., Trautmann, S., Kurz, J., Geyer, J., Geisslinger, G., Becker, K., Parnham, M.J., Schiffmann, S.
In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o (2020) Scientific reports, 10 (1), 7534. https://doi.org/10.1038/s41598-020-64382-w

Bojkova, D., Bechtel, M., McLaughlin, K.-M., McGreig, J.E., Klann, K., Bellinghausen, C., Rohde, G., Jonigk, D., Braubach, P., Ciesek, S., Münch, C., Wass, M.N., Michaelis, M., Cinatl, J., JR
Aprotinin Inhibits SARS-CoV-2 Replication (2020) Cells, 9 (11). https://doi.org/10.3390/cells9112377

Bojkova, D., Klann, K., Koch, B., Widera, M., Krause, D., Ciesek, S., Cinatl, J., Münch, C.
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets (2020) Nature, 583 (7816), 469–472. https://doi.org/10.1038/s41586-020-2332-7

Bojkova, D., Wagner, J.U.G., Shumliakivska, M., Aslan, G.S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M.D., Krishnan, J., Harter, P.N., Ermel, U.H., Frangakis, A.S., Milting, H., Zeiher, A.M., Klingel, K., Cinatl, J., Dendorfer, A., Eschenhagen, T., Tschöpe, C., Ciesek, S., Dimmeler, S.
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes (2020) Cardiovascular research, 116 (14), 2207–2215. https://doi.org/10.1093/cvr/cvaa267

Bojkova, D., Westhaus, S., Costa, R., Timmer, L., Funkenberg, N., Korencak, M., Streeck, H., Vondran, F., Broering, R., Heinrichs, S., Lang, K.S., Ciesek, S.
Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes (2020) Cells, 9 (4). https://doi.org/10.3390/cells9041003

Brandt, S.C., Ellinger, B., van Nguyen, T., Harder, S., Schlüter, H., Hahnke, R.L., Rühl, M., Schäfer, W., Gand, M.
Aspergillus sydowii: Genome Analysis and Characterization of Two Heterologous Expressed, Non-redundant Xylanases (2020) Frontiers in microbiology, 11, 2154. https://doi.org/10.3389/fmicb.2020.573482

Brunst, S., Kramer, J.S., Kilu, W., Heering, J., Pollinger, J., Hiesinger, K., George, S., Steinhilber, D., Merk, D., Proschak, E.
Systematic Assessment of Fragment Identification for Multitarget Drug Design (2020) ChemMedChem . https://doi.org/10.1002/cmdc.202000858

Bütikofer, L., Varisco, P.A., Distler, O., Kowal-Bielecka, O., Allanore, Y., Riemekasten, G., Villiger, P.M., Adler, S.
ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis (2020) Arthritis research & therapy, 22 (1), 59. https://doi.org/10.1186/s13075-020-2141-2

Chachulski, L., Windshügel, B.
LEADS-FRAG: A Benchmark Data Set for Assessment of Fragment Docking Performance (2020) Journal of chemical information and modeling, 60 (12), 6544–6554. https://doi.org/10.1021/acs.jcim.0c00693

Chaikuad, A., Pollinger, J., Rühl, M., Ni, X., Kilu, W., Heering, J., Merk, D.
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms (2020) International journal of molecular sciences, 21 (22). https://doi.org/10.3390/ijms21228457

Charoo, N.A., Abdallah, D.B., Parveen, T., Abrahamsson, B., Cristofoletti, R., Groot, D.W., Langguth, P., Parr, A., Polli, J.E., Mehta, M., Shah, V.P., Tajiri, T., Dressman, J.
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride (2020) Journal of pharmaceutical sciences, 109 (9), 2654–2675. https://doi.org/10.1016/j.xphs.2020.06.007

Cinque, L., Leonibus, C. de, Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F.G., Cegli, R. de, Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L.G., Huebner, A.K., Cesana, M., Bonn, F., Polishchuk, E., Hübner, C.A., Conte, I., Dikic, I., Mann, M., Ballabio, A., Sacco, F., Grumati, P., Settembre, C.
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B (2020) The EMBO journal, 39 (17), e105696. https://doi.org/10.15252/embj.2020105696

Cohnen, J., Kornstädt, L., Hahnefeld, L., Ferreiros, N., Pierre, S., Koehl, U., Deller, T., Geisslinger, G., Scholich, K.
Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves (2020) Cells, 9 (2). https://doi.org/10.3390/cells9020320

Corman, V.M., Rabenau, H.F., Adams, O., Oberle, D., Funk, M.B., Keller-Stanislawski, B., Timm, J., Drosten, C., Ciesek, S.
SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission (2020) Transfusion, 60 (6), 1119–1122. https://doi.org/10.1111/trf.15841

Cruz-Aguilar, R., Carney, J., Mondaini, V., Vehreschild, M.J.G.T., Griskaitis, M., Salmanton-García, J., Böll, B., Kochanek, M., Seifert, H., Biehl, L.M., Farowski, F.
A quality improvement study on the reduction of central venous catheter-associated bloodstream infections by use of self-disinfecting venous access caps (STERILE) (2020) American journal of infection control . https://doi.org/10.1016/j.ajic.2020.09.002

D - F

Dauth, S., Rakov, H., Sîrbulescu, R.F., Ilieş, I., Weber, J., Batbajar Dugershaw, B., Braun, D., Rehders, M., Wirth, E.K., Führer, D., Schweizer, U., Brix, K.
Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland (2020) Cellular and molecular neurobiology, 40 (5), 695–710. https://doi.org/10.1007/s10571-019-00765-6

Davies, K., Lawrence, J., Berry, C., Davis, G., Yu, H., Cai, B., Gonzalez, E., Prantner, I., Kurcz, A., Macovei, I., Pituch, H., Nováková, E., Nyč, O., Gärtner, B., Berger, F.K., Oleastro, M., Cornely, O.A., Vehreschild, M.J.G.T., Pedneault, L., Wilcox, M.
Risk Factors for Primary Clostridium difficile Infection; Results From the Observational Study of Risk Factors for Clostridium difficile Infection in Hospitalized Patients With Infective Diarrhea (ORCHID) (2020) Frontiers in public health, 8, 293. https://doi.org/10.3389/fpubh.2020.00293

de Los Reyes Jiménez, Marta, Lechner, A., Alessandrini, F., Bohnacker, S., Schindela, S., Trompette, A., Haimerl, P., Thomas, D., Henkel, F., Mourão, A., Geerlof, A., Da Costa, C.P., Chaker, A.M., Brüne, B., Nüsing, R., Jakobsson, P.-J., Nockher, W.A., Feige, M.J., Haslbeck, M., Ohnmacht, C., Marsland, B.J., Voehringer, D., Harris, N.L., Schmidt-Weber, C.B., Esser-von Bieren, J.
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products (2020) Science translational medicine, 12 (540). https://doi.org/10.1126/scitranslmed.aay0605

Demir, M., Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M.J.G.T., Krawczyk, M., Nowag, A., Scholz, C.J., Kretzschmar, A., Roderburg, C., Lammert, F., Goeser, T., Kasper, P., Steffen, H.-M.
Phenotyping non-alcoholic fatty liver disease by the gut microbiota: Ready for prime time? (2020) Journal of gastroenterology and hepatology, 35 (11), 1969–1977. https://doi.org/10.1111/jgh.15071

Duriez, M., Jacquet, A., Hoet, L., Roche, S., Bock, M.-D., Rocher, C., Haussy, G., Vigé, X., Bocskei, Z., Slavnic, T., Martin, V., Guillemot, J.-C., Didier, M., Kannt, A., Orsini, C., Mikol, V., Le Fèvre, A.-C.
A 3D Human Liver Model of Nonalcoholic Steatohepatitis (2020) Journal of clinical and translational hepatology, 8 (4), 359–370. https://doi.org/10.14218/JCTH.2020.00015

Ebert, R., Cumbana, R., Lehmann, C., Kutzner, L., Toewe, A., Ferreirós, N., Parnham, M.J., Schebb, N.H., Steinhilber, D., Kahnt, A.S.
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages (2020) Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (9), 158702. https://doi.org/10.1016/j.bbalip.2020.158702

Eis-Hübinger, A.M., Hönemann, M., Wenzel, J.J., Berger, A., Widera, M., Schmidt, B., Aldabbagh, S., Marx, B., Streeck, H., Ciesek, S., Liebert, U.G., Huzly, D., Hengel, H., Panning, M.
Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples (2020) Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 127, 104381. https://doi.org/10.1016/j.jcv.2020.104381

Ellinger, B., Pohlmann, D., Woens, J., Jäkel, F.M., Reinshagen, J., Stocking, C., Prassolov, V.S., Fehse, B., Riecken, K.
A High-Throughput HIV-1 Drug Screening Platform, Based on Lentiviral Vectors and Compatible with Biosafety Level-1 (2020) Viruses, 12 (5). https://doi.org/10.3390/v12050580

Emmerich, A.C., Wellstein, J., Ossipova, E., Baumann, I., Lengqvist, J., Kultima, K., Jakobsson, P.-J., Steinhilber, D., Saul, M.J.
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells (2020) Frontiers in pharmacology, 11, 196. https://doi.org/10.3389/fphar.2020.00196

Fiolka, T., van den Abeele, J., Augustijns, P., Arora, S., Dressman, J.
Biorelevant Two-Stage In Vitro Testing for rDCS Classification and in PBPK Modeling-Case Example Ritonavir (2020) Journal of pharmaceutical sciences, 109 (8), 2512–2526. https://doi.org/10.1016/j.xphs.2020.04.023

Frey, S., Sticht, H., Wilsmann-Theis, D., Gerschütz, A., Wolf, K., Löhr, S., Haskamp, S., Frey, B., Hahn, M., Ekici, A.B., Uebe, S., Thiel, C., Reis, A., Burkhardt, H., Behrens, F., Köhm, M., Rech, J., Schett, G., Assmann, G., Kingo, K., Kõks, S., Mössner, R., Prinz, J.C., Oji, V., Schulz, P., Muñoz, L.E., Kremer, A.E., Wenzel, J., Hüffmeier, U.
Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis (2020) The Journal of investigative dermatology, 140 (7), 1451-1455.e13. https://doi.org/10.1016/j.jid.2019.11.024

Fuhrmann, D.C., Mondorf, A., Beifuß, J., Jung, M., Brüne, B.
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis (2020) Redox biology, 36, 101670. https://doi.org/10.1016/j.redox.2020.101670

G - I

Gellrich, L., Heitel, P., Heering, J., Kilu, W., Pollinger, J., Goebel, T., Kahnt, A., Arifi, S., Pogoda, W., Paulke, A., Steinhilber, D., Proschak, E., Wurglics, M., Schubert-Zsilavecz, M., Chaikuad, A., Knapp, S., Bischoff, I., Fürst, R., Merk, D.
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ (2020) Journal of medicinal chemistry, 63 (13), 6727–6740. https://doi.org/10.1021/acs.jmedchem.9b02150

Gerstein, H.C., Paré, G., McQueen, M.J., Lee, S.F., Bangdiwala, S.I., Kannt, A., Hess, S.
Novel Biomarkers for Change in Renal Function in People With Dysglycemia (2020) Diabetes care, 43 (2), 433–439. https://doi.org/10.2337/dc19-1604

Gross, T., Wack, G., Syhr, K.M.J., Tolmachova, T., Seabra, M.C., Geisslinger, G., Niederberger, E., Schmidtko, A., Kallenborn-Gerhardt, W.
Rab27a Contributes to the Processing of Inflammatory Pain in Mice (2020) Cells, 9 (6). https://doi.org/10.3390/cells9061488

Gunne, S., Heinicke, U., Parnham, M.J., Laux, V., Zacharowski, K., Knethen, A. von
Nrf2-A Molecular Target for Sepsis Patients in Critical Care (2020) Biomolecules, 10 (12). https://doi.org/10.3390/biom10121688

Hagenow, J., Hagenow, S., Grau, K., Khanfar, M., Hefke, L., Proschak, E., Stark, H.
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs (2020) Drug design, development and therapy, 14, 371–393. https://doi.org/10.2147/DDDT.S236586

Hahnefeld, L., Gruber, L., Schömel, N., Fischer, C., Mattjus, P., Gurke, R., Beretta, M., Ferreirós, N., Geisslinger, G., Wegner, M.-S.
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells (2020) The international journal of biochemistry & cell biology, 127, 105834. https://doi.org/10.1016/j.biocel.2020.105834

Hahnefeld, L., Gurke, R., Thomas, D., Schreiber, Y., Schäfer, S.M.G., Trautmann, S., Snodgrass, I.F., Kratz, D., Geisslinger, G., Ferreirós, N.
Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability? (2020) Talanta, 209, 120593. https://doi.org/10.1016/j.talanta.2019.120593

Han, Y., Huard, A., Mora, J., Da Silva, P., Brüne, B., Weigert, A.
IL-36 family cytokines in protective versus destructive inflammation (2020) Cellular signalling, 75, 109773. https://doi.org/10.1016/j.cellsig.2020.109773

Hanke, T., Cheung, S.-Y., Kilu, W., Heering, J., Ni, X., Planz, V., Schierle, S., Faudone, G., Friedrich, M., Wanior, M., Werz, O., Windbergs, M., Proschak, E., Schubert-Zsilavecz, M., Chaikuad, A., Knapp, S., Merk, D.
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode (2020) Journal of medicinal chemistry, 63 (9), 4555–4561. https://doi.org/10.1021/acs.jmedchem.9b01786

Harberts, J., Haferkamp, U., Haugg, S., Fendler, C., Lam, D., Zierold, R., Pless, O., Blick, R.H.
Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications (2020) Biomaterials science, 8 (9), 2434–2446. https://doi.org/10.1039/d0bm00182a

Hausmann, J., Kubesch, A., Goettlich, C.M., Rey, J., Wächtershäuser, A., Bojunga, J., Blumenstein, I.
Quality of life of patients with head and neck cancer after prophylactic percutaneous-gastrostomy (2020) European journal of clinical nutrition, 74 (4), 565–572. https://doi.org/10.1038/s41430-019-0499-5

Hefke, L., Hiesinger, K., Zhu, W.F., Kramer, J.S., Proschak, E.
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase (2020) ACS medicinal chemistry letters, 11 (6), 1244–1249. https://doi.org/10.1021/acsmedchemlett.0c00102

Heinen, S., Schulze, N., Franke, B., Klein, F., Lehmann, C., Vehreschild, M.J.G.T., Gloistein, C., Stecher, M., Vehreschild, J.J.
HEnRY: a DZIF LIMS tool for the collection and documentation of biomaterials in multicentre studies (2020) BMC bioinformatics, 21 (1), 290. https://doi.org/10.1186/s12859-020-03596-1

Heinicke, U., Adam, E., Sonntagbauer, M., Knethen, A. von, Zacharowski, K., Neb, H.
Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience (2020) Critical care (London, England), 24 (1), 409. https://doi.org/10.1186/s13054-020-03143-7

Hernandez-Olmos, V., Heering, J., Planz, V., Liu, T., Kaps, A., Rajkumar, R., Gramzow, M., Kaiser, A., Schubert-Zsilavecz, M., Parnham, M.J., Windbergs, M., Steinhilber, D., Proschak, E.
First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters (2020) Journal of medicinal chemistry, 63 (20), 11548–11572. https://doi.org/10.1021/acs.jmedchem.0c00588

Hiesinger, K., Kramer, J.S., Beyer, S., Eckes, T., Brunst, S., Flauaus, C., Wittmann, S.K., Weizel, L., Kaiser, A., Kretschmer, S.B.M., George, S., Angioni, C., Heering, J., Geisslinger, G., Schubert-Zsilavecz, M., Schmidtko, A., Pogoryelov, D., Pfeilschifter, J., Hofmann, B., Steinhilber, D., Schwalm, S., Proschak, E.
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase (2020) Journal of medicinal chemistry, 63 (20), 11498–11521. https://doi.org/10.1021/acs.jmedchem.0c00561

Hinnah, K., Willems, S., Morstein, J., Heering, J., Hartrampf, F.W.W., Broichhagen, J., Leippe, P., Merk, D., Trauner, D.
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) (2020) Journal of medicinal chemistry, 63 (19), 10908–10920. https://doi.org/10.1021/acs.jmedchem.0c00654

Hoehl, S., Berger, A., Ciesek, S., Rabenau, H.F.
Thirty years of CMV seroprevalence-a longitudinal analysis in a German university hospital (2020) European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39 (6), 1095–1102. https://doi.org/10.1007/s10096-020-03814-x

Hoehl, S., Karaca, O., Kohmer, N., Westhaus, S., Graf, J., Goetsch, U., Ciesek, S.
Assessment of SARS-CoV-2 Transmission on an International Flight and Among a Tourist Group (2020) JAMA network open, 3 (8), e2018044. https://doi.org/10.1001/jamanetworkopen.2020.18044

Hoehl, S., Rabenau, H., Berger, A., Kortenbusch, M., Cinatl, J., Bojkova, D., Behrens, P., Böddinghaus, B., Götsch, U., Naujoks, F., Neumann, P., Schork, J., Tiarks-Jungk, P., Walczok, A., Eickmann, M., Vehreschild, Maria J G T, Kann, G., Wolf, T., Gottschalk, R., Ciesek, S.
Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China (2020) The New England journal of medicine, 382 (13), 1278–1280. https://doi.org/10.1056/NEJMc2001899

Hofsäss, M.A., Dressman, J.
Evaluation of Differences in Dosage Form Performance of Generics Using BCS-Based Biowaiver Specifications and Biopharmaceutical Modeling-Case Examples Amoxicillin and Doxycycline (2020) Journal of pharmaceutical sciences, 109 (8), 2437–2453. https://doi.org/10.1016/j.xphs.2020.04.011

Hofsäss, M.A., Dressman, J.
Suitability of the z-Factor for Dissolution Simulation of Solid Oral Dosage Forms: Potential Pitfalls and Refinements (2020) Journal of pharmaceutical sciences, 109 (9), 2735–2745. https://doi.org/10.1016/j.xphs.2020.05.019

Hotter, G., Mastora, C., Jung, M., Brüne, B., Carbonell, T., Josa, C., Pérez-Calvo, J.I., Cruzado, J.M., Guiteras, R., Sola, A.
The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation (2020) Scientific reports, 10 (1), 15302. https://doi.org/10.1038/s41598-020-72342-7

Huber, J., Obata, M., Gruber, J., Akutsu, M., Löhr, F., Rogova, N., Güntert, P., Dikic, I., Kirkin, V., Komatsu, M., Dötsch, V., Rogov, V.V.
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5 (2020) Autophagy, 16 (2), 256–270. https://doi.org/10.1080/15548627.2019.1606637

Hughes, M., Heal, C., Siegert, E., Hachulla, E., Airó, P., Riccardi, A., Distler, O., Matucci-Cerinic, M.
Significant weight loss in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database (2020) Annals of the rheumatic diseases, 79 (8), 1123–1125. https://doi.org/10.1136/annrheumdis-2020-217035

Ingelfinger, R., Henke, M., Roser, L., Ulshöfer, T., Calchera, A., Singh, G., Parnham, M.J., Geisslinger, G., Fürst, R., Schmitt, I., Schiffmann, S.
Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach (2020) Frontiers in pharmacology, 11, 1322. https://doi.org/10.3389/fphar.2020.01322

J - L

Janssen, M., Schäkel, U., Djuka Fokou, C., Krisam, J., Stermann, J., Kriegsmann, K., Haberbosch, I., Novotny, J.P., Weber, S., Vehreschild, M., Bornhäuser, M., Bullinger, L., Schmitt, M., Liebregts, T., Dreger, P., Lorenz, H.-M., Plaszczyca, A., Bartenschlager, R., Müller, B., Kräusslich, H.-G., Halama, N., Jäger, D., Schlenk, R.F., Leo, A., Meuer, S., Weigand, M.A., Motsch, J., Merle, U., Denkinger, C.M., Müller-Tidow, C.
A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial (2020) Trials, 21 (1), 828. https://doi.org/10.1186/s13063-020-04735-y

Kallenborn-Gerhardt, W., Metzner, K., Lu, R., Petersen, J., Kuth, M.S., Heine, S., Drees, O., Paul, M., Becirovic, E., Kennel, L., Flauaus, C., Gross, T., Wack, G., Hohmann, S.W., Nemirovski, D., Del Turco, D., Biel, M., Geisslinger, G., Michalakis, S., Schmidtko, A.
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1 (2020) Neuropharmacology, 171, 108087. https://doi.org/10.1016/j.neuropharm.2020.108087

Kannt, A., Madsen, A.N., Kammermeier, C., Elvert, R., Klöckener, T., Bossart, M., Haack, T., Evers, A., Lorenz, K., Hennerici, W., Rocher, C., Böcskei, Z., Guillemot, J.-C., Mikol, V., Pattou, F., Staels, B., Wagner, M.
Incretin combination therapy for the treatment of non-alcoholic steatohepatitis (2020) Diabetes, obesity & metabolism, 22 (8), 1328–1338. https://doi.org/10.1111/dom.14035

Karathanasis, C., Medler, J., Fricke, F., Smith, S., Malkusch, S., Widera, D., Fulda, S., Wajant, H., van Wijk, Sjoerd J L, Dikic, I., Heilemann, M.
Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells (2020) Science signaling, 13 (614). https://doi.org/10.1126/scisignal.aax5647

Kedor, C., Listing, J., Zernicke, J., Weiß, A., Behrens, F., Blank, N., Henes, J.C., Kekow, J., Rubbert-Roth, A., Schulze-Koops, H., Seipelt, E., Specker, C., Feist, E.
Canakinumab for Treatment of Adult-Onset Still's Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial (2020) Annals of the rheumatic diseases, 79 (8), 1090–1097. https://doi.org/10.1136/annrheumdis-2020-217155

Keller, J.J., Ooijevaar, R.E., Hvas, C.L., Terveer, E.M., Lieberknecht, S.C., Högenauer, C., Arkkila, P., Sokol, H., Gridnyev, O., Mégraud, F., Kump, P.K., Nakov, R., Goldenberg, S.D., Satokari, R., Tkatch, S., Sanguinetti, M., Cammarota, G., Dorofeev, A., Gubska, O., Ianiro, G., Mattila, E., Arasaradnam, R.P., Sarin, S.K., Sood, A., Putignani, L., Alric, L., Baunwall, S.M., Kupcinskas, J., Link, A., Goorhuis, A.G., Verspaget, H.W., Ponsioen, C., Hold, G.L., Tilg, H., Kassam, Z., Kuijper, E.J., Gasbarrini, A., Mulder, C.J., Williams, H.R., Vehreschild, M.J.
A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group (2020) United European gastroenterology journal, 2050640620967898. https://doi.org/10.1177/2050640620967898

Keller, J.J., Vehreschild, M.J., Hvas, C.L., Jørgensen, S.M., Kupcinskas, J., Link, A., Mulder, C.J., Goldenberg, S.D., Arasaradnam, R., Sokol, H., Gasbarrini, A., Hoegenauer, C., Terveer, E.M., Kuijper, E.J., Arkkila, P.
Donated stool for faecal microbiota transplantation is not a drug, but guidance and regulation are needed (2020) United European gastroenterology journal, 8 (3), 353–354. https://doi.org/10.1177/2050640620910847

Keminer, O., Teigeler, M., Kohler, M., Wenzel, A., Arning, J., Kaßner, F., Windshügel, B., Eilebrecht, E.
A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes (2020) The Science of the total environment, 717, 134743. https://doi.org/10.1016/j.scitotenv.2019.134743

Kesavan, R., Frömel, T., Zukunft, S., Laban, H., Geyer, A., Naeem, Z., Heidler, J., Wittig, I., Elwakeel, E., Brüne, B., Weigert, A., Popp, R., Fleming, I.
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer (2020) Proceedings of the National Academy of Sciences of the United States of America, 117 (11), 5923–5930. https://doi.org/10.1073/pnas.1921381117

Kikuchi-Taura, A., Okinaka, Y., Takeuchi, Y., Ogawa, Y., Maeda, M., Kataoka, Y., Yasui, T., Kimura, T., Gul, S., Claussen, C., Boltze, J., Taguchi, A.
Bone Marrow Mononuclear Cells Activate Angiogenesis via Gap Junction-Mediated Cell-Cell Interaction (2020) Stroke, 51 (4), 1279–1289. https://doi.org/10.1161/STROKEAHA.119.028072

Kim, R.Q., Misra, M., Gonzalez, A., Tomašković, I., Shin, D., Schindelin, H., Filippov, D.V., Ovaa, H., Đikić, I., van der Heden van Noort, Gerbrand J
Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection (2020) Chemistry (Weinheim an der Bergstrasse, Germany) . https://doi.org/10.1002/chem.202004590

Klann, K., Bojkova, D., Tascher, G., Ciesek, S., Münch, C., Cinatl, J.
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication (2020) Molecular cell, 80 (1), 164-174.e4. https://doi.org/10.1016/j.molcel.2020.08.006

Klatt-Schreiner, K., Valek, L., Kang, J.-S., Khlebtovsky, A., Trautmann, S., Hahnefeld, L., Schreiber, Y., Gurke, R., Thomas, D., Wilken-Schmitz, A., Wicker, S., Auburger, G., Geisslinger, G., Lötsch, J., Pfeilschifter, W., Djaldetti, R., Tegeder, I.
High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease (2020) Movement disorders : official journal of the Movement Disorder Society, 35 (10), 1822–1833. https://doi.org/10.1002/mds.28186

Klippenstein, V., Ciesek, S., Riemann, J.F.
COVID-19 – eine Multiorganerkrankung stellt das Gesundheitssystem auf die Probe (2020) Der Gastroenterologe : Zeitschrift fur Gastroenterologie und Hepatologie, 15 (6), 441–442. https://doi.org/10.1007/s11377-020-00487-y

Klitsch, A., Evdokimov, D., Frank, J., Thomas, D., Saffer, N., Meyer Zu Altenschildesche, C., Sisignano, M., Kampik, D., Malik, R.A., Sommer, C., Üçeyler, N.
Reduced association between dendritic cells and corneal sub-basal nerve fibers in patients with fibromyalgia syndrome (2020) Journal of the peripheral nervous system : JPNS, 25 (1), 9–18. https://doi.org/10.1111/jns.12360

Klöß, S., Dehmel, S., Braun, A., Parnham, M.J., Köhl, U., Schiffmann, S.
From Cancer to Immune-Mediated Diseases and Tolerance Induction: Lessons Learned From Immune Oncology and Classical Anti-cancer Treatment (2020) Frontiers in immunology, 11, 1423. https://doi.org/10.3389/fimmu.2020.01423

Klumpp, L., Dressman, J.
Physiologically based pharmacokinetic model outputs depend on dissolution data and their input: Case examples glibenclamide and dipyridamole (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 151, 105380. https://doi.org/10.1016/j.ejps.2020.105380

Klumpp, L., Leigh, M., Dressman, J.
Dissolution behavior of various drugs in different FaSSIF versions (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 142, 105138. https://doi.org/10.1016/j.ejps.2019.105138

Knethen, A. von, Heinicke, U., Weigert, A., Zacharowski, K., Brüne, B.
Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells (2020) International journal of molecular sciences, 21 (7). https://doi.org/10.3390/ijms21072356

Koehm, M., McIntosh, M.J., Hofmann, M.W., Abraham, V., Gabay, C., Choy, E.H., Kavanaugh, A., Burkhardt, H., Behrens, F.
Individual therapeutic DAS28-d(crit) responses differentiate between effectiveness of rheumatoid arthritis therapies and reflect patient-reported outcomes: retrospective analysis of DAS28 responses in comparative tocilizumab studies (2020) Rheumatology international, 40 (5), 747–755. https://doi.org/10.1007/s00296-020-04514-7

Köhm, M., Burkhardt, H., Behrens, F.
Treatment strategies in psoriatic arthritis (2020) Deutsche medizinische Wochenschrift (1946), 145 (11), 773–780. https://doi.org/10.1055/a-0964-0231

Köhm, M., Zerweck, L., Ngyuen, P.-H., Burkhardt, H., Behrens, F.
Innovative Imaging Technique for Visualization of Vascularization and Established Methods for Detection of Musculoskeletal Inflammation in Psoriasis Patients (2020) Frontiers in medicine, 7, 468. https://doi.org/10.3389/fmed.2020.00468

Kohmer, N., Westhaus, S., Rühl, C., Ciesek, S., Rabenau, H.F.
Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays (2020) Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 129, 104480. https://doi.org/10.1016/j.jcv.2020.104480

Kohmer, N., Westhaus, S., Rühl, C., Ciesek, S., Rabenau, H.F.
Clinical performance of different SARS-CoV-2 IgG antibody tests (2020) Journal of medical virology, 92 (10), 2243–2247. https://doi.org/10.1002/jmv.26145

Kreer, C., Zehner, M., Weber, T., Ercanoglu, M.S., Gieselmann, L., Rohde, C., Halwe, S., Korenkov, M., Schommers, P., Vanshylla, K., Di Cristanziano, V., Janicki, H., Brinker, R., Ashurov, A., Krähling, V., Kupke, A., Cohen-Dvashi, H., Koch, M., Eckert, J.M., Lederer, S., Pfeifer, N., Wolf, T., Vehreschild, M.J.G.T., Wendtner, C., Diskin, R., Gruell, H., Becker, S., Klein, F.
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients (2020) Cell, 182 (6), 1663–1673. https://doi.org/10.1016/j.cell.2020.08.046

Kreer, C., Zehner, M., Weber, T., Ercanoglu, M.S., Gieselmann, L., Rohde, C., Halwe, S., Korenkov, M., Schommers, P., Vanshylla, K., Di Cristanziano, V., Janicki, H., Brinker, R., Ashurov, A., Krähling, V., Kupke, A., Cohen-Dvashi, H., Koch, M., Eckert, J.M., Lederer, S., Pfeifer, N., Wolf, T., Vehreschild, Maria J G T, Wendtner, C., Diskin, R., Gruell, H., Becker, S., Klein, F.
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients (2020) Cell, 182 (4), 843-854.e12. https://doi.org/10.1016/j.cell.2020.06.044

Kriesel, F., Stegmann, L., Ciesek, S., Kaderali, L., Baldauf, H.-M.
Efficient inactivation of pseudotyped HIV-based lentiviral vectors and infectious HIV (2020) Journal of virological methods, 276, 113768. https://doi.org/10.1016/j.jviromet.2019.113768

Kubesch, A., Boulahrout, P., Filmann, N., Blumenstein, I., Hausmann, J.
Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort (2020) PloS one, 15 (1), e0227309. https://doi.org/10.1371/journal.pone.0227309

Kuijper, E.J., Vehreschild, Maria J G T
Clinical microbiota and infection (2020) Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 26 (11), 1447. https://doi.org/10.1016/j.cmi.2020.09.029

Lang, S., Farowski, F., Martin, A., Wisplinghoff, H., Vehreschild, M.J.G.T., Krawczyk, M., Nowag, A., Kretzschmar, A., Scholz, C., Kasper, P., Roderburg, C., Lammert, F., Goeser, T., Steffen, H.-M., Demir, M.
Prediction of advanced fibrosis in non-alcoholic fatty liver disease using gut microbiota-based approaches compared with simple non-invasive tools (2020) Scientific reports, 10 (1), 9385. https://doi.org/10.1038/s41598-020-66241-0

Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M.J.G.T., Liu, J., Krawczyk, M., Nowag, A., Kretzschmar, A., Herweg, J., Schnabl, B., Tu, X.M., Lammert, F., Goeser, T., Tacke, F., Heinzer, K., Kasper, P., Steffen, H.-M., Demir, M.
High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD (2020) Hepatology communications, 4 (5), 681–695. https://doi.org/10.1002/hep4.1509

Lerch, F., Ultsch, A., Lötsch, J.
Distribution Optimization: An evolutionary algorithm to separate Gaussian mixtures (2020) Scientific reports, 10 (1), 648. https://doi.org/10.1038/s41598-020-57432-w

Lin, J., Hu, J., Schlotterer, A., Wang, J., Kolibabka, M., Awwad, K., Dietrich, N., Breitschopf, K., Wohlfart, P., Kannt, A., Lorenz, K., Feng, Y., Popp, R., Hoffmann, S., Fleming, I., Hammes, H.P.
Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease (2020) Theranostics, 10 (17), 7857–7871. https://doi.org/10.7150/thno.43154

Linciano, P., Cullia, G., Borsari, C., Santucci, M., Ferrari, S., Witt, G., Gul, S., Kuzikov, M., Ellinger, B., Santarém, N., Da Cordeiro Silva, A., Conti, P., Bolognesi, M.L., Roberti, M., Prati, F., Bartoccini, F., Retini, M., Piersanti, G., Cavalli, A., Goldoni, L., Bertozzi, S.M., Bertozzi, F., Brambilla, E., Rizzo, V., Piomelli, D., Pinto, A., Bandiera, T., Costi, M.P.
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign (2020) European journal of medicinal chemistry, 189, 112047. https://doi.org/10.1016/j.ejmech.2020.112047

Litou, C., Psachoulias, D., Vertzoni, M., Dressman, J., Reppas, C.
Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults (2020) Pharmaceutical research, 37 (3), 42. https://doi.org/10.1007/s11095-019-2731-3

Litou, C., Turner, D.B., Holmstock, N., Ceulemans, J., Box, K.J., Kostewicz, E., Kuentz, M., Holm, R., Dressman, J.
Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 149, 105297. https://doi.org/10.1016/j.ejps.2020.105297

Loisios-Konstantinidis, I., Cristofoletti, R., Fotaki, N., Turner, D.B., Dressman, J.
Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. case example: Naproxen (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 143, 105170. https://doi.org/10.1016/j.ejps.2019.105170

Loisios-Konstantinidis, I., Cristofoletti, R., Jamei, M., Turner, D., Dressman, J.
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen (2020) Pharmaceutics, 12 (11). https://doi.org/10.3390/pharmaceutics12111049

López, M., Heitmeier, S., Laux, V., Nowak, G.
The dual FXa/thrombin inhibitor SATI prevents fibrin and platelet deposition in hypercoagulant rats (2020) Thrombosis research, 193, 15–21. https://doi.org/10.1016/j.thromres.2020.05.016

Lötsch, J., Hummel, T.
A data science-based analysis of seasonal patterns in outpatient presentations due to olfactory dysfunction (2020) Rhinology, 58 (2), 151–157. https://doi.org/10.4193/Rhin19.099.

Lötsch, J., Alfredsson, L., Lampa, J.
Machine-learning-based knowledge discovery in rheumatoid arthritis-related registry data to identify predictors of persistent pain (2020) Pain, 161 (1), 114–126. https://doi.org/10.1097/j.pain.0000000000001693

Lötsch, J., Geisslinger, G., Walter, C.
Pain models and clinical pain research are not contradictory (2020) Schmerz (Berlin, Germany), 34 (3), 281. https://doi.org/10.1007/s00482-020-00452-2

Lötsch, J., Haehner, A., Hummel, T.
Machine-learning-derived rules set excludes risk of Parkinson's disease in patients with olfactory or gustatory symptoms with high accuracy (2020) Journal of neurology, 267 (2), 469–478. https://doi.org/10.1007/s00415-019-09604-6.

Lötsch, J., Kringel, D., Geisslinger, G., Oertel, B.G., Resch, E., Malkusch, S.
Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes (2020) International journal of molecular sciences, 21 (12). https://doi.org/10.3390/ijms21124367

Lötsch, J., Malkusch, S.
Interpretation of cluster structures in pain-related phenotype data using explainable artificial intelligence (XAI) (2020) European journal of pain (London, England) . https://doi.org/10.1002/ejp.1683

Lötsch, J., Oertel, B.G., Felden, L., Nöth, U., Deichmann, R., Hummel, T., Walter, C.
Central encoding of the strength of intranasal chemosensory trigeminal stimuli in a human experimental pain setting (2020) Human brain mapping, 41 (18), 5240–5254. https://doi.org/10.1002/hbm.25190

Lötsch, J., Ultsch, A.
A non-parametric effect-size measure capturing changes in central tendency and data distribution shape (2020) PloS one, 15 (9), e0239623. https://doi.org/10.1371/journal.pone.0239623

Lötsch, J., Ultsch, A., Kalso, E.
Data-science-based subgroup analysis of persistent pain during 3 years after breast cancer surgery: A prospective cohort study (2020) European journal of anaesthesiology, 37 (3), 235–246. https://doi.org/10.1097/EJA.0000000000001116

Lötsch, J., Walter, C., Zunftmeister, M., Zinn, S., Wolters, M., Ferreiros, N., Rossmanith, T., Oertel, B.G., Geisslinger, G.
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects (2020) Basic & clinical pharmacology & toxicology, 126 (4), 318–331. https://doi.org/10.1111/bcpt.13337

Luo, C., Pook, E., Wang, F., Archacki, S.R., Tang, B., Zhang, W., Hu, J.-S., Yang, J., Leineweber, K., Bechem, M., Huang, W., Song, Y., Cheung, S.-H., Laux, V., Ke, T., Ren, X., Tu, X., Chen, Q., Wang, Q.K., Xu, C.
ADTRP regulates TFPI expression via transcription factor POU1F1 involved in coronary artery disease (2020) Gene, 753, 144805. https://doi.org/10.1016/j.gene.2020.144805

Lütjohann, D., Stellaard, F., Kerksiek, A., Lötsch, J., Oertel, B.G.
Serum 4β-hydroxycholesterol increases during fluconazole treatment (2020) European journal of clinical pharmacology . https://doi.org/10.1007/s00228-020-03041-5

M - O

Maculins, T., Garcia-Pardo, J., Skenderovic, A., Gebel, J., Putyrski, M., Vorobyov, A., Busse, P., Varga, G., Kuzikov, M., Zaliani, A., Rahighi, S., Schaeffer, V., Parnham, M.J., Sidhu, S.S., Ernst, A., Dötsch, V., Akutsu, M., Dikic, I.
Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms (2020) Cell chemical biology, 27 (11), 1441-1451.e7. https://doi.org/10.1016/j.chembiol.2020.07.010

Marbach-Breitrück, E., Kutzner, L., Rothe, M., Gurke, R., Schreiber, Y., Reddanna, P., Schebb, N.-H., Stehling, S., Wieler, L.H., Heydeck, D., Kuhn, H.
Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme (2020) Antioxidants & redox signaling, 32 (1), 1–17. https://doi.org/10.1089/ars.2019.7751

McInnes, I.B., Behrens, F., Mease, P.J., Kavanaugh, A., Ritchlin, C., Nash, P., Masmitja, J.G., Goupille, P., Korotaeva, T., Gottlieb, A.B., Martin, R., Ding, K., Pellet, P., Mpofu, S., Pricop, L.
Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial (2020) Lancet (London, England), 395 (10235), 1496–1505. https://doi.org/10.1016/S0140-6736(20)30564-X

McLaughlin, K.-M., Bechtel, M., Bojkova, D., Münch, C., Ciesek, S., Wass, M.N., Michaelis, M., Cinatl, J., JR
COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? (2020) Diagnostics (Basel, Switzerland), 10 (8). https://doi.org/10.3390/diagnostics10080539

Mease, P.J., Gladman, D.D., Ogdie, A., Coates, L.C., Behrens, F., Kavanaugh, A., McInnes, I., Queiro, R., Guerette, B., Brunori, M., Teng, L., Smolen, J.S.
Treatment-to-Target With Apremilast in Psoriatic Arthritis: The Probability of Achieving Targets and Comprehensive Control of Disease Manifestations (2020) Arthritis care & research, 72 (6), 814–821. https://doi.org/10.1002/acr.24134

Mease, P.J., Smolen, J.S., Behrens, F., Nash, P., Liu Leage, S., Li, L., Tahir, H., Gooderham, M., Krishnan, E., Liu-Seifert, H., Emery, P., Pillai, S.G., Helliwell, P.S.
A head-to-head comparison of the efficacy and safety of ixekizumab and adalimumab in biological-naïve patients with active psoriatic arthritis: 24-week results of a randomised, open-label, blinded-assessor trial (2020) Annals of the rheumatic diseases, 79 (1), 123–131. https://doi.org/10.1136/annrheumdis-2019-215386

Meijer, I., Willems, S., Ni, X., Heering, J., Chaikuad, A., Merk, D.
Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics (2020) International journal of molecular sciences, 21 (21). https://doi.org/10.3390/ijms21217895

Mertens, C., Kuchler, L., Sola, A., Guiteras, R., Grein, S., Brüne, B., Knethen, A. von, Jung, M.
Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage (2020) International journal of molecular sciences, 21 (20). https://doi.org/10.3390/ijms21207527

Meyer, S. de, Bojkova, D., Cinatl, J., van Damme, E., Buyck, C., van Loock, M., Woodfall, B., Ciesek, S.
Lack of antiviral activity of darunavir against SARS-CoV-2 (2020) International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 97, 7–10. https://doi.org/10.1016/j.ijid.2020.05.085

Mishra, A., Castañeda, T.R., Bader, E., Elshorst, B., Cummings, S., Scherer, P., Bangari, D.S., Loewe, C., Schreuder, H., Pöverlein, C., Helms, M., Jones, S., Zech, G., Licher, T., Wagner, M., Schudok, M., Hoop, M. de, Plowright, A.T., Atzrodt, J., Kannt, A., Laitinen, I., Derdau, V.
Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis (2020) Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7 (24), 2002997. https://doi.org/10.1002/advs.202002997

Möller, M., Wasel, J., Schmetzer, J., Weiß, U., Meissner, M., Schiffmann, S., Weigert, A., Möser, C.V., Niederberger, E.
The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways (2020) International journal of molecular sciences, 21 (13). https://doi.org/10.3390/ijms21134721

Mostazo, M.G.C., Kurrle, N., Casado, M., Fuhrmann, D., Alshamleh, I., Häupl, B., Martín-Sanz, P., Brüne, B., Serve, H., Schwalbe, H., Schnütgen, F., Marin, S., Cascante, M.
Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia (2020) Cancers, 12 (11). https://doi.org/10.3390/cancers12113443

Muenchhoff, M., Mairhofer, H., Nitschko, H., Grzimek-Koschewa, N., Hoffmann, D., Berger, A., Rabenau, H., Widera, M., Ackermann, N., Konrad, R., Zange, S., Graf, A., Krebs, S., Blum, H., Sing, A., Liebl, B., Wölfel, R., Ciesek, S., Drosten, C., Protzer, U., Boehm, S., Keppler, O.T.
Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020 (2020) Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25 (24). https://doi.org/10.2807/1560-7917.ES.2020.25.24.2001057

Nieraad, H., Bruin, N. de, Arne, O., Hofmann, M.C.J., Schmidt, M., Saito, T., Saido, T.C., Gurke, R., Schmidt, D., Till, U., Parnham, M.J., Geisslinger, G.
Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease (2020) Nutrients, 12 (11). https://doi.org/10.3390/nu12113248

Olesch, C., Sirait-Fischer, E., Berkefeld, M., Fink, A.F., Susen, R.M., Ritter, B., Michels, B.E., Steinhilber, D., Greten, F.R., Savai, R., Takeda, K., Brüne, B., Weigert, A.
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion (2020) The Journal of clinical investigation, 130 (10), 5461–5476. https://doi.org/10.1172/JCI136928

Osthues, T., Zimmer, B., Rimola, V., Klann, K., Schilling, K., Mathoor, P., Angioni, C., Weigert, A., Geisslinger, G., Münch, C., Scholich, K., Sisignano, M.
The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain (2020) Cells, 9 (7). https://doi.org/10.3390/cells9071740

P - R

Panova-Noeva, M., Wagner, B., Nagler, M., Koeck, T., Cate, V. ten, Prochaska, J.H., Heitmeier, S., Meyer, I., Gerdes, C., Laux, V., Konstantinides, S., Spronk, H.M., Münzel, T., Lackner, K.J., Leineweber, K., Cate, H. ten, Wild, P.S.
Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous thromboembolism - results from clinical observation studies (2020) EBioMedicine, 60, 102978. https://doi.org/10.1016/j.ebiom.2020.102978

Paraiso, R.L.M., Rose, R.H., Fotaki, N., McAllister, M., Dressman, J.B.
The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105534. https://doi.org/10.1016/j.ejps.2020.105534

Pentafragka, C., Vertzoni, M., Dressman, J., Symillides, M., Goumas, K., Reppas, C.
Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105535. https://doi.org/10.1016/j.ejps.2020.105535

Peveling-Oberhag, J., Michael, F., Tal, A., Welsch, C., Vermehren, J., Farnik, H., Grammatikos, G., Lange, C., Walter, D., Blumenstein, I., Filmann, N., Herrmann, E., Albert, J., Zeuzem, S., Bojunga, J., Friedrich-Rust, M.
Capnography monitoring of non-anesthesiologist provided sedation during percutaneous endoscopic gastrostomy placement: A prospective, controlled, randomized trial (2020) Journal of gastroenterology and hepatology, 35 (3), 401–407. https://doi.org/10.1111/jgh.14760

Pflüger-Müller, B., Oo, J.A., Heering, J., Warwick, T., Proschak, E., Günther, S., Looso, M., Rezende, F., Fork, C., Geisslinger, G., Thomas, D., Gurke, R., Steinhilber, D., Schulz, M., Leisegang, M.S., Brandes, R.P.
The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells (2020) Basic research in cardiology, 115 (3), 34. https://doi.org/10.1007/s00395-020-0793-3

Piesche, M., Roos, J., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Maucher, I.V., Awad, O., Matrone, C., Comerma Steffensen, S.G., Manolikakes, G., Heinicke, U., Zacharowski, K.D., Steinhilber, D., Maier, T.J.
The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer (2020) Frontiers in pharmacology, 11, 1297. https://doi.org/10.3389/fphar.2020.01297

Plöger, G.F., Quizon, P.M., Abrahamsson, B., Cristofoletti, R., Groot, D.W., Parr, A., Langguth, P., Polli, J.E., Shah, V.P., Tajiri, T., Mehta, M.U., Dressman, J.
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cephalexin Monohydrate (2020) Journal of pharmaceutical sciences, 109 (6), 1846–1862. https://doi.org/10.1016/j.xphs.2020.03.025

Price, D.J., Nair, A., Becker-Baldus, J., Glaubitz, C., Kuentz, M., Dressman, J., Saal, C.
Incorporation of HPMCAS during loading of glibenclamide onto mesoporous silica improves dissolution and inhibits precipitation (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 141, 105113. https://doi.org/10.1016/j.ejps.2019.105113

Puntmann, V.O., Carerj, M.L., Wieters, I., Fahim, M., Arendt, C., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa-Nicotera, M., Zeiher, A.M., Vehreschild, M., Nagel, E.
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) (2020) JAMA cardiology, 5 (11), 1265–1273. https://doi.org/10.1001/jamacardio.2020.3557

Putyrski, M., Vakhrusheva, O., Bonn, F., Guntur, S., Vorobyov, A., Brandts, C., Dikic, I., Ernst, A.
Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine (2020) Frontiers in cell and developmental biology, 8, 208. https://doi.org/10.3389/fcell.2020.00208

Queck, A., Fink, A.F., Sirait-Fischer, E., Rüschenbaum, S., Thomas, D., Snodgrass, R.G., Geisslinger, G., Baba, H.A., Trebicka, J., Zeuzem, S., Weigert, A., Lange, C.M., Brüne, B.
Alox12/15 Deficiency Exacerbates, While Lipoxin A(4) Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis (2020) Frontiers in immunology, 11, 1447. https://doi.org/10.3389/fimmu.2020.01447

Rehwald, C., Schnetz, M., Urbschat, A., Mertens, C., Meier, J.K., Bauer, R., Baer, P., Winslow, S., Roos, F.C., Zwicker, K., Huard, A., Weigert, A., Brüne, B., Jung, M.
The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma (2020) British journal of cancer, 122 (3), 421–433. https://doi.org/10.1038/s41416-019-0655-7

Reppas, C., Vrettos, N.-N., Dressman, J., Andreas, C.J., Miyaji, Y., Brown, J., Etherson, K., Hanley, S., Karkossa, F., Karlsson, E., Klein, S., Maier, G.-M., McAllister, M., Mistry, N., Rosenblatt, K., Schäfer, K.J., Smith, K.L., Tomaszewska, I., Williams, J., Winge, F., Vertzoni, M.
Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV (2020) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 156, 40–49. https://doi.org/10.1016/j.ejpb.2020.08.025

Rimola, V., Hahnefeld, L., Zhao, J., Jiang, C., Angioni, C., Schreiber, Y., Osthues, T., Pierre, S., Geisslinger, G., Ji, R.-R., Scholich, K., Sisignano, M.
Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain (2020) The Journal of neuroscience : the official journal of the Society for Neuroscience, 40 (49), 9519–9532. https://doi.org/10.1523/JNEUROSCI.1223-20.2020

Rohde, A.M., Zweigner, J., Wiese-Posselt, M., Schwab, F., Behnke, M., Kola, A., Schröder, W., Peter, S., Tacconelli, E., Wille, T., Feihl, S., Querbach, C., Gebhardt, F., Gölz, H., Schneider, C., Mischnik, A., Vehreschild, M.J.G.T., Seifert, H., Kern, W.V., Gastmeier, P., Hamprecht, A.
Prevalence of third-generation cephalosporin-resistant Enterobacterales colonization on hospital admission and ESBL genotype-specific risk factors: a cross-sectional study in six German university hospitals (2020) The Journal of antimicrobial chemotherapy, 75 (6), 1631–1638. https://doi.org/10.1093/jac/dkaa052

Ruhnke, M., Cornely, O.A., Schmidt-Hieber, M., Alakel, N., Boell, B., Buchheidt, D., Christopeit, M., Hasenkamp, J., Heinz, W.J., Hentrich, M., Karthaus, M., Koldehoff, M., Maschmeyer, G., Panse, J., Penack, O., Schleicher, J., Teschner, D., Ullmann, A.J., Vehreschild, M., Lilienfeld-Toal, M. von, Weissinger, F., Schwartz, S.
Treatment of invasive fungal diseases in cancer patients-Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) (2020) Mycoses, 63 (7), 653–682. https://doi.org/10.1111/myc.13082

Runfola, M., Sestito, S., Bellusci, L., La Pietra, V., D'Amore, V.M., Kowalik, M.A., Chiellini, G., Gul, S., Perra, A., Columbano, A., Marinelli, L., Novellino, E., Rapposelli, S.
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis (2020) European journal of medicinal chemistry, 188, 112006. https://doi.org/10.1016/j.ejmech.2019.112006

Runfola, M., Sestito, S., Gul, S., Chiellini, G., Rapposelli, S.
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics (2020) Data in brief, 29, 105206. https://doi.org/10.1016/j.dib.2020.105206

S - U

Salado, I.G., Singh, A.K., Moreno-Cinos, C., Sakaine, G., Siderius, M., van der Veken, P., an Matheeussen, van der Meer, T., Sadek, P., Gul, S., Maes, L., Sterk, G.-J., Leurs, R., Brown, D., Augustyns, K.
Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds (2020) Journal of medicinal chemistry, 63 (7), 3485–3507. https://doi.org/10.1021/acs.jmedchem.9b00985

Salazar, Y., Zheng, X., Brunn, D., Raifer, H., Picard, F., Zhang, Y., Winter, H., Guenther, S., Weigert, A., Weigmann, B., Dumoutier, L., Renauld, J.-C., Waisman, A., Schmall, A., Tufman, A., Fink, L., Brüne, B., Bopp, T., Grimminger, F., Seeger, W., Pullamsetti, S.S., Huber, M., Savai, R.
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer (2020) The Journal of clinical investigation, 130 (7), 3560–3575. https://doi.org/10.1172/JCI124037

Sargsyan, A., Kodamullil, A.T., Baksi, S., Darms, J., Madan, S., Gebel, S., Keminer, O., Jose, G.M., Balabin, H., DeLong, L.N., Kohler, M., Jacobs, M., Hofmann-Apitius, M.
The COVID-19 Ontology (2020) Bioinformatics (Oxford, England) . https://doi.org/10.1093/bioinformatics/btaa1057

Sarode, P., Zheng, X., Giotopoulou, G.A., Weigert, A., Kuenne, C., Günther, S., Friedrich, A., Gattenlöhner, S., Stiewe, T., Brüne, B., Grimminger, F., Stathopoulos, G.T., Pullamsetti, S.S., Seeger, W., Savai, R.
Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer (2020) Science advances, 6 (23), eaaz6105. https://doi.org/10.1126/sciadv.aaz6105

Schäfer, R., Spohn, G., Bechtel, M., Bojkova, D., Baer, P.C., Kuçi, S., Seifried, E., Ciesek, S., Cinatl, J.
Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells (2020) Stem cell reports . https://doi.org/10.1016/j.stemcr.2020.09.003

Schäfer, S.M.G., Sendetski, M., Angioni, C., Nüsing, R., Geisslinger, G., Scholich, K., Sisignano, M.
The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP) (2020) Neuropharmacology, 166, 107952. https://doi.org/10.1016/j.neuropharm.2020.107952

Schalk, E., Vehreschild, M.J.G.T., Biehl, L.M.
Influence of different definitions of central venous catheter-related bloodstream infections on epidemiological parameters in cancer patients (2020) Infection control and hospital epidemiology, 1–2. https://doi.org/10.1017/ice.2020.274

Schierle, S., Helmstädter, M., Schmidt, J., Hartmann, M., Horz, M., Kaiser, A., Weizel, L., Heitel, P., Proschak, A., Hernandez-Olmos, V., Proschak, E., Merk, D.
Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast (2020) ChemMedChem, 15 (1), 50–67. https://doi.org/10.1002/cmdc.201900576

Schlag, K., Steinhilber, D., Karas, M., Sorg, B.L.
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics (2020) The FEBS journal, 287 (20), 4481–4499. https://doi.org/10.1111/febs.15259

Schmalzing, M., Behrens, F., Schwaneck, E.C., Koehm, M., Greger, G., Gnann, H., Burkhardt, H., Tony, H.-P.
Does concomitant methotrexate confer clinical benefits in patients treated with prior biologic therapy? Analysis of data from a noninterventional study of rheumatoid arthritis patients initiating treatment with adalimumab (2020) Medicine, 99 (19), e20201. https://doi.org/10.1097/MD.0000000000020201

Schmidt, M., Hoehl, S., Berger, A., Zeichhardt, H., Hourfar, K., Ciesek, S., Seifried, E.
Novel multiple swab method enables high efficiency in SARS-CoV-2 screenings without loss of sensitivity for screening of a complete population (2020) Transfusion . https://doi.org/10.1111/trf.15973

Schmoll, D., Ziegler, N., Viollet, B., Foretz, M., Even, P.C., Azzout-Marniche, D., Nygaard Madsen, A., Illemann, M., Mandrup, K., Feigh, M., Czech, J., Glombik, H., Olsen, J.A., Hennerici, W., Steinmeyer, K., Elvert, R., Castañeda, T.R., Kannt, A.
Activation of Adenosine Monophosphate-Activated Protein Kinase Reduces the Onset of Diet-Induced Hepatocellular Carcinoma in Mice (2020) Hepatology communications, 4 (7), 1056–1072. https://doi.org/10.1002/hep4.1508

Schnetz, M., Meier, J.K., Rehwald, C., Mertens, C., Urbschat, A., Tomat, E., Akam, E.A., Baer, P., Roos, F.C., Brüne, B., Jung, M.
The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth (2020) Cancers, 12 (3). https://doi.org/10.3390/cancers12030530

Schnitzbauer, A.A., Kempf, V.A.J., Hack, D., Ciesek, S., Meier, S., Vehreschild, Maria J G T, Wicker, S., Kippke, U., Graf, J., Marzi, I.
SARS-CoV-2/COVID-19: systematic review of requirements for personal protective equipment in primary patient contact and organization of the operating area (2020) Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 91 (7), 576–585. https://doi.org/10.1007/s00104-020-01229-0

Scholz, A., Rappl, P., Böffinger, N., Mota, A.C., Brüne, B., Schmid, T.
Translation of TNFAIP2 is tightly controlled by upstream open reading frames (2020) Cellular and molecular life sciences : CMLS, 77 (10), 2017–2027. https://doi.org/10.1007/s00018-019-03265-4

Scholz, M.S., Wingen, L.M., Brunst, S., Wittmann, S.K., Cardoso, I.L.A., Weizel, L., Proschak, E.
Soluble epoxide hydrolase inhibitors with carboranes as non-natural 3-D pharmacophores (2020) European journal of medicinal chemistry, 185, 111766. https://doi.org/10.1016/j.ejmech.2019.111766

Schömel, N., Geisslinger, G., Wegner, M.-S.
Influence of glycosphingolipids on cancer cell energy metabolism (2020) Progress in lipid research, 79, 101050. https://doi.org/10.1016/j.plipres.2020.101050

Schömel, N., Gruber, L., Alexopoulos, S.J., Trautmann, S., Olzomer, E.M., Byrne, F.L., Hoehn, K.L., Gurke, R., Thomas, D., Ferreirós, N., Geisslinger, G., Wegner, M.-S.
UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells (2020) Scientific reports, 10 (1), 8182. https://doi.org/10.1038/s41598-020-65182-y

Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., Wenserski, L. von, Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D.G., Ciesek, S., Addo, M., Binder, M.
Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease (2020) Immunity, 53 (2), 442-455.e4. https://doi.org/10.1016/j.immuni.2020.06.024

Schuster, C., Huard, A., Sirait-Fischer, E., Dillmann, C., Brüne, B., Weigert, A.
S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model (2020) European journal of immunology, 50 (6), 839–845. https://doi.org/10.1002/eji.201948349

Sehnert, B., Burkhardt, H., Dübel, S., Voll, R.E.
Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases (2020) Cells, 9 (7). https://doi.org/10.3390/cells9071627

Sezin, T., Ferreirós, N., Jennrich, M., Ochirbold, K., Seutter, M., Attah, C., Mousavi, S., Zillikens, D., Geisslinger, G., Sadik, C.D.
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation (2020) Journal of autoimmunity, 115, 102528. https://doi.org/10.1016/j.jaut.2020.102528

Sipilä, R., Kalso, E., Lötsch, J.
Machine-learned identification of psychological subgroups with relation to pain interference in patients after breast cancer treatments (2020) Breast (Edinburgh, Scotland), 50, 71–80. https://doi.org/10.1016/j.breast.2020.01.042

Sirait-Fischer, E., Olesch, C., Fink, A.F., Berkefeld, M., Huard, A., Schmid, T., Takeda, K., Brüne, B., Weigert, A.
Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model (2020) Frontiers in oncology, 10, 1771. https://doi.org/10.3389/fonc.2020.01771

Sisignano, M., Steinhilber, D., Parnham, M.J., Geisslinger, G.
Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications (2020) Drug discovery today, 25 (9), 1744–1753. https://doi.org/10.1016/j.drudis.2020.07.002

Smelcerovic, A., Zivkovic, A., Ilic, B.S., Kolarevic, A., Hofmann, B., Steinhilber, D., Stark, H.
4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition (2020) Bioorganic chemistry, 95, 103528. https://doi.org/10.1016/j.bioorg.2019.103528

Snodgrass, R.G., Benatzy, Y., Schmid, T., Namgaladze, D., Mainka, M., Schebb, N.H., Lütjohann, D., Brüne, B.
Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation (2020) Cell death and differentiation . https://doi.org/10.1038/s41418-020-00652-4

Solbach, P., Chhatwal, P., Woltemate, S., Tacconelli, E., Buhl, M., Autenrieth, I.B., Vehreschild, M.J.G.T., Jazmati, N., Gerhard, M., Stein-Thoeringer, C.K., Rupp, J., Ulm, K., Ott, A., Lasch, F., Koch, A., Manns, M.P., Suerbaum, S., Bachmann, O.
Microbiota-associated risk factors for C. difficile acquisition in hospitalized patients: A prospective, multicentric study (2020) Clinical infectious diseases : an official publication of the Infectious Diseases Society of America . https://doi.org/10.1093/cid/ciaa871

Stallmach, A., Steube, A., Grunert, P., Hartmann, M., Biehl, L.M., Vehreschild, Maria J G T
Fecal Microbiota Transfer (2020) Deutsches Arzteblatt international, 117 (3), 31–38. https://doi.org/10.3238/arztebl.2020.0031

Stallmach, A., Sturm, A., Blumenstein, I., Helwig, U., Koletzko, S., Lynen, P., Schmidt, C., Dignaß, A., Kucharzik, T.
Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the COVID-19 Pandemic - open questions and answers (2020) Zeitschrift fur Gastroenterologie, 58 (7), 672–692. https://doi.org/10.1055/a-1193-5475

Stallmach, A., Sturm, A., Blumenstein, I., Helwig, U., Koletzko, S., Lynen, P., Schmidt, C., Dignaß, A., Kucharzik, T.
Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the COVID-19 Pandemic - open questions and answers (2020) Zeitschrift fur Gastroenterologie, 58 (7), e367. https://doi.org/10.1055/a-1375-6282

Stallmach, A., Sturm, A., Blumenstein, I., Helwig, U., Koletzko, S., Lynen, P., Schmidt, C., Dignass, A., Kucharzik, T.
Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the COVID-19 Pandemic - open questions and answers (2020) Zeitschrift fur Gastroenterologie, 58 (10), 982–1002. https://doi.org/10.1055/a-1234-8079

Stavniichuk, A., Hye Khan, M.A., Yeboah, M.M., Chesnik, M.A., Jankiewicz, W.K., Hartmann, M., Blöcher, R., Kircher, T., Savchuk, O., Proschak, E., Imig, J.D.
Dual soluble epoxide hydrolase inhibitor/PPAR-γ agonist attenuates renal fibrosis (2020) Prostaglandins & other lipid mediators, 150, 106472. https://doi.org/10.1016/j.prostaglandins.2020.106472

Strack, E., Rolfe, P.A., Fink, A.F., Bankov, K., Schmid, T., Solbach, C., Savai, R., Sha, W., Pradel, L., Hartmann, S., Brüne, B., Weigert, A.
Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis (2020) Clinical and translational medicine, 10 (8), e239. https://doi.org/10.1002/ctm2.239

Stratmann, J.A., Lacko, R., Ballo, O., Shaid, S., Gleiber, W., Vehreschild, M.J.G.T., Wichelhaus, T., Reinheimer, C., Göttig, S., Kempf, V.A.J., Kleine, P., Stera, S., Brandts, C., Sebastian, M., Koschade, S.
Colonization with multi-drug-resistant organisms negatively impacts survival in patients with non-small cell lung cancer (2020) PloS one, 15 (11), e0242544. https://doi.org/10.1371/journal.pone.0242544

Stürner, K.H., Werz, O., Koeberle, A., Otto, M., Pless, O., Leypoldt, F., Paul, F., Heesen, C.
Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis (2020) Scientific reports, 10 (1), 8776. https://doi.org/10.1038/s41598-020-65215-6

Syed, S.N., Brüne, B.
MicroRNAs as Emerging Regulators of Signaling in the Tumor Microenvironment (2020) Cancers, 12 (4). https://doi.org/10.3390/cancers12040911

Syed, S.N., Weigert, A., Brüne, B.
Sphingosine Kinases are Involved in Macrophage NLRP3 Inflammasome Transcriptional Induction (2020) International journal of molecular sciences, 21 (13). https://doi.org/10.3390/ijms21134733

Takeuchi, Y., Okinaka, Y., Ogawa, Y., Kikuchi-Taura, A., Kataoka, Y., Gul, S., Claussen, C., Boltze, J., Taguchi, A.
Intravenous Bone Marrow Mononuclear Cells Transplantation in Aged Mice Increases Transcription of Glucose Transporter 1 and Na(+)/K(+)-ATPase at Hippocampus Followed by Restored Neurological Functions (2020) Frontiers in aging neuroscience, 12, 170. https://doi.org/10.3389/fnagi.2020.00170

Tanoli, Z., Aldahdooh, J., Alam, F., Wang, Y., Seemab, U., Fratelli, M., Pavlis, P., Hajduch, M., Bietrix, F., Gribbon, P., Zaliani, A., Hall, M.D., Shen, M., Brimacombe, K., Kulesskiy, E., Saarela, J., Wennerberg, K., Vähä-Koskela, M., Tang, J.
Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments (2020) bioRxiv : the preprint server for biology . https://doi.org/10.1101/2020.12.03.409409

Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigurdsson, T., Hauser, M.J., Tenzer, S., Distler, U., Aoki, J., Morris, A.J., Geisslinger, G., Röper, J., Kirischuk, S., Luhmann, H.J., Radyushkin, K., Nitsch, R., Vogt, J.
Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (2020) Molecular psychiatry, 25 (11), 3108. https://doi.org/10.1038/s41380-018-0320-1

Toptan, T., Hoehl, S., Westhaus, S., Bojkova, D., Berger, A., Rotter, B., Hoffmeier, K., Cinatl, J., JR, Ciesek, S., Widera, M.
Optimized qRT-PCR Approach for the Detection of Intra- and Extra-Cellular SARS-CoV-2 RNAs (2020) International journal of molecular sciences, 21 (12). https://doi.org/10.3390/ijms21124396

Trümper, V., Wittig, I., Heidler, J., Richter, F., Brüne, B., Knethen, A. von
Redox Regulation of PPARγ in Polarized Macrophages (2020) PPAR research, 2020, 8253831. https://doi.org/10.1155/2020/8253831

Tsakmaklis, A., Vehreschild, M., Farowski, F., Trommer, M., Kohler, C., Herter, J., Marnitz, S.
Changes in the cervical microbiota of cervical cancer patients after primary radio-chemotherapy (2020) International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 30 (9), 1326–1330. https://doi.org/10.1136/ijgc-2019-000801

V - Z

van der Meer, A.-M., Berger, T., Müller, F., Foldenauer, A.C., Johnen, S., Walter, P.
Establishment and Characterization of a Unilateral UV-Induced Photoreceptor Degeneration Model in the C57Bl/6J Mouse (2020) Translational vision science & technology, 9 (9), 21. https://doi.org/10.1167/tvst.9.9.21

Vehreschild, M.J.G.T., Tsakmaklis, A., Nitschmann, S.
Intestinale Mikrobiota – Prädiktor für Mortalität nach Stammzelltransplantation (2020) Der Internist, 61 (9), 992–994. https://doi.org/10.1007/s00108-020-00819-8

Vehreschild, M.J.G.T., Tacconelli, E., Giske, C.G., Peschel, A.
Beyond COVID-19-a paradigm shift in infection management? (2020) The Lancet. Infectious diseases . https://doi.org/10.1016/S1473-3099(20)30789-1

Visser, M., van Oerle, R., Cate, H. ten, Laux, V., Mackman, N., Heitmeier, S., Spronk, H.M.H.
Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX (2020) Arteriosclerosis, thrombosis, and vascular biology, 40 (1), 103–111. https://doi.org/10.1161/ATVBAHA.119.313503

Vogel, A., Wilken-Schmitz, A., Hummel, R., Lang, M., Gurke, R., Schreiber, Y., Schäfer, M.K.E., Tegeder, I.
Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice (2020) Scientific reports, 10 (1), 14929. https://doi.org/10.1038/s41598-020-71879-x

Waidmann, O., Pleli, T., Weigert, A., Imelmann, E., Kakoschky, B., Schmithals, C., Döring, C., Frank, M., Longerich, T., Köberle, V., Hansmann, M.-L., Brüne, B., Zeuzem, S., Piiper, A., Dikic, I.
Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis (2020) Scientific reports, 10 (1), 16264. https://doi.org/10.1038/s41598-020-73387-4

Weber, S., Scheich, S., Magh, A., Wolf, S., Enßle, J.C., Brunnberg, U., Reinheimer, C., Wichelhaus, T.A., Kempf, V.A.J., Kessel, J., Vehreschild, M.J.G.T., Serve, H., Bug, G., Steffen, B., Hogardt, M.
Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation (2020) International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 99, 428–436. https://doi.org/10.1016/j.ijid.2020.08.030

Weiss, R., Loth, A., Guderian, D., Diensthuber, M., Kempf, V., Hack, D., Wicker, S., Ciesek, S., Graf, J., Stöver, T., Leinung, M.
Implementation of an operational concept in an ENT clinic in the context of the SARS-CoV-2 pandemic (2020) Laryngo- rhino- otologie, 99 (8), 552–560. https://doi.org/10.1055/a-1174-0234

Weiss, U., Möller, M., Husseini, S.A., Manderscheid, C., Häusler, J., Geisslinger, G., Niederberger, E.
Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade (2020) International journal of molecular sciences, 21 (23). https://doi.org/10.3390/ijms21238943

Wetzstein, N., Kohl, T.A., Andres, S., Schultze, T.G., Geil, A., Kim, E., Biciusca, T., Hügel, C., Hogardt, M., Lehn, A., Vehreschild, M.J.G.T., Wolf, T., Niemann, S., Maurer, F.P., Wichelhaus, T.A.
Comparative analysis of phenotypic and genotypic antibiotic susceptibility patterns in Mycobacterium avium complex (2020) International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 93, 320–328. https://doi.org/10.1016/j.ijid.2020.02.059

Wetzstein, N., Kohl, T.A., Schultze, T.G., Andres, S., Bellinghausen, C., Hügel, C., Kempf, V.A.J., Lehn, A., Hogardt, M., Serve, H., Vehreschild, M.J.G.T., Wolf, T., Niemann, S., Maurer, F.P., Wichelhaus, T.A.
Antimicrobial Susceptibility and Phylogenetic Relations in a German Cohort Infected with Mycobacterium abscessus (2020) Journal of clinical microbiology, 58 (12). https://doi.org/10.1128/JCM.01813-20

Wigington, C.P., Roy, J., Damle, N.P., Yadav, V.K., Blikstad, C., Resch, E., Wong, C.J., Mackay, D.R., Wang, J.T., Krystkowiak, I., Bradburn, D.A., Tsekitsidou, E., Hong, S.H., Kaderali, M.A., Xu, S.-L., Stearns, T., Gingras, A.-C., Ullman, K.S., Ivarsson, Y., Davey, N.E., Cyert, M.S.
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling (2020) Molecular cell, 79 (2), 342-358.e12. https://doi.org/10.1016/j.molcel.2020.06.029

Willems, S., Kilu, W., Ni, X., Chaikuad, A., Knapp, S., Heering, J., Merk, D.
The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs (2020) Communications Chemistry, 3 (1). https://doi.org/10.1038/s42004-020-0331-0

Witt, G., Keminer, O., Leu, J., Tandon, R., Meiser, I., Willing, A., Winschel, I., Abt, J.-C., Brändl, B., Sébastien, I., Friese, M.A., Müller, F.-J., Neubauer, J.C., Claussen, C., Zimmermann, H., Gribbon, P., Pless, O.
An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds (2020) Cell biology and toxicology . https://doi.org/10.1007/s10565-020-09538-0

Wolters, M.C., Schmetzer, J., Möser, C.V., Hahnefeld, L., Angioni, C., Thomas, D., Ferreirós, N., Geisslinger, G., Niederberger, E.
Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers (2020) Cells, 9 (9). https://doi.org/10.3390/cells9092111

Xanthopoulou, K., Peter, S., Tobys, D., Behnke, M., Dinkelacker, A.G., Eisenbeis, S., Falgenhauer, J., Falgenhauer, L., Fritzenwanker, M., Gölz, H., Häcker, G., Higgins, P.G., Imirzalioglu, C., Käding, N., Kern, W.V., Kramme, E., Kola, A., Mischnik, A., Rieg, S., Rohde, A.M., Rupp, J., Tacconelli, E., Vehreschild, M.J.G.T., Walker, S.V., Gastmeier, P., Seifert, H.
Vancomycin-resistant Enterococcus faecium colonizing patients on hospital admission in Germany: prevalence and molecular epidemiology (2020) The Journal of antimicrobial chemotherapy, 75 (10), 2743–2751. https://doi.org/10.1093/jac/dkaa271

Zavaritskaya, O., Dudem, S., Ma, D., Rabab, K.E., Albrecht, S., Tsvetkov, D., Kassmann, M., Thornbury, K., Mladenov, M., Kammermeier, C., Sergeant, G., Mullins, N., Wouappi, O., Wurm, H., Kannt, A., Gollasch, M., Hollywood, M.A., Schubert, R.
Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and K(v) 7 channels (2020) British journal of pharmacology, 177 (5), 1164–1186. https://doi.org/10.1111/bph.14910

Zhao, X.-Y., Wilmen, A., Wang, D., Wang, X., Bauzon, M., Kim, J.-Y., Linden, L., Li, L., Egner, U., Marquardt, T., Moosmayer, D., Tebbe, J., Glück, J.M., Ellinger, P., McLean, K., Yuan, S., Yegneswaran, S., Jiang, X., Evans, V., Gu, J.-M., Schneider, D., Zhu, Y., Xu, Y., Mallari, C., Hesslein, A., Wang, Y., Schmidt, N., Gutberlet, K., Ruehl-Fehlert, C., Freyberger, A., Hermiston, T., Patel, C., Sim, D., Mosnier, L.O., Laux, V.
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia (2020) Nature communications, 11 (1), 2992. https://doi.org/10.1038/s41467-020-16720-9

Ziegler, N., Bader, E., Epanchintsev, A., Margerie, D., Kannt, A., Schmoll, D.
AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification (2020) The Journal of biological chemistry, 295 (51), 17659–17671. https://doi.org/10.1074/jbc.RA120.0139

A - C

Annak, O., Heidegger, T., Walter, C., Deichmann, R., Nöth, U., Hansen-Goos, O., Ziemann, U., Lötsch, J.
Effects of continuous theta-burst stimulation of the primary motor and secondary somatosensory areas on the central processing and the perception of trigeminal nociceptive input in healthy volunteers (2019) Pain, 160 (1), 172–186. http://doi.org/10.1097/j.pain.0000000000001393

Astakhova, A., Chistyakov, D., Thomas, D., Geisslinger, G., Brüne, B., Sergeeva, M., Namgaladze, D.
Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization (2019) Cells, 8 (10). http://doi.org/10.3390/cells8101185

Bärnthaler, T., Jandl, K., Sill, H., Uhl, B., Schreiber, Y., Grill, M., Thomas, D., Schicho, R., Marsche, G., Frank, S., Heinemann, A., Schuligoi, R.
Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation (2019) The Journal of allergy and clinical immunology, 143 (2), 794-797.e10. http://doi.org/10.1016/j.jaci.2018.09.030

Bazarganipour, S., Hausmann, J., Oertel, S., El-Hindi, K., Brachtendorf, S., Blumenstein, I., Kubesch, A., Sprinzl, K., Birod, K., Hahnefeld, L., Trautmann, S., Thomas, D., Herrmann, E., Geisslinger, G., Schiffmann, S., Grösch, S.
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated (2019) Journal of clinical medicine, 8 (7). http://doi.org/10.3390/jcm8070971

Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Use of a "critical difference" statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis (2019) BMC rheumatology, 3, 51. http://doi.org/10.1186/s41927-019-0095-2

Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Wittig, B.M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis (2019) Scandinavian journal of rheumatology, 48 (5), 375–382. http://doi.org/10.1080/03009742.2019.1600717

Berben, P., Ashworth, L., Beato, S., Bevernage, J., Bruel, J.-L., Butler, J., Dressman, J.B., Schäfer, K., Hutchins, P., Klumpp, L., Mann, J., Nicolai, J., Ojala, K., Patel, S., Powell, S., Rosenblatt, K., Tomaszewska, I., Williams, J., Augustijns, P.
Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 140, 141–148. http://doi.org/10.1016/j.ejpb.2019.04.017

Bhaskara, R.M., Grumati, P., Garcia-Pardo, J., Kalayil, S., Covarrubias-Pinto, A., Chen, W., Kudryashev, M., Dikic, I., Hummer, G.
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy (2019) Nature communications, 10 (1), 2370. http://doi.org/10.1038/s41467-019-10345-3

Bhogaraju, S., Bonn, F., Mukherjee, R., Adams, M., Pfleiderer, M.M., Galej, W.P., Matkovic, V., Lopez-Mosqueda, J., Kalayil, S., Shin, D., Dikic, I.
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation (2019) Nature, 572 (7769), 382–386. http://doi.org/10.1038/s41586-019-1440-8

Bode, E., Heinrich, A.K., Hirschmann, M., Abebew, D., Shi, Y.-N., Vo, T.D., Wesche, F., Shi, Y.-M., Grün, P., Simonyi, S., Keller, N., Engel, Y., Wenski, S., Bennet, R., Beyer, S., Bischoff, I., Buaya, A., Brandt, S., Cakmak, I., Çimen, H., Eckstein, S., Frank, D., Fürst, R., Gand, M., Geisslinger, G., Hazir, S., Henke, M., Heermann, R., Lecaudey, V., Schäfer, W., Schiffmann, S., Schüffler, A., Schwenk, R., Skaljac, M., Thines, E., Thines, M., Ulshöfer, T., Vilcinskas, A., Wichelhaus, T.A., Bode, H.B.
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (2019) Angewandte Chemie (International ed. in English), 58 (52), 18957–18963. http://doi.org/10.1002/anie.201910563

Borsari, C., Jiménez-Antón, M.D., Eick, J., Bifeld, E., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Santarem, N., Baptista, C., Severi, L., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Linciano, P., Tait, A., Costantino, L., Luciani, R., Tejera Nevado, P., Zander-Dinse, D., Franco, C.H., Ferrari, S., Moraes, C.B., Cordeiro-da-Silva, A., Ponterini, G., Clos, J., Alunda, J.M., Costi, M.P.
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics (2019) European journal of medicinal chemistry, 183, 111676. http://doi.org/10.1016/j.ejmech.2019.111676

Borsari, C., Santarem, N., Macedo, S., Jiménez-Antón, M.D., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Tait, A., Ferrari, S., Costantino, L., Luciani, R., Ponterini, G., Gul, S., Kuzikov, M., Ellinger, B., Behrens, B., Reinshagen, J., Alunda, J.M., Cordeiro-da-Silva, A., Costi, M.P.
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent (2019) ACS medicinal chemistry letters, 10 (4), 528–533. http://doi.org/10.1021/acsmedchemlett.8b00565

Braun, J., Schwarting, A., Hammel, L., Legeler, C., Wimmer, P., Färber, L., Behrens, F.
Versorgungssituation von Patienten mit ankylosierender Spondylitis und Psoriasisarthritis in Deutschland : Versorgungssituation von Patienten mit Spondyloarthritis (SpA): Ankylosierende Spondylitis (AS) und Psoriasisarthritis (PsA) aus der Sicht von niedergelassenen und in Kliniken tätigen Rheumatologen in Deutschland – Ergebnisse des Forschungsprojekts „SpA Loop – Life of Outpatients“ (2019) Zeitschrift fur Rheumatologie, 78 (4), 372–381. http://doi.org/10.1007/s00393-019-0619-6

Brennecke, P., Rasina, D., Aubi, O., Herzog, K., Landskron, J., Cautain, B., Vicente, F., Quintana, J., Mestres, J., Stechmann, B., Ellinger, B., Brea, J., Kolanowski, J.L., Pilarski, R., Orzaez, M., Pineda-Lucena, A., Laraia, L., Nami, F., Zielenkiewicz, P., Paruch, K., Hansen, E., Kries, J.P. von, Neuenschwander, M., Specker, E., Bartunek, P., Simova, S., Leśnikowski, Z., Krauss, S., Lehtiö, L., Bilitewski, U., Brönstrup, M., Taskén, K., Jirgensons, A., Lickert, H., Clausen, M.H., Andersen, J.H., Vicent, M.J., Genilloud, O., Martinez, A., Nazaré, M., Fecke, W., Gribbon, P.
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology (2019) SLAS discovery : advancing life sciences R & D, 24 (3), 398–413. http://doi.org/10.1177/2472555218816276

Brunkhorst-Kanaan, N., Klatt-Schreiner, K., Hackel, J., Schröter, K., Trautmann, S., Hahnefeld, L., Wicker, S., Reif, A., Thomas, D., Geisslinger, G., Kittel-Schneider, S., Tegeder, I.
Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder (2019) Metabolism: clinical and experimental, 95, 65–76. http://doi.org/10.1016/j.metabol.2019.04.002

Chen, C., Kramer, J.S., Brunst, S., Proschak, E., Scriba, G.K.E.
Capillary electrophoresis-based enzyme assays for β-lactamase enzymes (2019) Electrophoresis, 40 (18-19), 2375–2381. http://doi.org/10.1002/elps.201900104

Choy, E., Baraliakos, X., Behrens, F., D'Angelo, S., Vlam, K. de, Kirkham, B.W., Østergaard, M., Schett, G.A., Rissler, M., Chaouche-Teyara, K., Perella, C.
The need for comparative data in spondyloarthritis (2019) Arthritis research & therapy, 21 (1), 32. http://doi.org/10.1186/s13075-019-1812-3

Cristofoletti, R., Hens, B., Patel, N., Esteban, V.V., Schmidt, S., Dressman, J.B.
Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen (2019) Journal of pharmaceutical sciences, 108 (12), 3842–3847. http://doi.org/10.1016/j.xphs.2019.09.012

D – F

Dauth, S., Köhm, M., Behrens, F.
Psoriatic arthritis: combinational therapy of biologics and methotrexate - What do we know? (2019) Clinical Trials in Degenerative Diseases, 4 (4), 0. http://doi.org/10.4103/2542-3975.274078

Deutschmann, J., Schneider, A., Gruska, I., Vetter, B., Thomas, D., Kießling, M., Wittmann, S., Herrmann, A., Schindler, M., Milbradt, J., Ferreirós, N., Winkler, T.H., Wiebusch, L., Gramberg, T.
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1 (2019) Nature microbiology, 4 (12), 2273–2284. http://doi.org/10.1038/s41564-019-0529-z

Ditzinger, F., Price, D.J., Nair, A., Becker-Baldus, J., Glaubitz, C., Dressman, J.B., Saal, C., Kuentz, M.
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies (2019) Pharmaceutics, 11 (11). http://doi.org/10.3390/pharmaceutics11110577

Dreis, C., Ottenlinger, F.M., Putyrski, M., Ernst, A., Huhn, M., Schmidt, K.G., Pfeilschifter, J.M., Radeke, H.H.
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs (2019) Frontiers in immunology, 10, 1698. http://doi.org/10.3389/fimmu.2019.01698

Dufrusine, B., Di Francesco, A., Oddi, S., Scipioni, L., Angelucci, C.B., D'Addario, C., Serafini, M., Häfner, A.-K., Steinhilber, D., Maccarrone, M., Dainese, E.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation (2019) Frontiers in immunology, 10, 1347. http://doi.org/10.3389/fimmu.2019.01347

Ehrnhoefer, D.E., Skotte, N.H., Reinshagen, J., Qiu, X., Windshügel, B., Jaishankar, P., Ladha, S., Petina, O., Khankischpur, M., Nguyen, Y.T.N., Caron, N.S., Razeto, A., Meyer Zu Rheda, M., Deng, Y., Huynh, K.T., Wittig, I., Gribbon, P., Renslo, A.R., Geffken, D., Gul, S., Hayden, M.R.
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound (2019) Cell chemical biology, 26 (9), 1295-1305.e6. http://doi.org/10.1016/j.chembiol.2019.07.001

Elwakeel, E., Brüggemann, M., Fink, A.F., Schulz, M.H., Schmid, T., Savai, R., Brüne, B., Zarnack, K., Weigert, A.
Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development (2019) International journal of molecular sciences, 20 (18). http://doi.org/10.3390/ijms20184438

Elzahhar, P.A., Alaaeddine, R., Ibrahim, T.M., Nassra, R., Ismail, A., Chua, B.S.K., Frkic, R.L., Bruning, J.B., Wallner, N., Knape, T., von Knethen, A., Labib, H., El-Yazbi, A.F., Belal, A.S.F.
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones (2019) European journal of medicinal chemistry, 167, 562–582. http://doi.org/10.1016/j.ejmech.2019.02.034

Englbrecht, M., Alten, R., Aringer, M., Baerwald, C.G., Burkhardt, H., Eby, N., Flacke, J.-P., Fliedner, G., Henkemeier, U., Hofmann, M.W., Kleinert, S., Kneitz, C., Krüger, K., Pohl, C., Schett, G.A., Schmalzing, M., Tausche, A.-K., Tony, H.-P., Wendler, J.
New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis - Implications from the prospective multicenter VADERA II study (2019) PloS one, 14 (5), e0217412. http://doi.org/10.1371/journal.pone.0217412

Feczkó, T., Piiper, A., Ansar, S., Blixt, F.W., Ashtikar, M., Schiffmann, S., Ulshöfer, T., Parnham, M.J., Harel, Y., Israel, L.L., Lellouche, J.-P., Wacker, M.G.
Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy (2019) Journal of controlled release : official journal of the Controlled Release Society, 293, 63–72. http://doi.org/10.1016/j.jconrel.2018.11.017

Fettel, J., Kühn, B., Guillen, N.A., Sürün, D., Peters, M., Bauer, R., Angioni, C., Geisslinger, G., Schnütgen, F., Meyer Zu Heringdorf, D., Werz, O., Meybohm, P., Zacharowski, K., Steinhilber, D., Roos, J., Maier, T.J.
Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (2), 1711–1726. http://doi.org/10.1096/fj.201800221R

Fuhrmann, D.C., Olesch, C., Kurrle, N., Schnütgen, F., Zukunft, S., Fleming, I., Brüne, B.
Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins (2019) Cells, 8 (2). http://doi.org/10.3390/cells8020172

G – I

Göbel, T., Diehl, O., Heering, J., Merk, D., Angioni, C., Wittmann, S.K., La Buscato, E., Kottke, R., Weizel, L., Schader, T., Maier, T.J., Geisslinger, G., Schubert-Zsilavecz, M., Steinhilber, D., Proschak, E., Kahnt, A.S.
Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ (2019) Frontiers in pharmacology, 10, 263. http://doi.org/10.3389/fphar.2019.00263

Grill, M., Högenauer, C., Blesl, A., Haybaeck, J., Golob-Schwarzl, N., Ferreirós, N., Thomas, D., Gurke, R., Trötzmüller, M., Köfeler, H.C., Gallé, B., Schicho, R.
Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer (2019) Scientific reports, 9 (1), 2358. http://doi.org/10.1038/s41598-019-38865-4

Gul, S.
Key concepts in assay development, screening and the properties of lead and candidate compounds (2019) In Medicinal Chemistry of Neglected and Tropical Diseases, 1-18. CRC Press. http://doi.org/10.1201/9781351011655

Gurke, R., Etyemez, S., Prvulovic, D., Thomas, D., Fleck, S.C., Reif, A., Geisslinger, G., Lötsch, J.
A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia (2019) Frontiers in psychiatry, 10, 41. http://doi.org/10.3389/fpsyt.2019.00041

Gurke, R., Schmidt, D., Thomas, D., Fleck, S.C., Geisslinger, G., Ferreirós, N.
A validated LC-MS/MS method for the determination of homocysteic acid in biological samples (2019) Journal of pharmaceutical and biomedical analysis, 174, 578–587. http://doi.org/10.1016/j.jpba.2019.06.008

Gurke, R., Thomas, D., Schreiber, Y., Schäfer, S.M.G., Fleck, S.C., Geisslinger, G., Ferreirós, N.
Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics (2019) Talanta, 204, 386–394. http://doi.org/10.1016/j.talanta.2019.06.004

Häfner, A.-K., Kahnt, A.S., Steinhilber, D.
Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase (2019) Prostaglandins & other lipid mediators, 142, 24–32. http://doi.org/10.1016/j.prostaglandins.2019.03.003

Han, Y., Mora, J., Huard, A., da Silva, P., Wiechmann, S., Putyrski, M., Schuster, C., Elwakeel, E., Lang, G., Scholz, A., Scholz, T., Schmid, T., de Bruin, N., Billuart, P., Sala, C., Burkhardt, H., Parnham, M.J., Ernst, A., Brüne, B., Weigert, A.
IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells (2019) Cell reports, 27 (3), 835-846.e5. http://doi.org/10.1016/j.celrep.2019.03.082

Harder, S., Meyer Dos Santos, S., Krozer, V., Moll, J.
Surface Acoustic Wave-Based Microfluidic Coagulation Device for Monitoring Anticoagulant Therapy (2019) Seminars in thrombosis and hemostasis, 45 (3), 253–258. http://doi.org/10.1055/s-0038-1676318

Hardt, S., Fischer, C., Vogel, A., Wilken-Schmitz, A., Tegeder, I.
Distal infraorbital nerve injury: a model for persistent facial pain in mice (2019) Pain, 160 (6), 1431–1447. http://doi.org/10.1097/j.pain.0000000000001518

Heering, J., Merk, D.
Hybrid Reporter Gene Assays: Versatile In Vitro Tools to Characterize Nuclear Receptor Modulators (2019) Methods in molecular biology (Clifton, N.J.), 1966, 175–192. http://doi.org/10.1007/978-1-4939-9195-2_14

Heine, P., Witt, G., Gilardi, A., Gribbon, P., Kummer, L., Plückthun, A.
High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor (2019) SLAS discovery : advancing life sciences R & D, 24 (9), 915–927. http://doi.org/10.1177/2472555219837344

Heitel, P., Gellrich, L., Kalinowsky, L., Heering, J., Kaiser, A., Ohrndorf, J., Proschak, E., Merk, D.
Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype (2019) ACS medicinal chemistry letters, 10 (2), 203–208. http://doi.org/10.1021/acsmedchemlett.8b00551

Hernández-Olmos, V., Knape, T., Heering, J., von Knethen, A., Kilu, W., Kaiser, A., Wurglics, M., Helmstädter, M., Merk, D., Schubert-Zsilavecz, M., Parnham, M.J., Steinhilber, D., Proschak, E.
Structure optimization of a new class of PPARγ antagonists (2019) Bioorganic & medicinal chemistry, 27 (21), 115082. http://doi.org/10.1016/j.bmc.2019.115082

Hiesinger, K., Kramer, J.S., Achenbach, J., Moser, D., Weber, J., Wittmann, S.K., Morisseau, C., Angioni, C., Geisslinger, G., Kahnt, A.S., Kaiser, A., Proschak, A., Steinhilber, D., Pogoryelov, D., Wagner, K.M., Hammock, B.D., Proschak, E.
Computer-Aided Selective Optimization of Side Activities of Talinolol (2019) ACS medicinal chemistry letters, 10 (6), 899–903. http://doi.org/10.1021/acsmedchemlett.9b00075

Hiesinger, K., Wagner, K.M., Hammock, B.D., Proschak, E., Hwang, S.H.
Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity (2019) Prostaglandins & other lipid mediators, 140, 31–39. http://doi.org/10.1016/j.prostaglandins.2018.12.003

Hübner, C.A., Dikic, I.
ER-phagy and human diseases (2019) Cell death and differentiation . http://doi.org/10.1038/s41418-019-0444-0

J – L

Jablonka, L., Ashtikar, M., Gao, G.F., Jung, F., Thurn, M., Preuß, A., Scheglmann, D., Albrecht, V., Röder, B., Wacker, M.G.
Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans (2019) Journal of controlled release : official journal of the Controlled Release Society, 308, 57–70. http://doi.org/10.1016/j.jconrel.2019.06.029

Janczi, T., Böhm, B.B., Fehrl, Y., DeGiacomo, P., Kinne, R.W., Burkhardt, H.
ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment (2019) Arthritis & rheumatology (Hoboken, N.J.), 71 (1), 63–72. http://doi.org/10.1002/art.40667

Jung, M., Mertens, C., Tomat, E., Brüne, B.
Iron as a Central Player and Promising Target in Cancer Progression (2019) International journal of molecular sciences, 20 (2). http://doi.org/10.3390/ijms20020273

Juretschke, T., Beli, P., Dikic, I.
Quantitative Phosphoproteomics of Selective Autophagy Receptors (2019) Methods in molecular biology (Clifton, N.J.), 1880, 691–701. http://doi.org/10.1007/978-1-4939-8873-0_46

Kambayashi, A., Dressman, J.B.
A novel in vivo predictive dissolution testing coupled with a modeling and simulation for hydrogel matrix monolithic extended release oral dosage forms (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 138, 105044. http://doi.org/10.1016/j.ejps.2019.105044

Kambayashi, A., Dressman, J.B.
Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir (2019) Journal of pharmaceutical sciences, 108 (1), 584–591. http://doi.org/10.1016/j.xphs.2018.11.008

Kambayashi, A., Kiyota, T., Fujiwara, M., Dressman, J.B.
PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 135, 83–90. http://doi.org/10.1016/j.ejps.2019.05.013

Keminer, O., Teigeler, M., Kohler, M., Wenzel, A., Arning, J., Kaßner, F., Windshügel, B., Eilebrecht, E.
A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes (2019) The Science of the total environment, 134743. http://doi.org/10.1016/j.scitotenv.2019.134743

Keminer, O., Windshügel, B., Essmann, F., Lee, S.M.L., Schiergens, T.S., Schwab, M., Burk, O.
Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3 (2019) Archives of toxicology, 93 (8), 2247–2264. http://doi.org/10.1007/s00204-019-02495-6

Klumpp, L., Nagasekar, K., McCullough, O., Seybert, A., Ashtikar, M., Dressman, J.B.
Stability of Biorelevant Media Under Various Storage Conditions (2019) Dissolution Technologies, 26 (2), 6–18. http://doi.org/10.14227/DT260219P6

Köhm, M., Behrens, F.
Aktuelle Therapie der Psoriasisarthritis (2019) Aktuelle Rheumatologie, 44 (05), 339–344. http://doi.org/10.1055/a-1004-3274

Köhm, M., Behrens, F.
Therapie der Psoriasisarthritis: Gibt es eine Differenzialindikation? (2019) Zeitschrift fur Rheumatologie. http://doi.org/10.1007/s00393-019-00709-x

König, S., Pace, S., Pein, H., Heinekamp, T., Kramer, J.S., Romp, E., Straßburger, M., Troisi, F., Proschak, A., Dworschak, J., Scherlach, K., Rossi, A., Sautebin, L., Haeggström, J.Z., Hertweck, C., Brakhage, A.A., Gerstmeier, J., Proschak, E., Werz, O.
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase (2019) Cell chemical biology, 26 (4), 524-534.e5. http://doi.org/10.1016/j.chembiol.2019.01.001

König, S., Romp, E., Krauth, V., Rühl, M., Dörfer, M., Liening, S., Hofmann, B., Häfner, A.-K., Steinhilber, D., Karas, M., Garscha, U., Hoffmeister, D., Werz, O.
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159 (2019) Cell chemical biology, 26 (1), 60-70.e4. http://doi.org/10.1016/j.chembiol.2018.10.010

Kramer, J.S., Woltersdorf, S., Duflot, T., Hiesinger, K., Lillich, F.F., Knöll, F., Wittmann, S.K., Klingler, F.-M., Brunst, S., Chaikuad, A., Morisseau, C., Hammock, B.D., Buccellati, C., Sala, A., Rovati, G.E., Leuillier, M., Fraineau, S., Rondeaux, J., Hernández-Olmos, V., Heering, J., Merk, D., Pogoryelov, D., Steinhilber, D., Knapp, S., Bellien, J., Proschak, E.
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain (2019) Journal of medicinal chemistry, 62 (18), 8443–8460. http://doi.org/10.1021/acs.jmedchem.9b00445

Kringel, D., Kaunisto, M.A., Kalso, E., Lötsch, J.
Machine-learned analysis of global and glial/opioid intersection-related DNA methylation in patients with persistent pain after breast cancer surgery (2019) Clinical epigenetics, 11 (1), 167. http://doi.org/10.1186/s13148-019-0772-4

Kringel, D., Kaunisto, M.A., Kalso, E., Lötsch, J.
Machine-learned analysis of the association of next-generation sequencing-based genotypes with persistent pain after breast cancer surgery (2019) Pain, 160 (10), 2263–2277. http://doi.org/10.1097/j.pain.0000000000001616

Kuhnert, R., Sárosi, M.-B., George, S., Lönnecke, P., Hofmann, B., Steinhilber, D., Steinmann, S., Schneider-Stock, R., Murganić, B., Mijatović, S., Maksimović-Ivanić, D., Hey-Hawkins, E.
Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells (2019) ChemMedChem, 14 (2), 255–261. http://doi.org/10.1002/cmdc.201800651

Kurz, J., Barthelmes, J., Blum, L., Ulshöfer, T., Wegner, M.-S., Ferreirós, N., Roser, L., Geisslinger, G., Grösch, S., Schiffmann, S.
Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes (2019) Scientific reports, 9 (1), 747. http://doi.org/10.1038/s41598-018-37342-8

Kurz, J., Parnham, M.J., Geisslinger, G., Schiffmann, S.
Ceramides as Novel Disease Biomarkers (2019) Trends in molecular medicine, 25 (1), 20–32. http://doi.org/10.1016/j.molmed.2018.10.009

Landi, G., Linciano, P., Borsari, C., Bertolacini, C.P., Moraes, C.B., Cordeiro-da-Silva, A., Gul, S., Witt, G., Kuzikov, M., Costi, M.P., Pozzi, C., Mangani, S.
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors (2019) ACS infectious diseases, 5 (7), 1105–1114. http://doi.org/10.1021/acsinfecdis.8b00358

Lim, R., Sugino, T., Nolte, H., Andrade, J., Zimmermann, B., Shi, C., Doddaballapur, A., Ong, Y.T., Wilhelm, K., Fasse, J.W.D., Ernst, A., Kaulich, M., Husnjak, K., Boettger, T., Guenther, S., Braun, T., Krüger, M., Benedito, R., Dikic, I., Potente, M.
Deubiquitinase USP10 regulates Notch signaling in the endothelium (2019) Science (New York, N.Y.), 364 (6436), 188–193. http://doi.org/10.1126/science.aat0778

Linciano, P., Pozzi, C., Iacono, L.D., Di Pisa, F., Landi, G., Bonucci, A., Gul, S., Kuzikov, M., Ellinger, B., Witt, G., Santarem, N., Baptista, C., Franco, C., Moraes, C.B., Müller, W., Wittig, U., Luciani, R., Sesenna, A., Quotadamo, A., Ferrari, S., Pöhner, I., Cordeiro-da-Silva, A., Mangani, S., Costantino, L., Costi, M.P.
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections (2019) Journal of medicinal chemistry, 62 (8), 3989–4012. http://doi.org/10.1021/acs.jmedchem.8b02021

Linke, B., Meyer Dos Santos, S., Picard-Willems, B., Keese, M., Harder, S., Geisslinger, G., Scholich, K.
CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium (2019) Cytokine, 122, 154081. http://doi.org/10.1016/j.cyto.2017.06.008

Lippmann, C., Ultsch, A., Lötsch, J.
Computational functional genomics-based reduction of disease-related gene sets to their key components (2019) Bioinformatics (Oxford, England), 35 (14), 2362–2370. http://doi.org/10.1093/bioinformatics/bty986

Litou, C., Patel, N., Turner, D.B., Kostewicz, E., Kuentz, M., Box, K.J., Dressman, J.B.
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 138, 105031. http://doi.org/10.1016/j.ejps.2019.105031

Löhr, S., Ekici, A.B., Uebe, S., Büttner, C., Köhm, M., Behrens, F., Böhm, B.B., Sticherling, M., Schett, G.A., Simon, D., Mössner, R., Nimeh, A., Oji, V., Assmann, G., Rech, J., Holmdahl, R., Burkhardt, H., Reis, A., Hüffmeier, U.
Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants (2019) Rheumatology (Oxford, England), 58 (5), 915–917. http://doi.org/10.1093/rheumatology/key448

Loisios-Konstantinidis, I., Paraiso, R.L.M., Fotaki, N., McAllister, M., Cristofoletti, R., Dressman, J.
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review (2019) The Journal of pharmacy and pharmacology, 71 (4), 699–723. http://doi.org/10.1111/jphp.13070

Lötsch, J., Geisslinger, G., Walter, C.
Wissensgenerierung aus komplexen Datensätzen in der humanexperimentellen Schmerzforschung (2019) Schmerz (Berlin, Germany), 33 (6), 502–513. http://doi.org/10.1007/s00482-019-00412-5

Lötsch, J., Haehner, A., Hummel, T.
Machine-learning-derived rules set excludes risk of Parkinson's disease in patients with olfactory or gustatory symptoms with high accuracy (2019) Journal of neurology. http://doi.org/10.1007/s00415-019-09604-6

Lötsch, J., Hummel, T.
A data science-based analysis of seasonal patterns in outpatient presentations due to olfactory dysfunction (2019) Rhinology. http://doi.org/10.4193/Rhin19.099

Lötsch, J., Hummel, T.
A machine-learned analysis suggests non-redundant diagnostic information in olfactory subtests (2019) IBRO reports, 6, 64–73. http://doi.org/10.1016/j.ibror.2019.01.002

Lötsch, J., Hummel, T.
Clinical Usefulness of Self-Rated Olfactory Performance-A Data Science-Based Assessment of 6000 Patients (2019) Chemical senses, 44 (6), 357–364. http://doi.org/10.1093/chemse/bjz029

Lötsch, J., Hummel, T.
Machine-learned analysis of side-differences in odor identification performance (2019) Neuroscience, 422, 44–53. http://doi.org/10.1016/j.neuroscience.2019.09.033

Lötsch, J., Kringel, D., Hummel, T.
Machine Learning in Human Olfactory Research (2019) Chemical senses, 44 (1), 11–22. http://doi.org/10.1093/chemse/bjy067

Lötsch, J., Ultsch, A.
Current Projection Methods-Induced Biases at Subgroup Detection for Machine-Learning Based Data-Analysis of Biomedical Data (2019) International journal of molecular sciences, 21 (1). http://doi.org/10.3390/ijms21010079

Lötsch, J., Walter, C., Zunftmeister, M., Zinn, S., Wolters, M., Ferreirós, N., Rossmanith, T., Oertel, B.G., Geisslinger, G.
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects (2019) Basic & clinical pharmacology & toxicology. http://doi.org/10.1111/bcpt.13337

M – O

Maric, J., Ravindran, A., Mazzurana, L., van Acker, A., Rao, A., Kokkinou, E., Ekoff, M., Thomas, D., Fauland, A., Nilsson, G., Wheelock, C.E., Dahlén, S.-E., Ferreirós, N., Geisslinger, G., Friberg, D., Heinemann, A., Konya, V., Mjösberg, J.
Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation (2019) The Journal of allergy and clinical immunology, 143 (6), 2202-2214.e5. http://doi.org/10.1016/j.jaci.2018.10.069

Marques, M.R.C., Choo, Q., Ashtikar, M., Rocha, T.C., Bremer-Hoffmann, S., Wacker, M.G.
Nanomedicines - Tiny particles and big challenges (2019) Advanced drug delivery reviews, 151-152, 23–43. http://doi.org/10.1016/j.addr.2019.06.003

Martin, L.M., Möller, M., Weiss, U., Russe, O.Q., Scholich, K., Pierre, S., Geisslinger, G., Niederberger, E.
5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift (2019) International journal of molecular sciences, 20 (13). http://doi.org/10.3390/ijms20133255

Misra, M., Dikic, I.
RNA binding to p62 impacts selective autophagy (2019) Cell research, 29 (7), 512–513. http://doi.org/10.1038/s41422-019-0167-2

Mojtahed Poor, S., Ulshöfer, T., Gabriel, L.A., Henke, M., Köhm, M., Behrens, F., Geisslinger, G., Parnham, M.J., Burkhardt, H., Schiffmann, S.
Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab (2019) Clinical and experimental immunology, 196 (2), 259–275. http://doi.org/10.1111/cei.13261

Mora, J., Mertens, C., Meier, J.K., Fuhrmann, D.C., Brüne, B., Jung, M.
Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity (2019) Cells, 8 (5). http://doi.org/10.3390/cells8050445

Moraes, C.B., Witt, G., Kuzikov, M., Ellinger, B., Calogeropoulou, T., Prousis, K.C., Mangani, S., Di Pisa, F., Landi, G., Iacono, L.D., Pozzi, C., Freitas-Junior, L.H., Dos Santos Pascoalino, B., Bertolacini, C.P., Behrens, B., Keminer, O., Leu, J., Wolf, M., Reinshagen, J., Cordeiro-da-Silva, A., Santarem, N., Venturelli, A., Wrigley, S., Karunakaran, D., Kebede, B., Pöhner, I., Müller, W., Panecka-Hofman, J., Wade, R.C., Fenske, M., Clos, J., Alunda, J.M., Corral, M.J., Uliassi, E., Bolognesi, M.L., Linciano, P., Quotadamo, A., Ferrari, S., Santucci, M., Borsari, C., Costi, M.P., Gul, S.
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform (2019) SLAS discovery : advancing life sciences R & D, 24 (3), 346–361. http://doi.org/10.1177/2472555218823171

Moreno-Cinos, C., Sassetti, E., Salado, I.G., Witt, G., Benramdane, S., Reinhardt, L., Cruz, C.D., Joossens, J., van der Veken, P., Brötz-Oesterhelt, H., Tammela, P., Winterhalter, M., Gribbon, P., Windshügel, B., Augustyns, K.
α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease (2019) Journal of medicinal chemistry, 62 (2), 774–797. http://doi.org/10.1021/acs.jmedchem.8b01466

Möser, C.V., Möller, M., Fleck, S.C., Thomas, D., Geisslinger, G., Niederberger, E.
Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice (2019) Neuropharmacology, 146, 198–211. http://doi.org/10.1016/j.neuropharm.2018.12.004

Mukherjee, R., Dikic, I.
NIPSNAP Beacons in Mitophagy (2019) Developmental cell, 49 (4), 503–505. http://doi.org/10.1016/j.devcel.2019.05.008

Namgaladze, D., Khodzhaeva, V., Brüne, B.
ER-Mitochondria Communication in Cells of the Innate Immune System (2019) Cells, 8 (9). http://doi.org/10.3390/cells8091088

Nguyen, T.D., Shaid, S., Vakhrusheva, O., Koschade, S.E., Klann, K., Thölken, M., Baker, F., Zhang, J., Oellerich, T., Sürün, D., Derlet, A., Haberbosch, I., Eimer, S., Osiewacz, H.D., Behrends, C., Münch, C., Dikic, I., Brandts, C.H.
Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy (2019) Blood, 133 (2), 168–179. http://doi.org/10.1182/blood-2018-02-833475

Niederberger, E., Parnham, M.J., Maas, J., Geisslinger, G.
4 Ds in health research-working together toward rapid precision medicine (2019) EMBO molecular medicine, 11 (11), e10917. http://doi.org/10.15252/emmm.201910917

Nothnagel, L., Jung, F., Rossmanith, T., Thurn, M., Ashtikar, M., Geisslinger, G., Parnham, M.J., Wacker, M.G.
Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001 (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 144–152. http://doi.org/10.1016/j.ejpb.2018.11.012

O'Dwyer, P.J., Litou, C., Box, K.J., Dressman, J.B., Kostewicz, E.S., Kuentz, M., Reppas, C.
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review (2019) The Journal of pharmacy and pharmacology, 71 (4), 536–556. http://doi.org/10.1111/jphp.12951

Oellerich, T., Schneider, C., Thomas, D., Knecht, K.M., Buzovetsky, O., Kaderali, L., Schliemann, C., Bohnenberger, H., Angenendt, L., Hartmann, W., Wardelmann, E., Rothenburger, T., Mohr, S., Scheich, S., Comoglio, F., Wilke, A., Ströbel, P., Serve, H., Michaelis, M., Ferreirós, N., Geisslinger, G., Xiong, Y., Keppler, O.T., Cinatl, J.
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML (2019) Nature communications, 10 (1), 3475. http://doi.org/10.1038/s41467-019-11413-4

Okinaka, Y., Kikuchi-Taura, A., Takeuchi, Y., Ogawa, Y., Boltze, J., Gul, S., Claussen, C., Taguchi, A.
Clot-Derived Contaminants in Transplanted Bone Marrow Mononuclear Cells Impair the Therapeutic Effect in Stroke (2019) Stroke, 50 (10), 2883–2891. http://doi.org/10.1161/STROKEAHA.119.026669

Ortmann, C.A., Dorsheimer, L., Abou-El-Ardat, K., Hoffrichter, J., Assmus, B., Bonig, H., Scholz, A., Pfeifer, H., Martin, H., Schmid, T., Brüne, B., Scheich, S., Steffen, B., Riemann, J., Hermann, S., Dukat, A., Bug, G., Brandts, C.H., Wagner, S., Serve, H., Rieger, M.A.
Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation (2019) Cell reports, 27 (7), 2022-2028.e3. http://doi.org/10.1016/j.celrep.2019.04.064

Osthues, T., Sisignano, M.
Oxidized Lipids in Persistent Pain States (2019) Frontiers in pharmacology, 10, 1147. http://doi.org/10.3389/fphar.2019.01147

P – R

Paraiso, R.L.M., Watanabe, A., Andreas, C.J., Turner, D.B., Zane, P., Dressman, J.B.
In-vitro-in-silico investigation of the negative food effect of zolpidem when administered as immediate-release tablets (2019) The Journal of pharmacy and pharmacology, 71 (11), 1663–1676. http://doi.org/10.1111/jphp.13161

Parnham, M.J., Geisslinger, G.
Pharmacological plasticity-How do you hit a moving target? (2019) Pharmacology research & perspectives, 7 (6), e00532. http://doi.org/10.1002/prp2.532

Parnham, M.J., Nijkamp, F.P., Rossi, A.G.
Nijkamp and Parnham's Principles of Immunopharmacology (2019). Springer International Publishing. http://doi.org/10.1007/978-3-030-10811-3

Pentafragka, C., Symillides, M., McAllister, M., Dressman, J.B., Vertzoni, M., Reppas, C.
The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review (2019) The Journal of pharmacy and pharmacology, 71 (4), 557–580. http://doi.org/10.1111/jphp.12999

Pohl, C., Dikic, I.
Cellular quality control by the ubiquitin-proteasome system and autophagy (2019) Science (New York, N.Y.), 366 (6467), 818–822. http://doi.org/10.1126/science.aax3769

Pollinger, J., Gellrich, L., Schierle, S., Kilu, W., Schmidt, J., Kalinowsky, L., Ohrndorf, J., Kaiser, A., Heering, J., Proschak, E., Merk, D.
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation (2019) Journal of medicinal chemistry, 62 (4), 2112–2126. http://doi.org/10.1021/acs.jmedchem.8b01848

Poluzzi, C., Nastase, M.-V., Zeng-Brouwers, J., Roedig, H., Hsieh, L.T.-H., Michaelis, J.B., Buhl, E.M., Rezende, F., Manavski, Y., Bleich, A., Boor, P., Brandes, R.P., Pfeilschifter, J.M., Stelzer, E.H.K., Münch, C., Dikic, I., Brandts, C.H., Iozzo, R.V., Wygrecka, M., Schaefer, L.
Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury (2019) Kidney international, 95 (3), 540–562. http://doi.org/10.1016/j.kint.2018.10.037

Price, D.J., Ditzinger, F., Koehl, N.J., Jankovic, S., Tsakiridou, G., Nair, A., Holm, R., Kuentz, M., Dressman, J.B., Saal, C.
Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations - a PEARRL review (2019) The Journal of pharmacy and pharmacology, 71 (4), 483–509. http://doi.org/10.1111/jphp.12927

Price, D.J., Nair, A., Kuentz, M., Dressman, J.B., Saal, C.
Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 132, 142–156. http://doi.org/10.1016/j.ejps.2019.03.006

Proschak, E., Stark, H., Merk, D.
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds (2019) Journal of medicinal chemistry, 62 (2), 420–444. http://doi.org/10.1021/acs.jmedchem.8b00760

Queck, A., Thomas, D., Jansen, C., Schreiber, Y., Rüschenbaum, S., Praktiknjo, M., Schwarzkopf, K.M., Mücke, M.M., Schierwagen, R., Uschner, F.E., Meyer, C., Clària, J., Zeuzem, S., Geisslinger, G., Trebicka, J., Lange, C.M.
Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis (2019) PloS one, 14 (10), e0222840. http://doi.org/10.1371/journal.pone.0222840

Rehwald, C., Schnetz, M., Urbschat, A., Mertens, C., Meier, J.K., Bauer, R., Baer, P., Winslow, S., Roos, F.C., Zwicker, K., Huard, A., Weigert, A., Brüne, B., Jung, M.
The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma (2019) British journal of cancer. http://doi.org/10.1038/s41416-019-0655-7

Rosenberger, J., Schmid, K., Schäfer, K., Dressman, J.B.
Surface Activity Profiling (SAP): A potential means of predicting intestinal membrane permeability (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 142, 291–299. http://doi.org/10.1016/j.ejpb.2019.06.024

Rosenberger, J., Butler, J., Muenster, U., Dressman, J.
Application of a Refined Developability Classification System (2019) Journal of pharmaceutical sciences, 108 (3), 1090–1100. http://doi.org/10.1016/j.xphs.2018.10.044

Rühl, M., Kühn, B., Roos, J., Maier, T.J., Steinhilber, D., Karas, M.
Elucidation of chemical modifier reactivity towards peptides and proteins and the analysis of specific fragmentation by matrix-assisted laser desorption/ionization collision-induced dissociation tandem mass spectrometry (2019) Rapid communications in mass spectrometry : RCM, 33 Suppl 1, 40–49. http://doi.org/10.1002/rcm.8223

S – U

Sassetti, E., Durante Cruz, C., Tammela, P., Winterhalter, M., Augustyns, K., Gribbon, P., Windshügel, B.
Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors (2019) International journal of molecular sciences, 20 (11). http://doi.org/10.3390/ijms20112686

Saul, M.J., Baumann, I., Bruno, A., Emmerich, A.C., Wellstein, J., Ottinger, S.M., Contursi, A., Dovizio, M., Donnini, S., Tacconelli, S., Raouf, J., Idborg, H., Stein, S., Korotkova, M., Savai, R., Terzuoli, E., Sala, G., Seeger, W., Jakobsson, P.-J., Patrignani, P., Suess, B., Steinhilber, D.
miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (6), 6933–6947. http://doi.org/10.1096/fj.201802547R

Saul, M.J., Emmerich, A.C., Steinhilber, D., Suess, B.
Regulation of Eicosanoid Pathways by MicroRNAs (2019) Frontiers in pharmacology, 10, 824. http://doi.org/10.3389/fphar.2019.00824

Saul, M.J., Hegewald, A.B., Emmerich, A.C., Ossipova, E., Vogel, M., Baumann, I., Kultima, K., Lengqivst, J., Steinhilber, D., Jakobsson, P.-J.
Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes (2019) Frontiers in pharmacology, 10, 640. http://doi.org/10.3389/fphar.2019.00640

Schmiedl, S., Peters, D., Schmalz, O., Mielke, A., Rossmanith, T., Diop, S., Piefke, M., Thürmann, P., Schmidtko, A.
Loxapine for Treatment of Patients With Refractory, Chemotherapy-Induced Neuropathic Pain: A Prematurely Terminated Pilot Study Showing Efficacy But Limited Tolerability (2019) Frontiers in pharmacology, 10, 838. http://doi.org/10.3389/fphar.2019.00838

Schmitz, K., Wilken-Schmitz, A., Vasic, V., Brunkhorst, R., Schmidt, M., Tegeder, I.
Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice (2019) Cellular & molecular immunology. http://doi.org/10.1038/s41423-019-0274-5

Schömel, N., Hancock, S.E., Gruber, L., Olzomer, E.M., Byrne, F.L., Shah, D., Hoehn, K.L., Turner, N., Grösch, S., Geisslinger, G., Wegner, M.-S.
UGCG influences glutamine metabolism of breast cancer cells (2019) Scientific reports, 9 (1), 15665. http://doi.org/10.1038/s41598-019-52169-7

Schwarzkopf, K.M., Queck, A., Thomas, D., Angioni, C., Cai, C., Freygang, Y., Rüschenbaum, S., Geisslinger, G., Zeuzem, S., Welsch, C., Lange, C.M.
Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation (2019) PloS one, 14 (1), e0211537. http://doi.org/10.1371/journal.pone.0211537

Schwedhelm, I., Zdzieblo, D., Appelt-Menzel, A., Berger, C., Schmitz, T., Schuldt, B., Franke, A., Müller, F.-J., Pless, O., Schwarz, T., Wiedemann, P., Walles, H., Hansmann, J.
Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors (2019) Scientific reports, 9 (1), 12297. http://doi.org/10.1038/s41598-019-48814-w

Schwiebs, A., Herrero San Juan, M., Schmidt, K.G., Wiercinska, E., Anlauf, M., Ottenlinger, F.M., Thomas, D., Elwakeel, E., Weigert, A., Farin, H.F., Bonig, H., Scholich, K., Geisslinger, G., Pfeilschifter, J.M., Radeke, H.H.
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase (2019) Oncogene, 38 (24), 4788–4803. http://doi.org/10.1038/s41388-019-0758-x

Segregur, D., Flanagan, T., Mann, J., Moir, A., Karlsson, E.M., Hoch, M., Carlile, D., Sayah-Jeanne, S., Dressman, J.B.
Impact of Acid-Reducing Agents on Gastrointestinal Physiology and Design of Biorelevant Dissolution Tests to Reflect These Changes (2019) Journal of pharmaceutical sciences, 108 (11), 3461–3477. http://doi.org/10.1016/j.xphs.2019.06.021

Sisignano, M., Lötsch, J., Parnham, M.J., Geisslinger, G.
Potential biomarkers for persistent and neuropathic pain therapy (2019) Pharmacology & therapeutics, 199, 16–29. http://doi.org/10.1016/j.pharmthera.2019.02.004

Sisignano, M., Parnham, M.J., Geisslinger, G.
Novel Approaches to Persistent Pain Therapy (2019) Trends in pharmacological sciences, 40 (6), 367–377. http://doi.org/10.1016/j.tips.2019.04.003

Smelcerovic, A., Zivkovic, A., Ilic, B.S., Kolarevic, A., Hofmann, B., Steinhilber, D., Stark, H.
4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition (2019) Bioorganic chemistry, 95, 103528. http://doi.org/10.1016/j.bioorg.2019.103528

Smith, D., Buddie, A.G., Goss, R.J.M., Overmann, J., Lepleux, C., Brönstrup, M., Kloareg, B., Meiners, T., Brennecke, P., Ianora, A., Bouget, F.-Y., Gribbon, P., Pina, M.
Discovery pipelines for marine resources: an ocean of opportunity for biotechnology? (2019) World journal of microbiology & biotechnology, 35 (7), 107. http://doi.org/10.1007/s11274-019-2685-y

Snodgrass, R.G., Brüne, B.
Regulation and Functions of 15-Lipoxygenases in Human Macrophages (2019) Frontiers in pharmacology, 10, 719. http://doi.org/10.3389/fphar.2019.00719

Susen, R.M., Bauer, R., Olesch, C., Fuhrmann, D.C., Fink, A.F., Dehne, N., Jain, A., Ebersberger, I., Schmid, T., Brüne, B.
Macrophage HIF-2α regulates tumor-suppressive Spint1 in the tumor microenvironment (2019) Molecular carcinogenesis, 58 (11), 2127–2138. http://doi.org/10.1002/mc.23103

Syed, S.N., Frank, A.-C., Raue, R., Brüne, B.
MicroRNA-A Tumor Trojan Horse for Tumor-Associated Macrophages (2019) Cells, 8 (12). http://doi.org/10.3390/cells8121482

Syed, S.N., Raue, R., Weigert, A., von Knethen, A., Brüne, B.
Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation (2019) Cells, 8 (8). http://doi.org/10.3390/cells8080785

Tarighi, N., Menger, D., Pierre, S., Kornstädt, L., Thomas, D., Ferreirós, N., Nüsing, R.M., Geisslinger, G., Scholich, K.
Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation (2019) The Journal of investigative dermatology, 139 (3), 656–664. http://doi.org/10.1016/j.jid.2018.10.011

Tietgen, M., Kramer, J.S., Brunst, S., Djahanschiri, B., Wohra, S., Higgins, P.G., Weidensdorfer, M., Riedel-Christ, S., Pos, K.M., Gonzaga, A., Steglich, M., Nübel, U., Ebersberger, I., Proschak, E., Göttig, S.
Identification of the novel class D β-lactamase OXA-679 involved in carbapenem resistance in Acinetobacter calcoaceticus (2019) The Journal of antimicrobial chemotherapy, 74 (6), 1494–1502. http://doi.org/10.1093/jac/dkz080

Tiku, V., Dikic, I.
Autophagy without conjugation (2019) Nature structural & molecular biology, 26 (4), 249–250. http://doi.org/10.1038/s41594-019-0207-0

Trümper, V., von Knethen, A., Preuß, A., Ermilov, E., Hackbarth, S., Kuchler, L., Gunne, S., Schäfer, A., Bornhütter, T., Vereb, G., Ujlaky-Nagy, L., Brüne, B., Röder, B., Schindler, M., Parnham, M.J., Knape, T.
Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells (2019) Theranostics, 9 (19), 5444–5463. http://doi.org/10.7150/thno.29367

V – Z

van Wijk, S.J., Fulda, S., Dikic, I., Heilemann, M.
Visualizing ubiquitination in mammalian cells (2019) EMBO reports, 20 (2). http://doi.org/10.15252/embr.201846520

Vasconez, A.E., Janetzko, P., Oo, J.A., Pflüger-Müller, B., Ratiu, C., Gu, L., Helin, K., Geisslinger, G., Fleming, I., Schröder, K., Fork, C., Brandes, R.P., Leisegang, M.S.
The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase (2019) Acta physiologica (Oxford, England), 225 (1), e13168. http://doi.org/10.1111/apha.13168

Vieider, L., Romp, E., Temml, V., Fischer, J., Kretzer, C., Schoenthaler, M., Taha, A., Hernández-Olmos, V., Sturm, S., Schuster, D., Werz, O., Garscha, U., Matuszczak, B.
Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors (2019) ACS medicinal chemistry letters, 10 (1), 62–66. http://doi.org/10.1021/acsmedchemlett.8b00415

Villa Nova, M., Nothnagel, L., Thurn, M., Travassos, P.B., Herculano, L.S., Bittencourt, P.R.S., Novello, C.R., Bazotte, R.B., Wacker, M.G., Bruschi, M.L.
Development study of pectin/Surelease® solid microparticles for the delivery of L-alanyl-L-glutamine dipeptide (2019) Food Hydrocolloids, 89, 921–932. http://doi.org/10.1016/j.foodhyd.2018.11.038

von Knethen, A., Brüne, B.
Histone Deacetylation Inhibitors as Therapy Concept in Sepsis (2019) International journal of molecular sciences, 20 (2). http://doi.org/10.3390/ijms20020346

von Knethen, A., Brüne, B.
PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology (2019) Signal transduction and targeted therapy, 4, 18. http://doi.org/10.1038/s41392-019-0053-x

von Knethen, A., Schäfer, A., Kuchler, L., Knape, T., Christen, U., Hintermann, E., Fißlthaler, B., Schröder, K., Brandes, R.P., Genz, B., Abshagen, K., Pützer, B.M., Sha, L.K., Weigert, A., Syed, S.N., Schulz, M., Shah, A.M., Ernst, A., Putyrski, M., Finkelmeier, F., Pesic, M., Greten, F., Hogardt, M., Kempf, V.A.J., Gunne, S., Parnham, M.J., Brüne, B.
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis (2019) Theranostics, 9 (7), 2003–2016. http://doi.org/10.7150/thno.28057

Wallenwein, C.M., Villa Nova, M., Janas, C., Jablonka, L., Gao, G.F., Thurn, M., Albrecht, V., Wiehe, A., Wacker, M.G.
A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 143, 44–50. http://doi.org/10.1016/j.ejpb.2019.08.010

Walter, C., Oertel, B.G., Felden, L., Nöth, U., Deichmann, R., Lötsch, J.
Delta-9-tetrahydrocannabinol reduces the performance in sensory delayed discrimination tasks. A pharmacological-fMRI study in healthy volunteers (2019) IBRO reports, 7, 117–128. http://doi.org/10.1016/j.ibror.2019.11.004

Wegner, M.-S., Gruber, L., Schömel, N., Trautmann, S., Brachtendorf, S., Fuhrmann, D.C., Schreiber, Y., Olesch, C., Brüne, B., Geisslinger, G., Grösch, S.
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells (2019) The international journal of biochemistry & cell biology, 112, 95–106. http://doi.org/10.1016/j.biocel.2019.05.002

Wegner, M., Diehl, V., Bittl, V., Bruyn, R. de, Wiechmann, S., Matthess, Y., Hebel, M., Hayes, M.G., Schaubeck, S., Benner, C., Heinz, S., Bremm, A., Dikic, I., Ernst, A., Kaulich, M.
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome (2019) eLife, 8. http://doi.org/10.7554/eLife.42549

Weigert, A., Olesch, C., Brüne, B.
Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater (2019) Frontiers in immunology, 10, 1706. http://doi.org/10.3389/fimmu.2019.01706

Weigert, A., von Knethen, A., Thomas, D., Faria, I., Namgaladze, D., Zezina, E., Fuhrmann, D.C., Petcherski, A., Heringdorf, D.M.Z., Radeke, H.H., Brüne, B.
Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation (2019) Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864 (9), 1235–1246. http://doi.org/10.1016/j.bbalip.2019.05.008

Weyer-Menkhoff, I., Lötsch, J.
TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers (2019) The Clinical journal of pain, 35 (4), 321–327. http://doi.org/10.1097/AJP.0000000000000677

Weyer-Menkhoff, I., Pinter, A., Schlierbach, H., Schänzer, A., Lötsch, J.
Epidermal expression of human TRPM8, but not of TRPA1 ion channels, is associated with sensory responses to local skin cooling (2019) Pain, 160 (12), 2699–2709. http://doi.org/10.1097/j.pain.0000000000001660

Yuki, K.E., Marei, H., Fiskin, E., Eva, M.M., Gopal, A.A., Schwartzentruber, J.A., Majewski, J., Cellier, M., Mandl, J.N., Vidal, S.M., Malo, D., Dikic, I.
CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection (2019) Nature microbiology, 4 (9), 1516–1531. http://doi.org/10.1038/s41564-019-0484-8

Zschiebsch, K., Fischer, C., Wilken-Schmitz, A., Geisslinger, G., Channon, K., Watschinger, K., Tegeder, I.
Mast cell tetrahydrobiopterin contributes to itch in mice (2019) Journal of cellular and molecular medicine, 23 (2), 985–1000. http://doi.org/10.1111/jcmm.13999

A - C

Al-Hujaily, E.M., Khatlani, T., Alehaideb, Z., Ali, R., Almuzaini, B., Alrfaei, B.M., Iqbal, J., Islam, I., Malik, S., Marwani, B.A., Massadeh, S., Nehdi, A., Alsomaie, B., Debasi, B., Bushnak, I., Noibi, S., Hussain, S., Wajid, W.A., Armand, J.P., Gul, S., Oyarzabal, J., Rais, R., Bountra, C., Alaskar, A., Knawy, B.A., Boudjelal, M.
Therapeutics discovery: from bench to first in-human trials (2018) Biomedical Reports, 8, 275-282. http://doi.org/10.3892/br.2018.1052

Alten, R., Burkhardt, H., Feist, E., Krüger, K., Rech, J., Rubbert-Roth, A., Voll, R.E., Elbez, Y., Rauch, C.
Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: A descriptive analysis of data from interventional trials and the real-world setting (2018) Arthritis Research and Therapy, 20 (1), 1. http://doi.org/10.1186/s13075-017-1488-5

Ashtikar, M., Wacker, M.G.
Nanopharmaceuticals for wound healing – Lost in translation? (2018) Advanced Drug Delivery Reviews, 129, 194-218. http://doi.org/10.1016/j.addr.2018.03.005

Aygören-Pürsün, E., Bygum, A., Grivcheva-Panovska, V., Magerl, M., Graff, J., Steiner, U.C., Fain, O., Huissoon, A., Kinaciyan, T., Farkas, H., Lleonart, R., Longhurst, H.J., Rae, W., Triggiani, M., Aberer, W., Cancian, M., Zanichelli, A., Smith, W.B., Baeza, M.L., Du-Thanh, A., Gompels, M., Gonzalez-Quevedo, T., Greve, J., Guilarte, M., Katelaris, C., Dobo, S., Cornpropst, M., Clemons, D., Fang, L., Collis, P., Sheridan, W., Maurer, M., Cicardi, M.
Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema (2018) New England Journal of Medicine, 379 (4), 352-362. http://doi.org/10.1056/NEJMoa1716995

Badalyan, G., Díaz, C., Bücking, M., Lipski, A.
Novel sensor platform for rapid detection and quantification of coliforms on food contact surfaces (2018) Journal of Microbiological Methods, 153, 74-83. http://doi.org/10.1016/j.mimet.2018.09.009

Behrens, F., Koehm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab (2018) Rheumatology (Oxford, England), 57 (11), 1938-1946. http://doi.org/10.1093/rheumatology/key203

Behrens, F., Meier, L., Prinz, J.C., Jobst, J., Lippe, R., Löschmann, P.-A., Lorenz, H.-M.
Simultaneous response in several domains in patients with psoriatic disease treated with etanercept as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (2018) Journal of Rheumatology, 45 (6), 802-810. http://doi.org/10.3899/jrheum.170932

Blum, L., Schiffmann, S., Parnham, M.J.
Immunomodulation by antibiotics (2018) Fighting Antimicrobial Resistance (IAPC Book). http://doi.org/10.5599/obp.15.11

Blum, L., Tafferner, N., Spring, I., Kurz, J., deBruin, N., Geißlinger, G., Parnham, M.J., Schiffmann, S.
Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression (2018) Journal of Molecular Medicine, 96 (10), 1131-1144. http://doi.org/10.1007/s00109-018-1689-7

Böhm, B.B., Fehrl, Y., Janczi, T., Schneider, N., Burkhardt, H.
Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation (2018) PLoS ONE, 13 (9), e203847. http://doi.org/10.1371/journal.pone.0203847

Bosma, R., Witt, G., Vaas, L.A.I., Josimovic, I., Gribbon, P., Vischer, H.F., Gul, S., Leurs, R.
The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor (2017) Front Pharmacol, 8:667. http://doi.org/10.3389/fphar.2017.00667

Brachtendorf, S., Wanger, R.A., Birod, K., Thomas, D., Trautmann, S., Wegner, M.-S., Fuhrmann, D.C., Brüne, B., Geißlinger, G., Grösch, S.
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (10), 1214-1227. http://doi.org/10.1016/j.bbalip.2018.07.011

Brand, S., Roy, S., Schröder, P., Rathmer, B., Roos, J., Kapoor, S., Patil, S., Pommerenke, C., Maier, T., Janning, P., Eberth, S., Steinhilber, D., Schade, D., Schneider, G., Kumar, K., Ziegler, S., Waldmann, H.
Combined proteomic and in silico target identification reveal a role for 5-Lipoxygenase in developmental signaling pathways (2018) Cell Chemical Biology, 25 (9), 1095-1106.e23. http://doi.org/10.1016/j.chembiol.2018.05.016

Brandt, S.C., Ellinger, B., van Nguyen, T., Thi, Q.D., van Nguyen, G., Baschien, C., Yurkov, A., Hahnke, R.L., Schäfer, W., Gand, M.
A unique fungal strain collection from Vietnam characterized for high performance degraders of bioecological important biopolymers and lipids (2018) PLoS ONE, 13(8). http://doi.org/10.1371/journal.pone.0202695

Büttner, D., Kramer, J.S., Klingler, F.-M., Wittmann, S.K., Hartmann, M.R., Kurz, C.G., Kohnhäuser, D., Weizel, L., Brüggerhoff, A., Frank, D., Steinhilber, D., Wichelhaus, T.A., Pogoryelov, D., Proschak, E.
Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases (2018) ACS Infectious Diseases, 4 (3), 360-372. http://doi.org/10.1021/acsinfecdis.7b00129

Burk, O., Kuzikov, M., Kronenberger, T., Jeske, J., Keminer, O., Thasler, W.E., Schwab, M., Wrenger, C., Windshügel, B.
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) Archives of Toxicology, 92 (4), 1435-1451. http://doi.org/10.1007/s00204-018-2165-4

D – F

Dauth, S., Köhm, M., Rossmanith, T., Herrmann, E., Lehn, A., Burkhardt, H., Behrens, F.
Stellenwert der Kombination von Biologika mit Methotrexat in der Behandlung der Psoriasisarthritis - Fragen bleiben offen (2018) Zeitschrift fur Rheumatologie.  http://doi.org/10.1007/s00393-018-0533-3

de Bruin, N., Ferreirós, N., Schmidt, M., Hofmann, M., Angioni, C., Geisslinger, G., Parnham, M.J. Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains (2018) Chirality, 30 (5), 632-641. http://doi.org/10.1002/chir.22826

de Witte, W.E.A., Versfelt, J.W., Kuzikov, M., Rolland, S., Georgi, V., Gribbon, P., Gul, S., Huntjens, D., van der Graaf, P.H., Danhof, M., Fernández-Montalván, A., Witt, G., de Lange, E.C.M.
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations (2018) Br J Pharmacol, 175 (21), 4121-4136. http://doi.org/10.1111/bph.14456

Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreirós, N., Schreiber, Y., Schröder, K., Devraj, K., Popp, R., Hattenbach, L.-O., Pfeilschifter, J., Pfeilschifter, W.Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy(2018) Investigative Ophthalmology and Visual Science, 59 (2), 653-661. http://doi.org/10.1167/iovs.17-22544

Fiehn, C., Holle, J., Iking-Konert, C., Leipe, J., Weseloh, C., Frerix, M., Alten, R., Behrens, F., Baerwald, C., Braun, J., Burkhardt, H., Burmester, G., Detert, J., Gaubitz, M., Gause, A., Gromnica-Ihle, E., Kellner, H., Krause, A., Kuipers, J., Lorenz, H.-M., Müller-Ladner, U., Nothacker, M., Nüsslein, H., Rubbert-Roth, A., Schneider, M., Schulze-Koops, H., Seitz, S., Sitter, H., Specker, C., Tony, H.-P., Wassenberg, S., Wollenhaupt, J., Krüger, K.
S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs (2018) Zeitschrift fur Rheumatologie, 77, 35-53. http://doi.org/10.1007/s00393-018-0481-y

Genovese, M.C., Combe, B., Kremer, J.M., Tsai, T.-F., Behrens, F., Adams, D.H., Lee, C., Kerr, L., Nash, P.
Safety and efficacy of ixekizumab in patients with PsA and previous inadequate response to TNF inhibitors: week 52 results from SPIRIT-P2 (2018) Rheumatology (Oxford, England), 57 (11), 2001-2011. http://doi.org/10.1093/rheumatology/key182

Gossec, L., McGonagle, D., Korotaeva, T., Lubrano, E., De Miguel, E., Østergaard, M., Behrens, F. Minimal disease activity as a treatment target in psoriatic arthritis: A review of the literature (2018) Journal of Rheumatology, 45 (1), 6-13. http://doi.org/10.3899/jrheum.170449

Häupl, T., Skapenko, A., Hoppe, B., Skriner, K., Burkhardt, H., Poddubnyy, D., Ohrndorf, S., Sewerin, P., Mansmann, U., Stuhlmüller, B., Schulze-Koops, H., Burmester, G.R.
Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark (2018) Zeitschrift fur Rheumatologie, 77, 16-23. http://doi.org/10.1007/s00393-018-0458-x

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R.
Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos (2018) Environmental Science and Pollution Research, 25 (5), 4023-4036. http://doi.org/10.1007/s11356-017-8977-6

Heitel, P., Gellrich, L., Heering, J., Goebel, T., Kahnt, A., Proschak, E., Schubert-Zsilavecz, M., Merk, D.
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro (2018) Scientific Reports, 8 (1), 13554. http://doi.org/10.1038/s41598-018-31833-4

Hering, Y., Berthier, A., Duez, H., Lefebvre, P., Deprez, B., Gribbon, P., Wolf, M., Reinshagen, J., Halley, F., Hannemann, J., Böger, R., Staels, B., Gul, S.
Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα (2018) Journal of Biological Methods, 5 (3), e94. http://doi.org/10.1038/s41598-018-31833-4

Hitzel, J., Lee, E., Zhang, Y., Bibli, S.I., Li, X., Zukunft, S., Pflüger, B., Hu, J., Schürmann, C., Vasconez, A.E., Oo, J.A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C.E., Kroll, J., Jo, H., Landmesser, U., Lusis, A.J., Namgaladze, D., Fleming, I., Leisegang, M.S., Zhu, J., Brandes, R.P. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) Nature Communications, 9 (1), art. no. 2292. http://doi.org/10.1038/s41467-018-04602-0

Hofmann, M.C.J., Schmidt, M., Arne, O., Geisslinger, G., Parnham, M.J., de Bruin, N.M.W.J.
Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation (2018) Journal of Dermatological Science, 91 (2), 153-163. http://doi.org/10.1016/j.jdermsci.2018.04.013

Jung, F., Nothnagel, L., Gao, F., Thurn, M., Vogel, V., Wacker, M.G. A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling (2018) European Journal of Pharmaceutics and Biopharmaceutics, 127, 462-470. http://doi.org/10.1016/j.ejpb.2018.03.010

Kern, K., Schäfer, S.M.G., Cohnen, J., Pierre, S., Osthues, T., Tarighi, N., Hohmann, S., Ferreiros, N., Brüne, B., Weigert, A., Geißlinger, G., Sisignano, M., Scholich, K.
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue (2018) Frontiers in Immunology, 9, 2261. http://doi.org/10.3389/fimmu.2018.02261

Kirchner, J., Brüne, B., Namgaladze, D. AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages (2018) Scientific Reports, 8 (1), art. no. 7801, http://doi.org/10.1038/s41598-018-26102-3

Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreirós, N., Geißlinger, G., Batista, V.S., Ji, X., Cinatl, J. Jr., Keppler, O.T., Xiong, Y.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 (2018) Proceedings of the National Academy of Sciences of the United States of America, 115 (43), E10022-E10031. http://doi.org/10.1073/pnas.1805593115

Kraft, C., Boya, P., Codogno, P., Elazar, Z., Eskelinen, E.-L., Farrés, J., Kirkin, V., Jungbluth, H., Martinez, A., Pless, O., Primard, C., Proikas-Cezanne, T., Simonsen, A., Reggiori, F.
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy (2018) Autophagy. 13,1-5. Online first. http://doi.org/10.1080/15548627.2018.1515532Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E. A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E.
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kringel, D., Geißlinger, G., Resch, E., Oertel, B.G., Thrun,M.C., Heinemann, S., Lötsch, J.
Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin (2018) Pain, 159 (7), 1366-1381. http://doi.org/10.1097/j.pain.0000000000001222

Kringel, D., Kaunisto, M.A., Lippmann, C., Kalso, E., Lötsch, J.
Development of an AmpliSeqTMPanel for next-generation sequencing of a set of genetic predictors of persisting pain (2018) Frontiers in Pharmacology, 9, 1008. http://doi.org/10.3389/fphar.2018.01008

Kringel, D., Lippmann, C., Parnham, M.J., Kalso, E., Ultsch, A., Lötsch, J.
A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes (2018) European Journal of Pain, 22 (10), 1735-1756. http://doi.org/10.1002/ejp.1270

Kronenberger, T., Windshügel, B., Wrenger, C., Honorio, K.M., Maltarollo, V.G. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity (2018) Journal of Biomolecular Structure and Dynamics, 1-14. Article in Press. http://doi.org/10.1080/07391102.2017.1417161

Kühn, B., Brat, C., Fettel, J., Hellmuth, N., Maucher, I.V., Bulut, U., Hock, K.J., Grimmer, J., Manolikakes, G., Rühl, M., Kühn, A., Zacharowski, K., Matrone, C., Urbschat, A., Roos, J., Steinhilber, D., Maier, T.J.
Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells (2018) Biochemical Pharmacology, 155, 48-60. http://doi.org/10.1016/j.bcp.2018.06.014

Kurz, J., Brunkhorst, R., Foerch, C., Blum, L., Henke, M., Gabriel, L., Ulshöfer, T., Ferreirós, N., Parnham, M.J., Geißlinger, G., Schiffmann, S.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis (2018) Clinical Science, 132 (17), 1963-1976. http://doi.org/10.1042/CS20180506

Linciano, P., Moraes, C.B., Alcantara, L.M., Franco, C.H., Pascoalino, B., Freitas-Junior, L.H., Macedo, S., Santarem, N., Cordeiro-da-Silva, A., Gul, S., Witt, G., Kuzikov, M., Ellinger, B., Ferrari, S., Luciani, R., Quotadamo, A., Costantino, L., Costi, M.P.
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections (2018) European Journal of Medicinal Chemistry, 25;146, 423-434. http://doi.org/10.1016/j.ejmech.2018.01.043

Lippmann, C., Kringel, D., Ultsch, A., Lötsch, J. Computational functional genomics-based approaches in analgesic drug discovery and repurposing (2018) Pharmacogenomics, 19 (9), 783-797. http://doi.org/10.2217/pgs-2018-0036

Lötsch, J., Geisslinger, G., Heinemann, S., Lerch, F., Oertel, B.G., Ultsch, A.
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: A machine-learned analysis (2018) Pain, 159 (1), 11-24. http://doi.org/10.1097/j.pain.0000000000001008

Lötsch, J., Kringel, D.
Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications (2018) Clinical Pharmacology and Therapeutics, . Article in Press. http://doi.org/10.1002/cpt.960

Lötsch, J., Lerch, F., Djaldetti, R., Tegder, I., Ultsch, A.
dentification of disease-distinct complex biomarker patterns by means of unsupervised machine-learning using an interactive R toolbox (Umatrix) (2018) BMC Big Data Analytics, 3. http://doi.org/10.1186/s41044-018-0032-1

Lötsch, J., Schiffmann, S., Schmitz, K., Brunkhorst, R., Lerch, F., Ferreiros, N., Wicker, S., Tegeder, I., Geißlinger, G., Ultsch, A.
Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy (2018) Scientific Reports, 8 (1), 14884. http://doi.org/10.1038/s41598-018-33077-8

Lötsch, J., Sipilä, R., Dimova, V., Kalso, E.
Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery (2018) British Journal of Anaesthesia, 121 (5), 1123-1132. http://doi.org/10.1016/j.bja.2018.06.007

Lötsch, J., Sipilä, R., Tasmuth, T., Kringel, D., Estlander, A.-M., Meretoja, T., Kalso, E., Ultsch, A. Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy (2018) Breast Cancer Research and Treatment, 1-13. Article in Press. http://doi.org/10.1007/s10549-018-4841-8

Lötsch, J., Ultsch, A.
Machine learning in pain research (2018) Pain, 159 (4), 623-630. http://doi.org/10.1097/j.pain.0000000000001118

Lötsch, J., Weyer-Menkhoff, I., Tegeder, I. Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings (2018) European Journal of Pain (United Kingdom), 22 (3), 471-484. http://doi.org/10.1002/ejp.1148

Lukin, A., Kramer, J., Hartmann, M., Weizel, L., Hernandez-Olmos, V., Falahati, K., Burghardt, I., Kalinchenkova, N., Bagnyukova, D., Zhurilo, N., Rautio, J., Forsberg, M., Ihalainen, J., Auriola, S., Leppänen, J., Konstantinov, I., Pogoryelov, D., Proschak, E., Dar‘in, D., Krasavin, M.
Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase (2018) Bioorganic Chemistry, 80, 655-667. http://doi.org/10.1016/j.bioorg.2018.07.014

M – O

Maltarollo, V.G., Kronenberger, T., Windshugel, B., Wrenger, C., Trossini, G.H.G., Honorio, K.M.
Advances and Challenges in Drug Design of PPARδ Ligands (2018) Curr Drug Targets. 19 (2),144-154. http://doi.org/10.2174/1389450118666170414113159

Mertens, C., Mora, J., Ören, B., Grein, S., Winslow, S., Scholich, K., Weigert, A., Malmström, P., Forsare, C., Fernö, M., Schmid, T., Brüne, B., Jung, M.
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment (2018) OncoImmunology, 7 (3), e1408751. http://doi.org/10.1080/2162402X.2017.1408751

Moreno-Cinos, C., Sassetti, E., Salado, IG., Witt, G., Benramdane, S., Reinhardt, L., Durante Cruz, C., Joossens, J., Van der Veken, P., Brotz-Oesterhelt, H., Tammela, P., Winterhalter, M., Gribbon, P., Windshügel, B., Augustyns, K.
α-Amino diphenyl phosphonates as novel inhibitors of ­Escherichia coli ClpP protease (2018) Journal of Medicinal Chemistry, American Chemical Society. Online first. http://doi.org/10.1021/acs.jmedchem.8b01466.

Nash, P., Behrens, F., Orbai, A.-M., Rathmann, S.S., Adams, D.H., Benichou, O., Deodhar, A.
Ixekizumab is efficacious when used alone or when added to conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inhibitors (2018) RMD Open, 4 (2), e000692. http://doi.org/10.1136/rmdopen-2018-000692

Nothnagel, L., Wacker, M.G. How to measure release from nanosized carriers? (2018) European Journal of Pharmaceutical Sciences, 120, 199-211. http://doi.org/10.1016/j.ejps.2018.05.004

P – R

Patas, K., Willing, A., Demiralay, C., Engler, J.B., Lupu, A., Ramien, C., Schäfer, T., Gach, C., Stumm, L., Chan, K., Vignali, M., Arck, P.C., Friese, M.A., Pless, O., Wiedemann, K., Agorastos, A., Gold, S.M. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder (2018) Frontiers in Immunology, 9 (FEB), art. no. 291, http://doi.org/10.3389/fimmu.2018.00291

Piña, M., Colas, P., Cancio, I., Audic, A., Bosser, L., Canario, A., Gribbon, P., Johnston, IA., Kervella, AE., Kooistra, WHCF., Merciecca, M., Magoulas, A., Nardello, I., Smith, D., Pade, N., Robinson, D., Schoen, A., Schultz, F., Kloareg, B.
The European Marine Biological Research Infrastructure Cluster: An Alliance of European Research Infrastructures to Promote the Blue Bioeconomy (2018) Grand Challenges in Marine Biotechnology, Springer, 405-421. http://doi.org/10.1007/978-3-319-69075-9_10

Pleli, T., Mondorf, A., Ferreiros, N., Thomas, D., Dvorak, K., Biondi, R.M., Heringdorf, D.M.Z., Zeuzem, S., Geißlinger, G., Zimmermann, H., Waidmann, O., Piiper, A.
Activation of adenylyl cyclase causes stimulation of adenosine receptors (2018) Cellular Physiology and Biochemistry, 45 (6), 2516-2528. http://doi.org/10.1159/000488270

Proft, F., Schulze-Koops, H., Grunke, M., Schrezenmeier, E., Halleck, F., Henes, J., Unger, L., Schmidt, E., Fiehn, C., Jacobi, A., Iking-Konert, C., Kneitz, C., Schmidt, R.E., Bannert, B., Voll, R.E., Fischer-Betz, R., Kötter, I., Tony, H.P., Holle, J., Aringer, M., Erler, A., Behrens, F., Burmester, G.R., Dörner, T.
Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy: Data from a nationwide German registry (GRAID2) [Sicherheit und Wirksamkeitshinweise zum Off-label-Einsatz von Biologikatherapien nach Versagen konventioneller Therapien bei Patienten mit entzündlich rheumatischen Erkrankungen: Ergebnisse eines nationalen Registers (GRAID2)] (2018) Zeitschrift fur Rheumatologie, 77 (1), 28-39. http://doi.org/10.1007/s00393-017-0330-4

Ringleb, J., Strack, E., Angioni, C., Geißlinger, G., Steinhilber, D., Weigert, A., Brüne, B.
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages (2018) Journal of Immunology, 200 (2), 857-868. http://doi.org/10.4049/jimmunol.1700609

Roos, J., Peters, M., Maucher, I.V., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Sommer, B., Urbschat, A., Piesche, M., Vogel, A., Proschak, E., Blöcher, R., Buscató, E., Häfner, A.-K., Matrone, C., Werz, O., Heidler, J., Wittig, I., Angioni, C., Geisslinger, G., Parnham, M.J., Zacharowski, K., Steinhilber, D., Maier, T.J. Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy (2018) Antioxidants and Redox Signaling, 28 (14), 1265-1285. http://doi.org/10.1089/ars.2017.7155

S – U

Sala, A., Proschak, E., Steinhilber, D., Rovati, G.E.
Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade (2018) Biochemical Pharmacology, 158, 161-173. http://doi.org/10.1016/j.bcp.2018.10.007

Schierle, S., Flauaus, C., Heitel, P., Willems, S., Schmidt, J., Kaiser, A., Weizel, L., Goebel, T., Kahnt, A.S., Geißlinger, G., Steinhilber, D., Wurglics, M., Rovati, G.E., Schmidtko, A., Proschak, E., Merk, D.
Boosting anti-inflammatory potency of zafirlukast by designed polypharmacology (2018) Journal of Medicinal Chemistry, 61 (13), 5758-5764. http://doi.org/10.1021/acs.jmedchem.8b00458

Sehnert, B., Burkhardt, H., Finzel, S., Dübel, S., Voll, R.E. The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways (2018) Clinical Immunology, 186,  14-20. http://doi.org/10.1016/j.clim.2017.08.018

Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A.F., Brüne, B., Rodriguez-Barbosa, J.I., Weigert, A. Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma (2018) International Journal of Molecular Sciences, 19 (3), art. no. 752, http://doi.org/10.3390/ijms19030752

Shiratori, H., Feinweber, C., Luckhardt, S., Wallner, N., Geisslinger, G., Weigert, A., Parnham, M.J. An in vitro test system for compounds that modulate human inflammatory macrophage polarization (2018) European Journal of Pharmacology, 833, 328-338. http://doi.org/10.1016/j.ejphar.2018.06.017

Snodgrass, R.G., Zezina, E., Namgaladze, D., Gupta, S., Angioni, C., Geißlinger, G., Lütjohann, D., Brüne, B.
A novel function for 15-Lipoxygenases in cholesterol homeostasis and CCL17 production in human macrophages. (2018) Front Immunol 1906 (9), 1-16. http://doi.org/10.3389/fimu.2018.01906

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M.
Comparative analysis of the transcriptome responses of zebrafish embryos after exposure to low concentrations of cadmium, cobalt and copper (2018) Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 25, 99-108. http://doi.org/10.1016/j.cbd.2017.12.001

Spry, C., Sewell, A.L., Hering, Y., Villa, M.V.J., Weber, J., Hobson, S.J., Harnor, S.J., Gul, S., Marquez, R., Saliba, K.J. Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation http://doi.org/10.1016/j.ejmech.2017.08.050

Stoessel, D., Stellmann, J.-P., Willing, A., Behrens, B., Rosenkranz, S.C., Hodecker, S.C., Stürner, K.H., Reinhardt, S., Fleischer, S., Deuschle, C., Maetzler, W., Berg, D., Heesen, C., Walther, D., Schauer, N., Friese, M.A., Pless, O.
Metabolomic profiles for primary progressive multiple sclerosis stratification and disease course monitoring (2018) Frontiers in Human Neuroscience, 12, 226. http://doi.org/10.3389/fnhum.2018.00226

Stürner, K.H., Stellmann, J.-P., Dörr, J., Paul, F., Friede, T., Schammler, S., Reinhardt, S., Gellissen, S., Weissflog, G., Faizy, T.D., Werz, O., Fleischer, S., Vaas, L.A.I., Herrmann, F., Pless, O., Martin, R., Heesen, C.
A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) (2018) Journal of Neurology, Neurosurgery and Psychiatry, 89 (4), 330-338. http://doi.org/10.1136/jnnp-2017-317101

Tandon, R., Brändl, B., Baryshnikova, N., Landshammer, A., Steenpaß, L., Keminer, O., Pless, O., Müller, F.-J.
Generation of two human isogenic iPSC lines from fetal dermal fibroblasts (2018) Stem Cell Research, 33, 120-124. http://doi.org/10.1016/j.scr.2018.10.004

Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigrudsson, T., Hauser, M.J., Tenzer, S., Distler, U., Aoki, J., Morris, A.J., Geißlinger, G., Röper, J., Kirischuk, S., Luhmann, H.J., Radyushkin, K., Nitsch, R., Vogt, J.
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (2018) Molecular Psychiatry, 23 (8), 1699-1710. http://doi.org/10.1038/s41380-018-0053-1

Toewe, A., Balas, L., Durand, T., Geisslinger, G., Ferreirós, N. Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry (2018) Analytica Chimica Acta, . Article in Press. http://doi.org/10.1016/j.aca.2018.05.020

Treutlein, E.-M., Kern, K., Weigert, A., Tarighi, N., Schuh, C.-D., Nüsing, R.M., Schreiber, Y., Ferreirós, N., Brüne, B., Geißlinger, G., Pierre, S., Scholich, K.
The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage (2018) Journal of Biological Chemistry, 293 (25), 9685-9695. http://doi.org/10.1074/jbc.RA118.002492

Trillhaase, A., Haferkamp, U., Rangnau, A., Märtens, M., Schmidt, B., Trilck, M., Seibler, P., Aherrahrou, R., Erdmann, J., Aherrahrou, Z.
Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells (2018) Stem Cell Research, 31, 62-70. http://doi.org/10.1016/j.scr.2018.07.008

Tunaru, S., Bonnavion, R., Brandenburger, I., Preussner, J., Thomas, D., Scholich, K., Offermanns, S.
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 (2018) Nature Communications, 9 (1), 177. http://doi.org/10.1038/s41467-017-02539-4

Uliassi, E., Piazzi, L., Belluti, F., Mazzanti, A., Kaiser, M., Brun, R., Moraes, C.B., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Ellinger, B., Borsari, C., Costi, M.P., Bolognesi, M.L.
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections (2018) ChemMedChem, 13 (7), 678-683. http://doi.org/10.1002/cmdc.201700786

V – Z

Van Vollenhoven, R.F., Keystone, E.C., Strand, V., Pacheco-Tena, C., Vencovský, J., Behrens, F., Racewicz, A., Zipp, D., Rharbaoui, F., Wolter, R., Knierim, L., Schmeidl, R., Zhou, X., Aigner, S., Dälken, B., Wartenberg-Demand, A.
Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase IIb, randomised, placebo-controlled trial (2018) Annals of the Rheumatic Diseases, 77 (4), 495-499. http://doi.org/10.1136/annrheumdis-2017-212478

Vögtle, F.-N., Brändl, B., Larson, A., Pendziwiat, M., Friederich, M.W., White, S.M., Basinger, A., Kücükköse, C., Muhle, H., Jähn, J.A., Keminer, O., Helbig, K.L., Delto, C.F., Myketin, L., Mossmann, D., Burger, N., Miyake, N., Burnett, A., van Baalen, A., Lovell, M.A., Matsumoto, N., Walsh, M., Yu, H.-C., Shinde, D.N., Stephani, U., Van Hove, J.L.K., Müller, F.-J., Helbig, I.
Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood (2018) American Journal of Human Genetics, 102 (4), 557-573. http://doi.org/10.1016/j.ajhg.2018.02.014

Vollert, J., Magerl, W., Baron, R., Binder, A., Enax-Krumova, E.K., Geißlinger, G., Gierthmuhlen, J., Henrich, F., Hullemann, P., Klein, T., Lotsch, J., Maier, C., Oertel, B., Schuh-Hofer, S., Tolle, T.R., Treede, R.-D.
Pathophysiological mechanisms of neuropathic pain: Comparison of sensory phenotypes in patients and human surrogate pain models (2018) Pain, 159 (6), 1090-1102. http://doi.org/10.1097/j.pain.0000000000001190

Wacker, M.G., Janas, C., Ferreira, F.S., Vieira, F.P.
Manufacturing and Safety Guidelines for Manufactured Functionalized Nanomaterials in Pharmaceutics (2018) Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation, 623-651. http://doi.org/10.1016/B978-0-323-50878-0.00021-5

Wegner, M.-S., Gruber, L., Mattjus, P., Geißlinger, G., Grösch, S.
The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1) (2018) BMC Cancer, 18 (1), 153. http://doi.org/10.1186/s12885-018-4084-4

Wegner, M.-S., Schömel, N., Gruber, L., Örtel, S.B., Kjellberg, M.A., Mattjus, P., Kurz, J., Trautmann, S., Peng, B., Wegner, M., Kaulich, M., Ahrends, R., Geisslinger, G., Grösch, S.
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018) Cellular and Molecular Life Sciences, 75 (18), 3393-3410. http://doi.org/10.1007/s00018-018-2799-7

Weigert, A., von Knethen, A., Fuhrmann, D., Dehne, N., Brüne, B. Redox-signals and macrophage biology (for the upcoming issue of molecular aspects of medicine on signaling by reactive oxygen species) (2018) Molecular Aspects of Medicine, http://doi.org/10.1016/j.mam.2018.01.003

Weyer-Menkhoff, I., Lötsch, J.
Human pharmacological approaches to TRP-ion-channel-based analgesic drug development (2018) Drug Discovery Today, 23 (12), 2003-2012, http://doi.org/10.1016/j.drudis.2018.06.020

Weyer-Menkhoff, I., Thrun, M.C., Lötsch, J. Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects (2018) European Journal of Pain (United Kingdom), 22 (5), 862-874. http://doi.org/10.1002/ejp.1173

Winau, L., Hinojar Baydes, R., Braner, A., Drott, U., Burkhardt, H., Sangle, S., D‘Cruz, D.P., Carr-White, G., Marber, M., Schnoes, K., Arendt, C., Klingel, K., Vogl, T.J., Zeiher, A.M., Nagel, E., Puntmann, V.O.
High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus (2018) Annals of the Rheumatic Diseases, 77 (11), 1590-1598. http://doi.org/10.1136/annrheumdis-2018-213661

Windshügel, B.
Structural Insights into Ligand-Binding Pocket Formation in Nurr1 by Molecular Dynamics Simulations (2018) Journal of Biomolecular Structure and Dynamics. http://doi.org/10.1080/07391102.2018.1559099

Zezina, E., Snodgrass, R.G., Schreiber, Y., Zukunft, S., Schürmann, C., Heringdorf, D.M.Z., Geißlinger, G., Fleming, I., Brandes, R.P., Brüne, B., Namgaladze, D.
Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (4), 433-446. http://doi.org/10.1016/j.bbalip.2018.01.009

Zhong, J., Scholz, T., Yau, A.C.Y., Guerard, S., Hüffmeier, U., Burkhardt, H., Holmdahl, R.
Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes (2018) Science Advances, 4 (5), eaas9864. http://doi.org/10.1126/sciadv.aas9864

Zimmer, B., Angioni, C., Osthues, T., Toewe, A., Thomas, D., Pierre, S.C., Geisslinger, G., Scholich, K., Sisignano, M. The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (7), 669-678. http://doi.org/10.1016/j.bbalip.2018.03.012

Behrens, F., Thaci, D., Wollenhaupt, J., Kruger, K., 2017 Psoriatic arthritis : Overview of drug therapy options and administration characteristics. Hautarzt No. 68(2): 153-169. http://doi.org/10.1007/s00105-016-3925-9

Bender, C., Christen, S., Scholich, K., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U., 2017 Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes. Diabetes (2017) No. 66(1): 113-126. http://doi.org/10.2337/db16-0547

Borsari, C., Santarem, N., Torrado, J., Olías, A.I., Corral, M.J., Baptista, C., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Witt, G., Gribbon, P., Reinshagen, J., Linciano, P., Tait, A., Costantino, L., Freitas-Junior, L.H., Moraes, C.B., Bruno dos Santos, P., Alcântara, L.M., Franco, C.H., Bertolacini, C.D., Fontana, V., Tejera Nevado, P., Clos, J., Alunda, J.M., Cordeiro-da-Silva, A., Ferrari, S., Costi, M.P., 2017. Methoxylated 2’-hydroxychalcones as antiparasitic hit compounds. European Journal of Medicinal Chemistry 126, 1129–1135. http://doi.org/10.1016/j.ejmech.2016.12.017

Dehne, N., Mora, J., Namgaladze, D., Weigert, A., Brüne, B., 2017. Cancer cell and macrophage cross-talk in the tumor microenvironment. Current Opinion in Pharmacology 35, 12–19. http://doi.org/10.1016/j.coph.2017.04.007

Di Pisa, F., Landi, G., Dello Iacono, L., Pozzi, C., Borsari, C., Ferrari, S., Santucci, M., Santarem, N., Cordeiro-Da-Silva, A., Moraes, C.B., Alcantara, L.M., Fontana, V., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Behrens, B., Pöhner, I., Wade, R.C., Costi, M.P., Mangani, S., 2017. Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity. Molecules 22. http://doi.org/10.3390/molecules22030426

Dimova, V., Oertel, B.G., Lötsch, J., 2017. Using a standardized clinical quantitative sensory testing battery to judge the clinical relevance of sensory differences between adjacent body areas. Clinical Journal of Pain 33, 37–43. http://doi.org/10.1097/AJP.0000000000000372

Florian, P., Wonerow, P., Harder, S., Kuczka, K., Dubar, M., Graff, J., 2017. Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber. Eur J Clin Pharmacol 73, 949–956. http://doi.org/10.1007/s00228-017-2264-9

Fuhrmann, D.C., Brüne, B., 2017. Mitochondrial composition and function under the control of hypoxia. Redox Biology 12, 208–215. http://doi.org/10.1016/j.redox.2017.02.012

Grösch, S., Niederberger, E., Geisslinger, G., 2017. Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain. Expert Opinion on Investigational Drugs 26, 51–61. http://doi.org/10.1080/13543784.2017.1260544

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R., 2017. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Environ Sci Pollut Res 1–14. http://doi.org/10.1007/s11356-017-8977-6

Hohmann, S.W., Angioni, C., Tunaru, S., Lee, S., Woolf, C.J., Offermanns, S., Geisslinger, G., Scholich, K., Sisignano, M., 2017. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Scientific Reports 7. http://doi.org/10.1038/s41598-017-00591-0

Janas, C., Mast, M.-P., Kirsamer, L., Angioni, C., Gao, F., Mäntele, W., Dressman, J., Wacker, M.G., 2017. The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers. European Journal of Pharmaceutics and Biopharmaceutics 115, 73–83. http://doi.org/10.1016/j.ejpb.2017.02.006

Jeske, J., Windshügel, B., Thasler, W.E., Schwab, M., Burk, O., 2017. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Archives of Toxicology 91, 2375–2390. http://doi.org/10.1007/s00204-017-1948-3

Jung, M., Mertens, C., Bauer, R., Rehwald, C., Brüne, B., 2017a. Lipocalin-2 and iron trafficking in the tumor microenvironment. Pharmacological Research 120, 146–156. http://doi.org/10.1016/j.phrs.2017.03.018

Jung, M., Weigert, A., Mertens, C., Rehwald, C., Brüne, B., 2017b. Iron handling in tumor-associated macrophages-Is there a new role for lipocalin-2? Frontiers in Immunology 8. http://doi.org/10.3389/fimmu.2017.01171

Koch, A., Grammatikos, G., Trautmann, S., Schreiber, Y., Thomas, D., Bruns, F., Pfeilschifter, J., Badenhoop, K., Penna-Martinez, M., 2017. Vitamin D supplementation enhances C18(Dihydro)ceramide levels in type 2 diabetes patients. International Journal of Molecular Sciences 18. http://doi.org/10.3390/ijms18071532

Kringel, D., Sisignano, M., Zinn, S., Lötsch, J., 2017. Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeqTM panel. PLoS ONE 12. http://doi.org/10.1371/journal.pone.0180116

Niederberger, E., Resch, E., Parnham, M.J., Geisslinger, G., 2017. Drugging the pain epigenome. Nature Reviews Neurology 13, 434–447. http://doi.org/10.1038/nrneurol.2017.68

Oertel, S., Scholich, K., Weigert, A., Thomas, D., Schmetzer, J., Trautmann, S., Wegner, M.-S., Radeke, H.H., Filmann, N., Brüne, B., Geisslinger, G., Tegeder, I., Grösch, S., 2017. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell. Mol. Life Sci. 74, 3039–3055. http://doi.org/10.1007/s00018-017-2518-9

Parnham, M.J., 2017. Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications. Inflammation Research 66. http://doi.org/10.1007/s00011-016-0988-0

Pierre, S., Linke, B., Suo, J., Tarighi, N., Del Turco, D., Thomas, D., Ferreiros, N., Stegner, D., Frölich, S., Sisignano, M., Meyer Dos Santos, S., deBruin, N., Nüsing, R.M., Deller, T., Nieswandt, B., Geisslinger, G., Scholich, K., 2017. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. Journal of Investigative Dermatology 137, 686–695. http://doi.org/10.1016/j.jid.2016.09.036

Rahlff, J., Peters, J., Moyano, M., Pless, O., Claussen, C., Peck, M.A., 2017. Short-term molecular and physiological responses to heat stress in neritic copepods Acartia tonsa and Eurytemora affinis. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology 203, 348–358. http://doi.org/10.1016/j.cbpa.2016.11.001

Schneider, C., Oellerich, T., Baldauf, H.-M., Schwarz, S.-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W.E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M.-L., Yakunin, A.F., Geisslinger, G., Ströbel, P., Ferreirós, N., Serve, H., Keppler, O.T., Cinatl, J., 2017. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nature Medicine 23, 250–255. http://doi.org/10.1038/nm.4255

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M., 2017. Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics 24, 29–40. http://doi.org/10.1016/j.cbd.2017.07.004

Stolz, A., Putyrski, M., Kutle, I., Huber, J., Wang, C., Major, V., Sidhu, S.S., Youle, R.J., Rogov, V.V., Dötsch, V., Ernst, A., Dikic, I., 2017. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO Journal 36, 549–564. http://doi.org/10.15252/embj.201695063

Ueck, C., Volksdorf, T., Houdek, P., Vidal-Y-Sy, S., Sehner, S., Ellinger, B., Lobmann, R., Larena-Avellaneda, A., Reinshagen, K., Ridderbusch, I., Kohrmeyer, K., Moll, I., Daniels, R., Werner, P., Merfort, I., Brandner, J.M., 2017. Comparison of in-vitro and ex-vivo wound healing assays for the investigation of diabetic wound healing and demonstration of a beneficial effect of a triterpene extract. PLoS ONE 12. http://doi.org/10.1371/journal.pone.0169028

von Delius, M., Le, C.M., Ellinger, B., Kuzikov, M., Gul, S., Dong, V.M., 2017. Synthesis and Biological Activity of Octaketides from the Cytosporone Family. Israel Journal of Chemistry 57, 975–981. http://doi.org/10.1002/ijch.201700023

Wobst, I., Ebert, L., Birod, K., Wegner, M.-S., Hoffmann, M., Thomas, D., Angioni, C., Parnham, M.J., Steinhilber, D., Tegeder, I., Geisslinger, G., Grösch, S., 2017. R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4. International Journal of Molecular Sciences 18. http://doi.org/10.3390/ijms18010068

Zinn, S., Sisignano, M., Kern, K., Pierre, S., Tunaru, S., Jordan, H., Suo, J., Treutlein, E.-M., Angioni, C., Ferreiros, N., Leffler, A., Debruin, N., Offermanns, S., Geisslinger, G., Scholich, K., 2017. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. Journal of Biological Chemistry 292, 6123–6134. http://doi.org/10.1074/jbc.M116.769125

A - C

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, Bernal- Delgado E. et al.: Making sense of big data in health research: Towards an EU action plan. Genome Medicine (2016) No.8(1): 71 (http://doi.org/10.1186/s13073-016-0323-y)

Aygören-Pürsün, E., Magerl, M., Graff, J., Martinez-Saguer, I., Kreuz, W., Longhurst, H., Nasr, I., Bas, M., Straßen, U., Fang, L., Cornpropst, M., Dobo, S., Collis, P., Sheridan, W.P., Maurer, M.: Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. The Journal of Allergy Clinical Immunology (2016) pii: S0091-6749(16)30270-6 (http://doi.org/10.1016/j.jaci.2016.03.043)

Barthelmes, J., Tafferner, N., Kurz, J., de Bruin, N., Parnham, M.J., Geisslinger, G., Schiffmann, S.: Induction of experimental autoimmune encephalomyelitis in mice and evaluation of the disease-dependent distribution of immune cells in various tissues. Journal of visualized experiments: JoVE. Online resource 2016 (2016) No. 111 (http://doi.org/10.3791/53933)

Behrens, F., Koehm, M., Thaci, D., Gnann, H., Greger, G., Wittig, B.M., Burkhardt, H.: Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology 55 (2016) No. 10: 1791- 1795 (http://doi.org/10.1093/rheumatology/kew229)

Behrens, F., Koehm, M., Arndt, U., Wittig, B.M., Greger, G., Thaci, D., Scharbatke, E., Tony, H.-P., Burkhardt, H.: Does concomitant methotrexate with Progadalimumab influence treatment outcomes in patients with psoriatic arthritis? Data from a large observational study. The Journal of Rheumatology 43 (2016) No. 3: 632-639 (http://doi.org/10.3899/jrheum.141596)

Behrens, F., Thaci, D., Wollenhaupt, J., Krüger, K.: Psoriasisarthritis: Übersicht medikamentöser Therapieoptionen und Anwendungsbesonderheiten. Zeitschrift für Rheumatologie 75 (2016) No. 5, 471-488 (http://doi.org/10.1007/s00393-016-0110-6)

Beyer, S., Xie, L., Schmidt, M., de Bruin, N., Ashtikar, M., Rüschenbaum, S., Lange, C.M., Vogel, V.; Mäntele, W., Parnham, M.J., Wacker, M.G.: Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. Journal of controlled release 235 (2016), 352-364 (http://doi.org/10.1016/j.jconrel.2016.06.013)

Blöcher, R., Lamers, C., Wittmann, S.K., Merk, D., Hartmann, M., Weizel, L., Diehl, O., Brüggerhoff, A., Boss, M., Kaiser, A., Schader, T., Gobel, T., Grundmann, M., Angioni, C., Heering, J., Geisslinger, G., Wurglics, M., Kostenis, E., Brüne, B., Steinhilber, D., Schubert-Zsilavecz, M., Kahnt, A.S., Proschak, E.: N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators. Journal of medicinal chemistry 59 (2016) No. 1: 61-81 (http://doi.org/10.1021/acs.jmedchem.5b01239)

Bodewein, L., Schmelter, F., Di Fiore, S., Hollert, H., Fischer, R., Fenske, M.: Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicology and Applied Pharmacology 305 (2016) 83-92 (http://doi.org/10.1016/j.taap.2016.06.008)

Borsari, C., Luciani, R., Pozzi, C., Poehner, I., Henrich, S., Trande, M., Cordeiro-da- Silva, A., Santarem, N., Baptista, C., Tait, A., Di Pisa, F., Dello Iacono, L., Landi, G., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Gribbon, P., Kohler, M., Keminer, O., Behrens, B., Costantino, L., Tejera Nevado, P., Bifeld, E., Eick, J., Clos, J., Torrado, J., Jiménez- Antón, M.D., Corral, M.J., Alunda, J.M., Pellati, F., Wade, R.C., Ferrari, S., Mangani, S., Costi, M.P.: Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs. Journal of Medicinal Chemistry (2016) No. 59(16): 7598-7616 (http://doi.org/10.1021/acs.jmedchem.6b00698)

Boß, M., Newbatt, Y., Gupta, S., Collins, I., Brüne, B., Namgaladze, D.: AMPK-independent inhibition of human macrophage ER stress response by AICAR. Scientific Reports 6 (2016), Art. 32111, 10 (http://doi.org/10.1038/srep32111)

Brändl, B., Schuldt, B.M., Böhnke, L., Keminer, O., Vaas, L.A.I., Fischer, R., Müller, F.J., Pless, O.: Utilizing regulatory networks for pluripotency assessment in stem cells. Current Stem Cell Reports (2016), No. 2(3): 228-235. Review. (http://dx.doi.org/10.1007%2Fs40778-016-0054-4)

Brenke, J.K., Salmina, E.S., Ringelstetter, L., Dornauer, S., Kuzikov, M., Rothenaigner, I., Schorpp, K., Giehler, F., Gopalakrishnan, J., Kieser, A., Gul, S., Tetko, I.V., Hadian, K.: Identification of small-molecule frequent hitters of glutathione s-transferase- glutathione interaction. Journal of Biomolecular Screening 21 (2016) No.6: 596-607 (http://doi.org/10.1177/1087057116639992)

Brenneis, M., Aghajaanpour, R., Knape, T., Sha, L.K., Neb, H., Meybohm, P., Zacharowski, K., Hauser, I.A., Buttner, S., Parnham, M.J., Brune, B., Von Knethen, A.: Pparg Expression in T Cells as a Prognostic Marker of Sepsis. Shock 45 (2016), No. 6: 591-597 (http://doi.org/10.1097/SHK.0000000000000568)

Briken, S., Rosenkranz, S.C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pless, O., Schulz, K.H., Gold, S.M.: Effects of exercise on irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of Neuroimmunology (2016) No. 299: 53-58 (http://doi.org/10.1016/j.jneuroim.2016.08.007)

Brüne, B., Courtial, N., Dehne, N., Syed, S.N., Weigert, A.: Macrophage NOS2 in tumor leukocytes. Antioxidants & Redox Signaling. [Epub ahead of print] (http://doi.org/10.1089/ars.2016.6811)

Bruin, N.M.W.J. de, Schmitz, K., Schiffmann, S., Tafferner, N., Schmidt, M., Jordan, H., Häußler, A., Tegeder, I., Geisslinger, G., Parnham, M.J.: Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behavioural Brain Research 300 (2016) 160-174 (http://doi.org/10.1016/j.bbr.2015.12.006)

Bruin de, N.M.W.J., van Loevezijn, A., Wicke, K.M., de Haan, M., Venhorst, J., Lange, J.H.M., de Groote, L., van der Neut, M.A.W., Prickaerts, J., Andriambeloson, E., Foley, A.G., van Drimmelen, M., van der Wetering, M., Kruse, C.G.: The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment. Neurobiology of Learning and Memory (2016) No. 133: 100–117 (http://doi.org/10.1016/j.nlm.2016.06.020) )

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., Fitzgerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A.; Barton, A.: Replication of a distinct psoriatic arthritis risk variant at the IL23R locus. Annals of the rheumatic diseases 75 (2016) No. 7: 1417-1418 (http://doi.org/10.1136/annrheumdis-2016-209290)

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., FitzGerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A., Barton, A.: Validation of a distinct psoriatic arthritis risk variant at IL23R. Rheumatology 55 (2016), Supplement 1, Abstract 219, i150-i151

Burkhardt, H., Weisenseel, P., Radtke, M.A., Krüger, K.: Hautmalignome und immunmodulierende Antirheumatikatherapie. Zeitschrift für Rheumatologie 75 (2016), No. 1: 32-40 (http://doi.org/10.1007/s00393-015-0037-3)

Capelo, R., Lehmann, C., Ahmad, K., Snodgrass, R., Diehl, O., Ringleb, J., Flamand, N., Weigert, A., Stark, H., Steinhilber, D., Kahnt, A.S.: Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochemical pharmacology 103 (2016) 74-84 (http://doi.org/10.1016/j.bcp.2016.01.007)

Combe, B., Behrens, F., McHugh, N., Brock, F., Kerkmann, U., Kola, B., Gallo, G.: Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis: Results from 2 clinical trials. The Journal of Rheumatology 43 (2016) No. 6: 1063-1067 (http://doi.org/10.3899/jrheum.151290)

 

D - F

de Araujo, L.S., Vaas, L.A., Ribeiro-Alves, M., Geffers, R., Mello, F.C., de Almeida, A.S., Moreira, A.D., Kritski, A.L., Lapa, E Silva JR, Moraes, M.O., Pessler, F., Saad, M.H.: Transcriptomic biomarkers for tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA expression in peripheral blood. Frontiers in Microbiology (2016) No. 7: 1586 (http://doi.org/10.3389/fmicb.2016.01586)

Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Finl, A.F., Roberts, E., Brüne, B., Weigert, A.: S1PR4 signaling attenuates ILT7 internalization to limit IFN-a production by human plasmacytoid dendritic cells. The Journal of Immunology (2016) No. 196 (4): 1579-1590 (http://doi.org/10.4049/jimmunol.1403168)

Drebes, J., Künz, M., Windshügel, B., Kikhney, A.G., Müller, I.B., Eberle, R.J., Oberthür, D., Cang, H., Svergun, D.I., Perbandt, M., Betzel, C., Wrenger, C.: Structure of ThiM from vitamin B1 biosynthetic pathway of Staphylococcus aureus – insights into a novel pro-drug approach addressing MRSA infections. Scientific Reports (2016) No. 6: 22871 (http://doi.org/10.1038/srep22871)

Ellinger, B., Gribbon P.: Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery (2016) No. 133(4): 333-336 (http://doi.org/10.1517/17460441.2016.1152257)

Fenske, M., Gul, S.: Zebrafish early-life stages as neurological screening and detection tools. Drug Target Review, Volume 3, Autumn 2016, 41-43 (URL: https://www.drugtargetreview.com/article/14205/hit-to-lead-in-depth-focus-2016/)

Frenz, T., Grabski, E., Buschjäger, D., Vaas, L.A., Burgdorf, N., Schmidt, R.E., Witte, T., Kalinke, U.: CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. The Journal of Allergy Clinical Immunology (2016) No. 138(2): 586-589.e10 (http://doi.org/10.1016/j.jaci.2016.04.013)

 

G - L

Graff, J., Scheuermann, E.H., Brandhorst, G., Oellerich, M., Gossmann, J.: Pharmacokinetic analysis of mycophenolate mofetil and enteric-coated mycophenolate sodium in calcineurin inhibitor-free renal transplant recipients. Ther Drug Monit. (2016) No. 38(3): 388-392 (http://doi.org/10.1097/FTD.0000000000000281)

Grimm, M., Tischner, D., Troidl, K., Albarran Juarez, J., Sivaraj, K. K., Ferreiros Bouzas, N., Geisslinger, G., Binder, C. J., Wettschureck, N.: S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population. Arteriosclerosis, Thrombosis, and Vascular Biology 36 (2016) No. 1: 37-48 (http://doi.org/10.1161/ATVBAHA.115.306066)

Hanke, T., Merk, D., Steinhilber, D., Geisslinger, G., Schubert-Zsilavecz, M.: Small molecules with anti-inflammatory properties in clinical development. Pharmacology & therapeutics 157 (2016) 163-87 (http://doi.org/10.1016/j.pharmthera.2015.11.011)

Hauser, A.S., Windshügel, B.: LEADS-PEP: A benchmark data set for assessment of peptide docking performance. Journal of Chemical Information and Modeling 2016 Jan 25; No. 56(1): 188- 200 (http://doi.org/10.1021/acs.jcim.5b00234)

Henke, N., Ferreiros, N., Geisslinger, G., Ding, M. G., Essler, S., Fuhrmann, D. C., Geis, T., Namgaladze, D., Dehne, N., Brune, B.: Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Oncotarget 7 (2016) No. 18: 25915-29 (http://doi.org/10.18632/oncotarget.8297)

Hunzelmann, N., Riemekasten, G., Becker, M.O., Moinzadeh, P., Kreuter, A., Melchers, I., Mueller-Ladner, U., Meier, F., Worm, M., Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sárdy, M., Burkhardt, H., Koehm, M., Kuhr, K., Krieg, T., Sunderkötter, C.: The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase- 1 antibodies. The British Journal of Dermatology 174 (2016) No. 6: 1384-1387 (http://doi.org/10.1111/bjd.14367)

Josipovic, I., Fork, C., Preussner, J., Prior, K. K., Iloska, D., Vasconez, A. E., Labocha, S., Angioni, C., Thomas, D., Ferreiros, N., Looso, M., Pullamsetti, S. S., Geisslinger, G. Steinhilber, D., Brandes, R. P., Leisegang, M. S.: PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Acta Physiologica 2018 (2016) No. 1: 13-27 (http://doi.org/10.1111/apha.12700)

Kemmerer, M., Wittig, I., Richter, F., Brüne, B., Namgaladze, D.: AMPK activates LXRa and ABCA1 expression in human macrophages. The International Journal of Biochemistry & Cell Biology (2016) No. 78: 1-9 (http://doi.org/10.1016/j.biocel.2016.06.014)

King-Himmelreich, T.S., Schramm, S., Wolters, M.C., Schmetzer, J., Moser, C.V., Knothe, C., Resch, E., Peil, J., Geisslinger, G., Niederberger, E.: The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochemical and Biophysical Research Communications 474 (2016) No. 2: 284-290 (http://doi.org/10.1016/j.bbrc.2016.04.078)

Klemmt, P.A., Resch, E., Smyrek, I., Engels, K., Stelzer, E.H., Starzinski-Powitz, A.: Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile. Biology Open 15 (2016) No. 5(11), 1607-1619 (http://doi.org/10.1242/bio.019463)

Klingler, F.M., Wolf, M., Wittmann, S., Gribbon, P., Proschak, E.: Bacterial expression and HTS assessment of soluble epoxide hydrolase phosphatase. Journal of Biomolecular Screening (2016) No. 7: 689-94 (http://doi.org/10.1177/1087057116637609)

Knothe, C., Shiratori, H., Resch, E., Ultsch, A., Geisslinger, G., Doehring, A., Lotsch, J.: Disagreement between two common biomarkers of global DNA methylation. Clinical Epigenetics 8 (2016) 60 (http://doi.org/10.1186/s13148-016-0227-0)

Knothe, C., Oertel, B. G., Ultsch, A., Kettner, M., Schmidt, P. H., Wunder, C., Toennes, S. W., Geisslinger, G., Lotsch, J.: Pharmacoepigenetics of the role of DNA methylation in mu-opioid receptor expression in different human brain regions. Epigenomics 8 (2016) No. 12: 1583- 1599 (http://doi.org/10.2217/epi-2016-0072)

Kringel, D., Ultsch, A., Zimmermann, M. ,Jansen, J.P., Ilias, W., Freynhagen, R., Griessinger, N., Kopf, A., Stein, C., Doehring, A., Resch, E., Lotsch, J.: Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses. Pharmacogenomics Journal (2016) 1-8 (http://doi.org/10.1038/tpj.2016.28)

Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., Schachner, M.: Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions. Journal of Neurochemistry (2016) No. 136(1): 48-62 (http://doi.org/10.1111/jnc.13383)

Loevezijn van, A., Venhorst, J., Iwema Bakker, W.I., Lange, J.H.M., de Looff, W., Henzen, R., de Vries, J., van de Woestijne, R.P., den Hartog, A.P., Verhoog, S., van der Neut, M.A.W., de Bruin, N.M.W.J., Kruse, C.G.: Optimization of N’-(arylsulfonyl) pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket. Bioorganic & Medicinal Chemistry Letters (2016), No. 26: 1605–1611 (http://doi.org/ 10.1016/j.bmcl.2016.02.001)

Lötsch, J., Ultsch, A.: A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes. Integrative Biology 8 (2016) No. 1: 91-103 (http://doi.org/10.1039/c5ib00203f)

Lötsch, J., Ultsch, A., Hummel, T.: How many and which odor identification items are needed to establish normal olfactory function? Chemical Senses 41 (2016) No. 4: 339-344 (http://doi.org/10.1093/chemse/bjw006)

Lötsch, J., Ultsch, A.: A machine-learned computational functional genomics-based approach to drug classification. European Journal of Clinical Pharmacology 72 (2016), No. 12: 1449-1461 (http://doi.org/10.1007/s00228-016-2134-x)

Lötsch, J., Ultsch, A.: Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy. CPT. Pharmacometrics & Systems Pharmacology 5 (2016), No. 4: 192-200 (http://doi.org/10.1002/psp4.12072)

Lötsch, J., Dimova, V., Ultsch, A., Lieb, I., Zimmermann, M., Geisslinger, G., Oertel, B.G.: A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects. European Journal of Pain: EJP 20 (2016) No. 5: 777-789 (http://doi.org/10.1002/ejp.803)

Lötsch, J., Hähner, A., Gossrau, G., Hummel, C., Walter, C., Ultsch, A., Hummel, T.: Smell of paIntersection of nociception and olfaction. Pain 157 (2016) Nr. 10: 2152-2157 (http://doi.org/10.1097/j. pain.0000000000000599)

 

M - O

Maculins, T., Fiskin, E., Bhogaraju, S., Dikic, I.: Bacteria-host relationship: Ubiquitin ligases as weapons of invasion. Cell Research 26 (2016) No. 4: 499-510 (http://doi.org/10.1038/cr.2016.30)

Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J.W.M., Hay, R.T., Alwan, H.: A generic platform for cellular screening against ubiquitin ligases. Scientific Reports 6 (2016), Art. 18940, 10 (http://doi.org/10.1038/srep18940)

Meirer, K., Glatzel, D., Kretschmer, S., Wittmann, S. K., Hartmann, M., Blocher, R., Angioni, C., Geisslinger, G., Steinhilber, D., Hofmann, B., Furst, R., Proschak, E.: Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase. Molecules 22 (2016) No. 1 (http://doi.org/10.3390/molecules22010045)

Moll, J., Meyer dos Santos, S., Hils, B., Dornuf, F., Rodrigues Meyer dos Santos, I., Singer, O.C., Ferreiros, N., Labocha, S., Blücher, A., Harder, S., Krozer, V.: Micro-optical prototyping of a surface acoustic wave-based point-of-care coagulation assay and first application in anticoagulated patients. International Journal of Clinical Pharmacology and Therapeutics 54 (2016) No. 3: 177-184 (http://doi.org/10.5414/CP202492)

Mora, J., Schlemmer, A., Wittig, I., Richter, F., Putyrski, M., Frank, A.-C., Han, Y., Jung, M., Ernst, A., Weigert, A., Brüne, B.: Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol 8 (2016), 426–438. (http://doi.org/10.1093/jmcb/mjw006)

Möser, C.V., Meissner, M., Laarmann, K., Olbrich, K., King-Himmelreich, T.S., Wolters, M.C., Geisslinger, G., Niederberger, E.: The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. Biochemical Pharmacology 103 (2016), 64-73 (http://doi.org/10.1016/j.bcp.2015.12.016)

Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Baumann, L., Schäfers, C., Teigeler, M., Fenske, M.: Corrigendum to „Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test“. [Aquat. Toxicol. 176 (2016) 116-127] Aquatic Toxicology 177 (2016) 536 (http://doi.org/10.1016/j.aquatox.2016.05.010)

Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Baumann, L., Schäfers, C., Teigeler, M., Fenske, M.: Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquatic Toxicology 176 (2016) 116-127 (http://doi.org/10.1016/j.aquatox.2016.04.018)

Ören, B., Urosevic, J., Mertens, C., Mora, J., Guiu, M., Gomis, R.R., Weigert, A., Schmid, T., Grein, S., Brüne, B., Jung, M.: Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis. Journal of Pathology 239 (2016) No. 3: 274-285 (http://doi.org/10.1002/path.4724)

 

P - U

Parnham, M.J. (Ed.): Compendium of Inflammatory Diseases. Springer, Basel (2016). ISBN: 978-3- 0348-0620-6 (DOI 10.1007/978-3-7643-8550-7; http://doi.org/10.1007/978-3-0348-0620-6)

Parnham, M.J. (Ed.): Compendium of Inflammatory Diseases. Springer, Basel (2016). ISBN: 978-3- 0348-0620-6 (DOI 10.1007/978-3-7643-8550-7; http://doi.org/10.1007/978-3-0348-0620-6)

Pierre, S., Linke, B., Jing, S., Tarighi, N., Del Turco, D., Thomas, D., Ferreiros, N., Stegner, D., Frölich, S., Sisignano, M., Meyer Dos Santos, S., de Bruin, N., Nüsing, R.M., Deller, T., Nieswandt, B., Geisslinger, G., Scholich, K.: GPVI and thromboxane receptor on platelets promote proinflammatory macrophage phenotypes during cutaneous inflammation. Journal of Investigative Dermatology (in press) (http://doi.org/10.1016/j.jid.2016.09.036)

Roos, J., Grösch, S., Werz, O., Schröder, P., Ziegler, S., Fulda, S., Paulus, P., Urbschat, A., Kühn, B., Maucher, I., Fettel, J., Vorup-Jensen, T., Piesche, M., Matrone, C., Steinhilber, D., Parnham, M.J., Maier, T.J.: Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: a basis for novel drugs targeting cancer cells? Pharmacology and Therapeutics 157 (2016) 43-64 (http://doi.org/10.1016/j.pharmthera.2015.11.00)

Samir, M., Vaas, L.A., Pessler, F.: MicroRNAs in the host response to viral infections of veterinary importance. Frontiers in Veterinary Science (2016) No. 3: 86 (http://doi.org/10.3389/fvets.2016.00086)

Scharbatke, E.C., Behrens, F., Schmalzing, M., Koehm, M., Greger, G., Gnann, H., Burkhardt, H., Tony, H.P.: Association of improvement in pain with therapeutic response as determined by individual improvement criteria in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 68 (2016) 68: 1607-1615 (http://doi.org/10.1002/acr.22884)

Schmid, T., Blees, J.S., Bajer, M.M., Wild, J., Pescatori, L., Cuzzucoli Crucitti, G., Scipione, L., Costi, R., Henrich, C.J., Brüne, B., Colburn, N.H., Di Santo, R.: Diaryl disulfides as novel stabilizers of tumor suppressor Pdcd4. PLOS ONE 11 (2013), No. 3: e0151643 (http://doi.org/10.1371/journal.pone.0151643)

Schneider, C., Oellerich, T., Baldauf, H. M., Schwarz, S. M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W. E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M. L., Yakunin, A. F., Geisslinger, G., Strobel, P., Ferreiros, N., Serve, H., Keppler, O. T., Cinatl, J., Jr.: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nature Medicine 23 (2016) No. 2: 250- 55 (http://doi.org/10.1038/nm.4255)

Schröder, M., Kolodzik, A., Windshügel, B., Krepstakies, M., Priyadarshini, P., Hartjen, P., van Lunzen, J., Rarey, M., Hauber, J., Meier, C.: Linker-region modified derivatives of the deoxyhypusine synthase inhibitor CNI-1493 suppress HIV-1 replication. Archiv der Pharmazie (Weinheim) (2016) No. 349(2): 91-103. (http://doi.org/10.1002/ardp.201500323)

Shiratori, H., Feinweber, C., Knothe, C., Lötsch, J., Geisslinger, G., Parnham, M.J., Resch, E.: High-throughput analysis of global DNA methylation using methyl sensitive digestion. PLOS ONE. Online journal 11(10): e0163184 (2016)  (http://doi.org/10.1371/journal.pone.0163184)

Sisignano, M. , Angioni, C. , Park, C.- K., Meyer Dos Santos, S., Jordan, H., Kuzikov, M., Liu, D., Zinn, S., Hohman, S.W., Schreiber, Y., Zimmer, B., Schmidt, M., Lu, R., Suo, J., Zhang, D.-D., Schäfer, S.M.G., Hofmann, M., Yekkirala, A.S., de Bruin, N., Parnham, M.J., Woolf, C.J., Ji, R.-R., Scholich, K., Geisslinger, G.: Targeting CYP2J to reduce paclitaxelinduced peripheral neuropathic pain. Proceedings of the National Academy of Sciences (2016) No. 113: 12544–12549 (http://doi.org/10.1073/pnas.1613246113)

Sisignano, M., Parnham, M.J., Geisslinger, G.: Drug repurposing for the development of novel analgesics. Trends in Pharmacological Sciences 37 (2016)172-83 (http://dx.doi.org/10.1016%2Fj.tips.2015.11.006)

Smolen, J.S., Breedveld, F.C., Burmester, G.R., Bykerk, V.,M Dougados, M., Emery, P., Kvien, T.K., Navarro-Compán, M.V., Oliver, S., Schoels, M., Scholte-Voshaar, M., Stamm, T., Stoffer, M., Takeuchi, T., Aletaha, D., Andreu, J.L., Aringer, M., Bergman, M., Betteridge, N., Bijlsma, H., Burkhardt, H., Cardiel, M., Combe, B., Durez, P., Fonseca, J.E., Gibofsky, A., Gomez-Reino, J.J., Graninger, W., Hannonen, P., Haraoui, B., Kouloumas, M., Landewe, R., Martin-Mola, E., Nash, P., Ostergaard, M., Östör, A., Richards, P., Sokka-Isler, T., Thorne, C., Tzioufas, A.G., van Vollenhoven, R., de Wit, M., van der Heijde, D.: Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis 75 (2016) 3-15 (http://doi.org/10.1136/annrheumdis-2015-207524)

Tafferner, N., Barthelmes, J., Eberle, M., Ulshöfer, T., Henke, M., deBruin, N., Mayer, C., Foerch, C., Geisslinger, G., Parnham, M.J., Schiffmann, S.: Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. European Journal of Immunology (2016) No. 46(3): 570-581 (http://doi.org/10.1002/eji.201545782)

Thom, V., Schmid, S., Gelderblom, M., Hackbusch, R., Kolster, M., Schuster, S., Thomalla, G., Keminer, O., Pleß, O., Bernreuther, C., Glatzel, M., Wegscheider, K., Gerloff, C., Magnus, T., Tolosa, E.: IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis. Neurology: Neuroimmunology & Neuroin lammation (2016) No. 3(2): e214 (http://doi.org/10.1212/NXI.0000000000000214)

Ufer, F., Vargas, P., Engler, J.B., Tintelnot, J., Schattling, B., Winkler, H., Bauer, S., Kursawe, N., Willing, A., Keminer, O., Ohana, O., Salinas-Riester, G., Pless, O., Kuhl, D., Friese, M.A.: Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation. Science Immunology (2016): No. 1(3): pp. eaaf8665 (http://doi.org/10.1126/sciimmunol.aaf8665)

 

V - Z

Vaas, L.A.I., Witt, G., Windshügel, B., Bosin, A., Serra, G., Bruengger, A., Winterhalter, M., Gribbon, P., Levy-Petelinkar, C.J., Kohler, M.: Electronic laboratory notebooks in a public-private-partnership. PeerJ Computer Science (2016) No. 2: e83 (http://doi.org/10.7717/peerj-cs.83)

Wacker, M.G., Proykova, A., Santos, G.M.L.: Dealing with nanosafety around the globe – regulation vs. innovation. International Journal of Pharmaceutics 509 (2016) No.1-2: 95-106 (http://doi.org/10.1016/j.ijpharm.2016.05.015)

Walter, C., Knothe, C., Lötsch, J.: Abuse-deterrent opioid formulations: pharmacokinetic and pharmacodynamic considerations. Clinical pharmacokinetics 55 (2016) No. 7, 751-767 (http://doi.org/10.1007/s40262-015-0362-3)

Walter, C., Oertel, B.G., Felden, L., Kell, C.A., Nöth, U., Vermehren, J., Kaiser, J., Deichmann, R., Lötsch, J.: Brain mapping-based Model of D(9)-tetrahydrocannabinol effects on connectivity in the pain matrix. Neuropsychopharmacology. 2016 May;41(6):1659-69 (http://doi.org/10.1038/npp.2015.336)

Wegner, M. S., Schiffmann, S., Parnham, M. J., Geisslinger, G., Grosch, S.: The enigma of ceramide synthase regulation in mammalian cells. Progress in Lipid Research 63 (2016) 93-119 (http://doi.org/10.1016/j.plipres.2016.03.006)

Winkel, A.F., Engel, C.K., Margerie, D., Kannt, A., Szillat, H., Glombik, H., Kallus, C., Ruf, S., Güssregen, S., Riedel, J., Herling, A.W., von Knethen, A., Weigert, A., Brüne, B., Schmoll, D.: Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. Journal of Biological Chemistry 290 (2015) No. 47: 28446-28455 (http://doi.org/10.1074/jbc.M115.678136)

Wobst, I., Ebert, L., Birod, K., Wegner, M. S., Hoffmann, M., Thomas, D., Angioni, C., Parnham, M. J., Steinhilber, D., Tegeder, I., Geisslinger, G., Grosch, S.: R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4. International Journal of Molecular Sciences 18 (2016) No. 1 (http://doi.org/10.3390/ijms18010068)

Zschiebsch, K., Fischer, C., Pickert, G., Haussler, A., Radeke, H., Grosch, S .; Ferreiros, N., Geisslinger, G., Werner, E. R., Tegeder, I.: Tetrahydrobiopterin attenuates DSSevoked colitis in mice by rebalancing redox and lipid signalling. Journal of Crohn‘s and Colitis 10 (2016) No. 8: 965-78 (http://doi.org/10.1093/ecco-jcc/jjw056)

Behrens, F., Tak, P.P., Østergaard, M., Stoilov, R., Wiland, P., Huizinga, T.W., Berenfus, V.Y., Vladeva, S., Rech, J., Rubbert-Roth, A., Korkosz, M., Rekalov, D., Zupanets, I.A., Ejbjerg, B.J., Geiseler, J., Fresenius, J., Korolkiewicz, R.P., Schottelius, A.J., Burkhardt, H., 2015. MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial. Ann. Rheum. Dis. 74, 1058–1064. http://doi.org/10.1136/annrheumdis-2013-204816

Beyer, S., Moosmann, A., Kahnt, A.S., Ulshöfer, T., Parnham, M.J., Ferreirós, N., Wagner, S., Wacker, M.G., 2015. Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox. Pharm. Res. 32, 3986–3998. http://doi.org/10.1007/s11095-015-1759-2

Brändl, B., Schneider, S.A., Loring, J.F., Hardy, J., Gribbon, P., Müller, F.-J., 2015. Stem cell reprogramming: basic implications and future perspective for movement disorders. Mov. Disord. 30, 301–312. http://doi.org/10.1002/mds.26113

Cheng, X., Dimou, E., Alborzinia, H., Wenke, F., Göhring, A., Reuter, S., Mah, N., Fuchs, H., Andrade-Navarro, M.A., Adjaye, J., Gul, S., Harms, C., Utikal, J., Klipp, E., Mrowka, R., Wölfl, S., 2015a. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J. Med. Chem. 58, 4976–4983. http://doi.org/10.1021/acs.jmedchem.5b00144

Cheng, X., Yoshida, H., Raoofi, D., Saleh, S., Alborzinia, H., Wenke, F., Göhring, A., Reuter, S., Mah, N., Fuchs, H., Andrade-Navarro, M.A., Adjaye, J., Gul, S., Utikal, J., Mrowka, R., Wölfl, S., 2015b. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J. Med. Chem. 58, 5742–5750. http://doi.org/10.1021/acs.jmedchem.5b00226

Jennewein, C., Sowa, R., Faber, A.C., Dildey, M., von Knethen, A., Meybohm, P., Scheller, B., Dröse, S., Zacharowski, K., 2015. Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation. Am. J. Respir. Cell Mol. Biol. 53, 656–663. http://doi.org/10.1165/rcmb.2014-0354OC

Lötsch, J., Knothe, C., Lippmann, C., Ultsch, A., Hummel, T., Walter, C., 2015. Olfactory drug effects approached from human-derived data. Drug Discov. Today 20, 1398–1406. http://doi.org/10.1016/j.drudis.2015.06.012

Lu, R., Bausch, A.E., Kallenborn-Gerhardt, W., Stoetzer, C., Debruin, N., Ruth, P., Geisslinger, G., Leffler, A., Lukowski, R., Schmidtko, A., 2015. Slack channels expressed in sensory neurons control neuropathic pain in mice. J. Neurosci. 35, 1125–1135. http://doi.org/10.1523/JNEUROSCI.2423-14.2015

Namgaladze, D., Snodgrass, R.G., Angioni, C., Grossmann, N., Dehne, N., Geisslinger, G., Brüne, B., 2015. AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages. J. Biol. Chem. 290, 24484–24494. http://doi.org/10.1074/jbc.M115.678243

Thaçi, D., Behrens, F., Greger, G., Burkhardt, H., Gnann, H., Schopf, R., Wittig, B.M., 2015. Association between skin and joint involvement in patients with psoriatic arthritis treated with adalimumab: analysis of data from a German non-interventional study. Dermatology (Basel) 230, 213–221. http://doi.org/10.1159/000371546

Winkel, A.F., Engel, C.K., Margerie, D., Kannt, A., Szillat, H., Glombik, H., Kallus, C., Ruf, S., Güssregen, S., Riedel, J., Herling, A.W., von Knethen, A., Weigert, A., Brüne, B., Schmoll, D., 2015. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J. Biol. Chem. 290, 28446–28455. http://doi.org/10.1074/jbc.M115.678136

Zeller, T., Haase, T., Müller, C., Riess, H., Lau, D., Zeller, S., Krause, J., Baumert, J., Pless, O., Dupuis, J., Wild, P.S., Eleftheriadis, M., Waldenberger, M., Zeilinger, S., Ziegler, A., Peters, A., Tiret, L., Proust, C., Marzi, C., Munzel, T., Strauch, K., Prokisch, H., Lackner, K.J., Herder, C., Thorand, B., Benjamin, E.J., Blankenberg, S., Koenig, W., Schnabel, R.B., 2015. Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels. Circ Cardiovasc Genet 8, 717–726. http://doi.org/10.1161/CIRCGENETICS.115.001079

Gul, S., Hadian, K., 2014. Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays. Expert Opin Drug Discov 9, 1393–1404. http://doi.org/10.1517/17460441.2014.954544

Haag, S., Schneider, N., Mason, D.E., Tuncel, J., Andersson, I.E., Peters, E.C., Burkhardt, H., Holmdahl, R., 2014. Identification of new citrulline-specific autoantibodies, which bind to human arthritic cartilage, by mass spectrometric analysis of citrullinated type II collagen. Arthritis & Rheumatology (Hoboken, N.J.) 66, 1440–1449. http://doi.org/10.1002/art.38383

Homann, J., Lehmann, C., Kahnt, A.S., Steinhilber, D., Parnham, M.J., Geisslinger, G., Ferreirós, N., 2014. Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators. J Chromatogr A 1360, 150–163. http://doi.org/10.1016/j.chroma.2014.07.068

Lorenz, J.E., Kallenborn-Gerhardt, W., Lu, R., Syhr, K.M.J., Eaton, P., Geisslinger, G., Schmidtko, A., 2014. Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury. Antioxid. Redox Signal. 21, 1504–1515. http://doi.org/10.1089/ars.2013.5585

Lötsch, J., Oertel, B.G., Ultsch, A., 2014. Human models of pain for the prediction of clinical analgesia. Pain 155, 2014–2021. http://doi.org/10.1016/j.pain.2014.07.003

Lu, R., Bausch, A.E., Kallenborn-Gerhardt, W., Stoetzer, C., Debruin, N., Ruth, P., Geisslinger, G., Leffler, A., Lukowski, R., Schmidtko, A., 2015. Slack channels expressed in sensory neurons control neuropathic pain in mice. J. Neurosci. 35, 1125–1135. http://doi.org/10.1523/JNEUROSCI.2423-14.2015

Mathäs, M., Nusshag, C., Nuβhag, C., Burk, O., Gödtel-Armbrust, U., Herlyn, H., Wojnowski, L., Windshügel, B., 2014. Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor. PLoS ONE 9, e96263. http://doi.org/10.1371/journal.pone.0096263

Oertel, B.G., Vermehren, J., Huynh, T.T., Doehring, A., Ferreiros, N., Zimmermann, M., Geisslinger, G., Lötsch, J., 2014. Cytochrome P450 epoxygenase dependence of opioid analgesia: fluconazole does not interfere with remifentanil-mediated analgesia in human subjects. Clin. Pharmacol. Ther. 96, 684–693. http://doi.org/10.1038/clpt.2014.169

Schmitz, K., de Bruin, N., Bishay, P., Männich, J., Häussler, A., Altmann, C., Ferreirós, N., Lötsch, J., Ultsch, A., Parnham, M.J., Geisslinger, G., Tegeder, I., 2014. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med 6, 1398–1422. http://doi.org/10.15252/emmm.201404168

Schuh, C.D., Brenneis, C., Zhang, D.D., Angioni, C., Schreiber, Y., Ferreiros-Bouzas, N., Pierre, S., Henke, M., Linke, B., Nüsing, R., Scholich, K., Geisslinger, G., 2014. Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors. Anesthesiology 120, 447–458. http://doi.org/10.1097/ALN.0b013e3182a76f74

Sisignano, M., Baron, R., Scholich, K., Geisslinger, G., 2014. Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nat Rev Neurol 10, 694–707. http://doi.org/10.1038/nrneurol.2014.211

Stürner, K.H., Borgmeyer, U., Schulze, C., Pless, O., Martin, R., 2014. A multiple sclerosis-associated variant of CBLB links genetic risk with type I IFN function. J. Immunol. 193, 4439–4447. http://doi.org/10.4049/jimmunol.1303077